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Doctor insights on: Fibrosis Stage 3

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I'm 22 months out liver transplant due to "cryptogenic cirrhosis" now have stage 3 fibrosis with bridging. No hepc. Lupus. Progression/prognosis?

I'm 22 months out liver transplant due to "cryptogenic cirrhosis" now have stage 3 fibrosis with bridging. No hepc. Lupus. Progression/prognosis?

Discuss with doc: Problems like these can only be correctly handled by your doctor in person. He/she needs to listen to you, perform an examination and possibly run labs or other tests. That's the only way he/she can find out what's going on and what to do about it. ...Read more

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Lab says normal liver ammonia is between 27-102.husbands is 108 and doctor put him on lactulose. Has stage 3 fibrosis. Why when ammonia not that high?

Lab says normal liver ammonia is between 27-102.husbands is 108 and doctor put him on lactulose. Has stage 3 fibrosis. Why when ammonia not that high?

Intersting question: Very interesting question. If you take 1/2 of healthy liver out surgically liver func will still be normal. Person with fibrosis and ammonia even though slightly elevated signifies significant loss of liver function. Please follow your physician's advice ...Read more

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Husband has liver fibrosis bridging cirrhosis but stopped drinking. Takes lactulose and stopped drinking three months ago. Will disesase get better?

Husband has liver fibrosis bridging cirrhosis but stopped drinking. Takes lactulose and stopped drinking three months ago. Will disesase get better?

Hoping so!: I'm going to assume that alcohol is the sole cause, and that he's been checked for hemochromatosis, Wilson's, and hepatitis B and C. If he does choose to stop drinking, having a loving and forgiving wife will be the most wonderful support he can have. Cirrhosis does regress some on achieving sobriety. Hopefully his mind is still basically okay. Wishing you both the best. ...Read more

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Husbands biopsy three months ago showed fibrosis bridging cirrhosis from alcohol. Abdominal ultrasound came back normal last week. Why normal ultrasound?

Husbands biopsy three months ago showed fibrosis bridging cirrhosis from alcohol. Abdominal ultrasound came back normal last week. Why normal ultrasound?

Nature of ultrasound: This is kind of subtle, and I'll try to explain as I'm a pathologist. Especially if your husband's disease is due to alcohol, all the little units of the liver are affected about the same, so ultrasound -- which lights up borders between areas of different consistency -- won't show a thing. This is actually good news. If I recall, he's sober now and I hope he recovers well. ...Read more

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What is vaginal fibrosis and how do you cure it?

What is vaginal fibrosis and how do you cure it?

Vaginal fibrosis: You can think of vaginal fibrosis as bad scar tissue in the vagina. It typically is the side effect of radiation therapy for gynecologic cancers. The vagina looses its elasticity and can shrink. ...Read more

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Hi doctors, can you tell me what is retropertineal fibrosis?

Hi doctors, can you tell me what is retropertineal fibrosis?

Retroperitoneal Fibr: Retroperitoneal fibrosis is a rare disease, often idiopathic, but drugs, infections malignancies, prior surgeries, radiation therapy, smoking, and asbestos exposure have been implicated.. It is characterized by the presence of inflammatory and fibrous retroperitoneal tissue that often encases the ureters & other abdominal organs. Symptoms include back or flank pain, and decreased kidney function ...Read more

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What are the causes of persistent left basal discoid fibrosis?

What are the causes of persistent left basal discoid fibrosis?

On the lung?: Gosh could be quite a lot for this. If it is stable over years, cancer is MOSTLY ruled out (sometimes cancer can develop in a scar). And lung diseases such as COPD, or other causes of lung hyperinflation cause the bottom to get squished. For that matter obesity can squish them from the other direction! ...Read more

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My fibrosure test came backbut for fibrosis interpretation it says see note and for necroinflammat interp it says see note, why and also says see note?

My fibrosure test came backbut for fibrosis interpretation it says see note and for necroinflammat interp it says see note, why and also says see note?

Talk with your doc: Over 95% of tests are interpretable and allow a diagnosis of fibrosis and liver activity. In less than 5% of cases, likely false positives or false negatives are highlighted. FibroTest has been validated for chronic hepatitis C, [1] chronic hepatitis B, [2] chronic hepatitis C or B with HIV co-infection, [9] alcoholic liver diseases (steatosis and steatohepatitis), [3] and non-alcoholichepatitis ...Read more

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What is cystic fibrosis?

What is cystic fibrosis?

Genetic disorder: It is a genetic disorder characterized by abnormal sodium channels, which affect a great deal of problems including the respiratory and digestive systems. It is most commonly diagnosed in infants failing to gain appropriate weight, and in children who have multiple chronic infections. ...Read more

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What is cystic fibrosis exactly?

What is cystic fibrosis exactly?

Inherited disease: Cystic fibrosis (CF) is an inherited disease that affects the cells lining the lungs, sinuses, intestines, spleen and liver. It prevents chloride ions from crossing the cell membranes properly. This can clog organ ducts. In the lungs, the extra mucus crushes the cilia and leads to more lung infections. Medications can help; in late-stage disease, lung transplantation may be life-saving. ...Read more

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What exactly is cystic fibrosis?

What exactly is cystic fibrosis?

Cystic fibrosis: CF is a genetic disease that from birth causes the body to produce a thick and sticky mucus. This mucus interferes with the ability to breath and digest food. It is life threatening, but with good management people can live into their 40s and beyond with it. ...Read more

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What is retroperitoneal fibrosis?

What is retroperitoneal fibrosis?

Chronic scarring: Idiopathic retroperitoneal fibrosis is a chronic non-specific inflammation of the retroperitoneum, which can entrap and obstruct important structures, notably the ureters. The average age of diagnosis is about 55 years and the male:female ratio was 3:1. Options for treatment include corticosteroids, other immunosuppressive and hormonal treatment (such as tamoxifen), as well as surgery. ...Read more

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Cystic fibrosis, is it sexlinked?

Cystic fibrosis, is it sexlinked?

Autosomal recessive.: Cystic fibrosis (CF) is not sex-linked, but autosomal recessive. That means both parents can be silent carriers--totally unaware--then each passes down this recessive (inactive) gene to their child. This child develops CF because both copies of the formerly inactive gene (1 from each parent) now have no genetic "brake" (normal dominant gene) to prevent the CF gene from expressing itself. ...Read more

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What is the severity of cystic fibrosis?

What is the severity of cystic fibrosis?

Variable: This depends on the individual patient. There are several hundred CF mutations that have varying degrees of severity. The most common mutation, df508, can cause failure to thrive in infants, recurrent and very serious lung infections during childhood and often pancreatic insufficiency in children. While early diagnosis and preventive treatment have improved, CF is still a fatal disease. ...Read more

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In what way is cystic fibrosis inherited?

In what way is cystic fibrosis inherited?

CF is recessive: Cystic fibrosis is a disorder passed thru the genes of both parents, silent in the carrier parent & expressed in the affected kid who has inherited an affected gene from both parents. One mutation (delta 509) is the most common but others occur and variations in intensity do occur. I believe you can have carrier testing to see if u carry a gene, then avoid a starting a pregnancy with another carrier. ...Read more

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What is cystic fibrosis? How is it inherited?

What is cystic fibrosis? How is it inherited?

CF is recessive: Cystic fibrosis is a disorder passed thru the genes of both parents, silent in the carrier parent & expressed in the affected kid who has inherited an affected gene from both parents. One mutation (delta 509) is the most common but others occur and variations in intensity do occur. The defect produces a variety of serious changes primarily in the lungs and digestive tract impairing life. ...Read more

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What is cystic fibrosis? How is it inherited?

What is cystic fibrosis? How is it inherited?

CF is recessive: Cystic fibrosis is a disorder passed thru the genes of both parents, silent in the carrier parent & expressed in the affected kid who has inherited an affected gene from both parents. One mutation (delta 509) is the most common but others occur and variations in intensity do occur. The defect produces a variety of serious changes primarily in the lungs and digestive tract impairing life. ...Read more

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Are there official recommendations for treating cystic fibrosis?

CF center: The usual suggestion for those with CF is to get treated at a CF center (a center accredited by the CF foundation) that has a multidisciplinary clinic. Nutrition, exercise, pulmonary toilet, and medications vary by age, lung function, and other problems and should be individualized. Http://www. Cff. Org/livingwithcf/carecenternetwork/cffoundation-accreditedcarecenters/ can help you find one. ...Read more

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What are the causes of differences in the severity of cystic fibrosis?

What are the causes of differences in the severity of cystic fibrosis?

Different mutations: Mutations in the cftr gene cause cystic fibrosis. The cftr gene provides instructions for making a channel that transports negatively charged particles called chloride ions into and out of cells. More than 1, 000 different mutations in the cftr gene have been identified in people with cystic fibrosis. Depending on the which mutations and other genetic factors, this leads to variability of disease. ...Read more

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What is advanced liver fibrosis?

What is advanced liver fibrosis?

Cirrhosis: Another term will be cirrhosis or replacement of normal tissue by scar tissue. ...Read more

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My friend vomited approximately 3 bags of blood. Then, he went for fibroscan and the result showed severe fibrosis. What is this and what is the cur?

My friend vomited approximately 3 bags of blood. Then, he went for fibroscan and the result showed severe fibrosis. What is this and what is the cur?

Friend is very sick: No system of the body is spared in cirrhosis / end-stage liver disease. Will see general deterioration, endocrine problems, cardiovascular, GI (diarrhea, gastropathy, bleeding varices) pancreatic-biliary, neurologic, hematologic (coagulopathy ; bone marrow abnormalities), lung (hepatopulmonary), kidney (hepatorenal), lymphatic, dermatologic, musculoskeletal, ; higher risks of cancer. ...Read more

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What is treatment for fibrosis of marrow, and what are chances of survival?

The prognosis in: Myelofibrosis can be quite variable. There is a scoring system which would be of help in an individual case. Talk to your doc about the specifics of your case. ...Read more

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What is pulmonary fibrosis?

What is pulmonary fibrosis?

Scar tissue: The short version is scar tissue caused by inflammation in the lung. There are many different causes and subtypes though making it pretty complicated. ...Read more

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What is pulmonary fibrosis?

What is pulmonary fibrosis?

See below: It's a spectrum of diseases that cause a scarring of the lung. There are many causes from not knowing what causes it, to medications, dust exposure, autoimmune diseases, etc. Some of the types of fibrosis are progressive, some aren't. Some respond to treatment and some do not. ...Read more

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Is pulmonary fibrosis terminal?

Not good news: Pulmonary fibrosis means that the patient has developed abnormal tissue formation (fibrosis) that affects the thin membranes separating the air sacs from the blood vessels making it harder for oxygen to cross from air to the red bleed cells. This disease usually irreversible; it is critical to have an early diagnosis and be managed at an institution and by medical staff familiar with it. ...Read more

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Is pulmonary fibrosis inherited?

Is pulmonary fibrosis inherited?

Pulmonary fibrosis: While I have not seen it commonly there are some families with a history of pulmonary fibrosis. Most of my office patients and previous fibrosis patients I have come across are the only ones in their family with fibrosis. I have one patient in my practice with several family members with progressive and ultimately fatal fibrosis. She has been evaluated at duke university with a genetic workup. ...Read more

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What is pulmonary fibrosis like?

Scarring: Idiopathic pulmonary fibrosis is an inflammatory process affecting lung parenchyma and resulting in loss of lung storage and resulting in low diffusin capacity and restrictive lung disease. Cardiovascular effect inckude pulmonary hypertension and cor pulmonale. The disease is slowly progressive and unresponsive to all current therapy. Lifespan can be in months (hamman-rich) to a few years. ...Read more

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How is pulmonary fibrosis treated?

How is pulmonary fibrosis treated?

Depends...: It really depends on the type. If you're talking about idiopathic pulmonary fibrosis, there's a new drug called pirfenidone. It slows the progression but it isn't curative. ...Read more