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Doctor insights on: Fibrate

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What's the best time to take fibrate if I also take a statin?

What's the best time to take fibrate if I also take a statin?

No best time: I am not a big fan of fibrates. Especially in combination with statin. If you have to take both use very low dose statin.Combination increases risk for myopathy. Recommend to avoid combination in advanced age (> 65 years), impaired renal function (gfr < 30 ml/min), hepatic disease, females, hypothyroidism, small muscle mass. ...Read more

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What's the best time to take fibrate if I also take a statin?

No best time: I am not a big fan of fibrates. Especially in combination with statin. If you have to take both use very low dose statin.Combination increases risk for myopathy. Recommend to avoid combination in advanced age (> 65 years), impaired renal function (gfr < 30 ml/min), hepatic disease, females, hypothyroidism, small muscle mass. ...Read more

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What are known side effects of ppar agonists? Like fibrates etc..

What are known side effects of ppar agonists? Like fibrates etc..

Fibrate Side Effect: Myotoxicity (muscle damage, rhabdo) is one, especially when used with statins. Liver enzyme elevation is not uncommon. Creatinine (a kidney lab #) elevation may be seen but not necessarily bad; pancreatitis may be seen, extremely rare. Other serious but extremely rare side effects are possible. Generally safe when doctor prescribed & monitored. Muscle aches = stop & call dr asap; + dark urine=>er. ...Read more

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Can we reduce cholesterol levels without medicines, onlly with exercise, because when i take stations are fibrates iam having severe body pain.

Can we reduce cholesterol levels without medicines, onlly with exercise, because when i take stations are fibrates  iam having severe body pain.

Nuts: Read the Harvard Nut Study online. It has been definitively shown that eating 1-2 handfuls of nuts daily will lower your total & LDL cholesterol and triglycerides. This will also raise your HDL cholesterol. Almonds and English walnuts are thought to work best. Even peanuts which are legumes, not tree nuts will work. I encourage patients to get a big container of mixed nuts and eat 1-2 handfuls/d. ...Read more

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Which meds besides statins and fibrates to treat high cholesterol?

It's not a statin.: Zetia (ezetimibe) is a cholesterol absorption blocker. By itself, it can lower LDL levels by 18%, which is relatively weak compared to some statins. However, when combined with a statin, it can give much more significant LDL lowering. Ask your doctor if this medication is right for you. Welchol (colesevelam) is a cholesterol absorption blocker of a different type, which may also be effective. ...Read more

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Tc 240, trig 45, HDL 85, LDL 146. Intolerant of statins, fibrates, Zetia (ezetimibe) and niacin.Diet good, exercise and take fish oil. Any other therapies?

Tc 240, trig 45, HDL 85, LDL 146. Intolerant of statins, fibrates, Zetia (ezetimibe) and niacin.Diet good, exercise and take fish oil. Any other therapies?

Find and Fix Causes: High LDL levels may result from overproduction of LDL particles, decreased clearance of LDL particles, or both. In some cases common LDL lowering medications are not sufficient to control high LDL levels. Consideration should be given to identifyihng genetic causes (familial hypercholesterolemia), or acquired medical problems (thyroid, renal, liver, glucose related disorders) that could be present ...Read more

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