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Doctor insights on: Fetal Hemoglobin Sickle Cell

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Some adults with sickle cell anemia have high levels of fetal hemoglobin. Any reason for this?

Some adults with sickle cell anemia have high levels of fetal hemoglobin. Any reason for this?

Epigenetics and drug: We know that sickle cell patients that have increased Hemoglobin F typically have less sickle cell complications. This is the basis for using Hydroxyurea in sickle cell patients. Some individuals have elevated Hemoglobin F levels due to differences in the genetic region of the beta and gamma globin genes that prevent the normal shutting-off of the gamma globin gene. This leads to increased HGB f. ...Read more

Dr. Vijay Sankaran
114 doctors shared insights

Fetal Hemoglobin (Definition)

Is the main hemoglobin that transport oxygen in the fetus during the last seven months of development in the uterus and in the newborn until roughly 6 months old. , fetal hemoglobin is able to bind oxygen with greater affinity than the adult hemoglobin, giving the developing fetus better access to oxygen ...Read more


Emily Lu Dr. Lu
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How common is the inherited persistence of fetal hemoglobin?

Emily Lu Dr. Lu
1 doctor agreed:
How common is  the inherited persistence of fetal hemoglobin?

Difficult to measure: This is difficult to measure because in most people with inherited persistence of fetal hemoglobin are entirely asymptomatic. However, population studies have shown that about 10% of the population has been seen to have some persistence of fetal hemoglobin but in varying levels (from 0.8% of cells containing the fetal hemoglobin up to about 10% fetal hemoglobin levels). ...Read more

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What are the risks for the patient in undergoing a fetal hemoglobin test?

What are the risks for the patient in undergoing a fetal hemoglobin test?

Blood test: This is just a blood test. The risks are the same for any blood testing, such as bruising and the needle site. ...Read more

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I have elevated levels of fetal hemoglobin. What can cause this? I am not pregnant. Does it point to a disorder?

I have elevated levels of fetal hemoglobin. What can cause this? I am not pregnant. Does it point to a disorder?

Not necessarily: Elevated fetal hemoglobin may represent what is known as persistence of fetal hemoglobin. It would be helpful to know what the percentages of various hemoglobins are in your electrophoresis, This may be normal for YOU or it could represent a topic which needs investigation. Please speak to your doctor. Good luck! ...Read more

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What is the definition or description of: fetal hemoglobin?

What is the definition or description of: fetal hemoglobin?

Hb F: Is the main hemoglobin that transport oxygen in the fetus during the last seven months of development in the uterus and in the newborn until roughly 6 months old. , fetal hemoglobin is able to bind oxygen with greater affinity than the adult hemoglobin, giving the developing fetus better access to oxygen from the mother's bloodstream. ...Read more

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How to find how much larger kc is for fetal hemoglobin than adult hemoglobin?

Unclear question: Fetal and adult hemoglobin are about the same size. Fetal Hb binds oxygen more tightly. ...Read more

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Is abnormal hemoglobin is a key characteristic of sickle cell anemia?

Is abnormal hemoglobin is a key characteristic of sickle cell anemia?

Yes: With ss disease a genetic mutation changes the gene sequencing needed for normal hemoglobin production.The alteration changes the way the hemoglobin handles the oxygen molecule as it carries it in the blood.The blood cell then becomes distorted in the small capillaries and the spleen.The cell breaks down rapidly and or remains trapped.Anemia is a chronic problem. ...Read more

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I know that the typical test for sickle-cell anemia is a hemoglobin electrophoresis, but will you be able to see the sickle shape of the blood cells?

I know that the typical test for sickle-cell anemia is a hemoglobin electrophoresis, but will you be able to see the sickle shape of the blood cells?

Yes: Sick led cells are readily seen on a peripheral blood smear. It's worth knowing that the irreversibly sick led cells that you see on a smear are not necessarily the ones that cause the problem. In order for a cell at risk for sickling to occlude the small blood vessels (capillaries), they first must be able to enter them. In other words they must be deformable. They become occlusive in the vessel. ...Read more

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Was tested for sickle cell and the trait. I do not have either one. But I have high hemoglobin s & low a. What other than sickle cell can cause this?

Was tested for sickle cell and the trait. I do not have either one. But I have high hemoglobin s & low a. What other than sickle cell can cause this?

Sickle beta thal: If you have high HGB s and low HGB a, then you have sickle beta-plus thalassemia ( if you have HGB a1), or sickle beta-zero thalassemia. ( if you have HGB a2 not HGB a1). These are both forms of sickle cell disease not trait. Beta zero is just as severe as homozygous sickle cell anemia (hgb ss); beta plus is milder in terms of symptoms. ...Read more

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What will happen when you have a normal hemoglobin allele and a sickle cell allele?

What will happen when you have a normal hemoglobin allele and a sickle cell allele?

Usually nothing: Sickle cells trait is usually asymptomatic. You may have trouble at high altitude or other low oxygen situations. If you marry a person with sickle cell trait or disease, you risk having a child with sickle cell disease. ...Read more

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Help docs, is hemoglobin AC a sickle cell trait?

Help docs, is hemoglobin AC a sickle cell trait?

No: Hgb AC is a heterozygous genetic state that is not sickle cell trait ( Hgb AS). Patient's with Hgb AC are clinically well with at worst mild asymptomatic anemia (most are not anemic). Individuals with Hgb AC can have children with Hgb SC (a type of severe sickle cell hemoglobinopathy) if their partner has either sickle cell trait (25% chance) or sickle cell disease (50% chance) ...Read more

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Hello, i want to know if there is a defferances in the level of hemoglobin s in the people who has sickle cell trait ,,, ?

Yes: There are variations in the expression of Hb S gene and the depending on additional factors the percentage of Hb S in a person with the trait may vary from about 20-70%. The additional factor generally is beta thalassemia trait in the cis or trans position to the Hb S gene. ...Read more

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How do you test fetus for sickle cell anemia?

How do you test fetus for sickle cell anemia?

Genetic test Sickle: Yes the test is done on high risk women at the 17 week of gestation by doing amniocentesis with the permission of both patents. ...Read more

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What is the cause of sickle cell anemia in fetus?

What is the cause of sickle cell anemia in fetus?

You may be confused.: Fetuses do not suffer from sickle cell anemia in utero because they have a different type of hemoglobin (fetal) that is unaffected even in individuals destined to have sickle cell disease later in life. Affected fetuses come from affected or carrier parents and sickle cell disease is a genetic condition without cure at present. See a genetic counselor to discuss these issues in detail. ...Read more

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Please help! what happens if you have both hemaglobin c trait and sickle cell trait?

Less severe than SS: Hemoglobin sc disease is the second most common type of sickle cell disease. It occurs when you inherit the hb c gene from one parent and the hb s gene from the other. Individuals with hb sc have similar symptoms to individuals with hb ss (sickle cell disease). However, the anemia is less severe. ...Read more

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So I had a normal CBC/FBC blood test, would I need to request for a Haemoglobin S/Sickle Cell Test instead to test for Sickle Cell Disease?

So I had a normal CBC/FBC blood test, would I need to request for a Haemoglobin S/Sickle Cell Test instead to test for Sickle Cell Disease?

Sickle screening: Babies born in California (maybe the entire US) are screened for sickle cell as part of the newborn screen (from collecting a few drops of heel blood). A person can try to find her newborn screen result. To test now, use the "Sickle cell screen, reflex to Hemoglobin analysis," meaning that a positive screening result leads the lab to analyze the blood to see what exact type of abnormality exists. ...Read more

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Can the sickle cell trait cause fetal distress?

Can the sickle cell trait cause fetal distress?

Yes: In a study from the 90's, fetal distress in labour was seen in 17% and 11.5% were delivered by emergency caesarean section. Compared with a comparable group of women without sickle cell trait, the mean birthweight of the babies (3202 g) was not reduced. The main maternal complications were recurrent urinary tract infections (6%) and haematuria (16.5%). ...Read more

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Could sickle-hemoglobin c disease be transmitted through blood?

Could sickle-hemoglobin c disease be transmitted through blood?

No: This is a genetic disease. A donor unit with sickle-c will not be accepted, and even if you were transfused with such a unit, it would not affect you. If you perhaps had a hemoglobin electrophoresis after a transfusion, and it showed some sickle and some c hemoglobin, you may have been transfused from two donors each bearing the trait. ...Read more

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37 year old woman 29 week of pregnant ,high grade fever last 1 week,plecenta slightly displace abnormal fetal movement hemoglobin level low lDh level?

37 year old woman 29 week of pregnant ,high grade fever last 1 week,plecenta slightly displace abnormal fetal movement hemoglobin level low lDh level?

High fever, pregnant: This could be very serious. You require immediate medical attention with high fever for over a week and pregnant. Can you see a doctor, or go to a hospital or clinic as soon as possible. ...Read more

Dr. James Ball
354 doctors shared insights

Sickle Cell Disease (Definition)

A group of disorders that cause red blood cells to become ...Read more