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Doctor insights on: Fibrinogen Storage Disease

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Dr. Raymond Migrino
390 doctors shared insights

Fibrinogen (Definition)

Is a key element of the clotting cascade. It is the precursor to fibrin. The conversion ...Read more


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Does iron intake affect coronary artery disease?

Does iron intake affect coronary artery disease?

Shouldn't: I have never heard of iron supplementation affecting the course of coronary artery disease. Too much iron can effect the myocardium, however, even in that case, it usually is not the oral supplementation but a different process that leads to the damage (cardiomyopathy). ...Read more

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Is atherosclerosis an autoimmune deficiency disorder?

Is atherosclerosis an autoimmune deficiency disorder?

No: No, it isn't; steroids don't help; in fact they hurt.Immunopressives don't help either. ...Read more

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What causes elevated calcitriol (108.5 pg/mL) with elevated serum Ca, normal PTH. No granuloma disease.

What causes elevated calcitriol (108.5 pg/mL) with elevated serum Ca, normal PTH. No granuloma disease.

Measure 25(OH)D: Calcitriol, 25(OH)2D, is usually elevated in granulomatous diseases such as sarcoidosis, in lymphomas or in primary hyperparathyroidism, as you suggest. Calcitriol is quite influenced by intestinal absorption of calcium; 25(OH)D is the vitamin D metabolite usually measured (not DI-hydroxy/2D). Add a 25(OH)D measurement & work with your doctor to pursue the other causes of hypercalcemia. Good luck! ...Read more

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Is autoimmune hepatitis connective tissue disorder?

Is autoimmune hepatitis connective tissue disorder?

No: Autoimmune hepatitis is an inflammatory condition that effects the liver cells. Antibodies from a patient's own immune system attack the cells of the liver. ...Read more

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Why do wilson disease patient have a low ceruloplasmin level? Is it due to wilson disease itself or low production by liver?

Why do wilson disease patient have a low ceruloplasmin level? Is it due to wilson disease itself or low production by liver?

Minor mystery: We do know that the liver tends to underproduce ceruloplasmin in Wilson's, but this is only the case in about 2/3 of patients and it is famously unreliable as a way of screening. The exact mechanisms still haven't been sorted out. ...Read more

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What disease is caused by defective hemoglobin proteins?

What disease is caused by defective hemoglobin proteins?

Hemiglobinopathies: There are hundreds of these, from trivial to diseases that are so severe they kill before birth. ...Read more

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Confused by lab results.Dr thinking rheumatoid arthritis. Low hem, hemotricot, mcv,mch,mchc,creatine.High platelet,rdw,esr,c reactive protein. ?

Confused by lab results.Dr thinking rheumatoid arthritis. Low hem, hemotricot,  mcv,mch,mchc,creatine.High platelet,rdw,esr,c reactive protein. ?

You have anemia of: the chronic diseases which includes RA. Get a CCP antibody test to put aside the confusion for good. If CCP antibody is positive then your doctor probably made the right diagnosis which is RA. If you have still doubts or has queries and want to send me an e-mail click here --> https://www.healthtap.com/experts/12714048-dr-vahe-yetimyan ...Read more

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Which disease is deadlier: chronic bronchitis or kidney disease (stage 4)?

Which disease is deadlier: chronic bronchitis or kidney disease (stage 4)?

Kidney ds/more info: It is difficult to determine from the information provided. Stage 4 kidney disease is severe but most forms of chronic bronchitis can be managed. ...Read more

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Wouldn't malnutrition due to Crohn's disease cause an abnormal Prealbumin blood level?

Wouldn't malnutrition due to Crohn's disease cause an abnormal Prealbumin blood level?

Pre-albumin / Crohns: Yes depending on level of inflammation in crohns disease. As a gastroenterologist I use pre-albumin in conjunction with other blood tests to see how my patients are responding to therapy. If inflammation is poorly controlled pre-albumin is usually low. ...Read more

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Why coes serum aminotransferase increase in liver disease like viral hepatitis ?

Inflammation: When there is inflammation in the liver as a result of an insult, liver tests can become elevated. ...Read more

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Which one is a more trusted marker for copper deficiency anemia - 1. Serum Copper levels or 2. Serum Ceruloplasmin level?

Which one is a more trusted marker for copper deficiency anemia - 1. Serum Copper levels or 2. Serum Ceruloplasmin level?

Serum copper, but...: "Copper deficiency anemia" is extremely rare. If you're actually being screened for Wilson's, which is quite common, it's a different story -- urine copper is preferable to either. If you're not overdoing oral zinc & haven't had bypass surgery, this is an extreme long shot needing a very low serum copper and confirmation with a bone marrow study. ...Read more

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Liver biopsy: PAS:Glycogenated hepatocytes PAS w diastase: no hyaline globules No stainable iron Does this rule out fatty liver or liver disease?

Liver biopsy:
PAS:Glycogenated hepatocytes 
PAS w diastase: no hyaline globules
No stainable iron
Does this rule out fatty liver or liver disease?

Not all diseases: It rules deposition of iron and carbohydrates. The description does not mention fat. At times biopsy may not contain lesions present elsewhere in the organ. It would be prudent to discuss it with your doctor and better yet with your doctor and the pathologist who reviewed the biopsy. ...Read more

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Does a normal serum copper level and serum ceruloplasmin level of 21 rule out wilson's disease? Have fatty liver with zero risk factors & mansymptoms

No: Diagnosing wilson's is treacherous and i'd ask about a urinary copper. About 1/4 of wilson's patients will have normal serum ceruloplasmin, and the serum copper is even less reliable. ...Read more

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Is sickle cell disease genetic?

Is sickle cell disease genetic?

Yes: The recessive sickle gene is carried silently in a percentage of the population.When two carriers produce offspring their is 25% risk with each conception that an affected baby will be born. ...Read more

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Is e heart disease hereditary?

Is e heart disease hereditary?

Heart disease : Yes certain forms of heart disease are genetic. ...Read more