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Doctor insights on: Fetal Hemoglobin Sickle Cell

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Some adults with sickle cell anemia have high levels of fetal hemoglobin. Any reason for this?

Some adults with sickle cell anemia have high levels of fetal hemoglobin. Any reason for this?

Epigenetics and drug: We know that sickle cell patients that have increased Hemoglobin F typically have less sickle cell complications. This is the basis for using Hydroxyurea in sickle cell patients. Some individuals have elevated Hemoglobin F levels due to differences in the genetic region of the beta and gamma globin genes that prevent the normal shutting-off of the gamma globin gene. This leads to increased HGB f. ...Read more

Dr. James Ball
348 doctors shared insights

Sickle Cell Disease (Definition)

This is a genetic disorder in which hemoglobin is abnormally made., more common in people of african descent. This abnormality causes red blood cells to become stiff and fall apart. This can cause very specific symptoms: pain, pneumonias, strokes, spleen problems, and many other problems. Some have mild disease, some ...Read more


Emily Lu Dr. Lu
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How common is the inherited persistence of fetal hemoglobin?

Emily Lu Dr. Lu
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How common is  the inherited persistence of fetal hemoglobin?

Difficult to measure: This is difficult to measure because in most people with inherited persistence of fetal hemoglobin are entirely asymptomatic. However, population studies have shown that about 10% of the population has been seen to have some persistence of fetal hemoglobin but in varying levels (from 0.8% of cells containing the fetal hemoglobin up to about 10% fetal hemoglobin levels). ...Read more

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What are the risks for the patient in undergoing a fetal hemoglobin test?

What are the risks for the patient in undergoing a fetal hemoglobin test?

Blood test: This is just a blood test. The risks are the same for any blood testing, such as bruising and the needle site. ...Read more

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I have elevated levels of fetal hemoglobin. What can cause this? I am not pregnant. Does it point to a disorder?

I have elevated levels of fetal hemoglobin. What can cause this? I am not pregnant. Does it point to a disorder?

Not necessarily: Elevated fetal hemoglobin may represent what is known as persistence of fetal hemoglobin. It would be helpful to know what the percentages of various hemoglobins are in your electrophoresis, This may be normal for YOU or it could represent a topic which needs investigation. Please speak to your doctor. Good luck! ...Read more

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What is the definition or description of: fetal hemoglobin?

What is the definition or description of: fetal hemoglobin?

Hb F: Is the main hemoglobin that transport oxygen in the fetus during the last seven months of development in the uterus and in the newborn until roughly 6 months old. , fetal hemoglobin is able to bind oxygen with greater affinity than the adult hemoglobin, giving the developing fetus better access to oxygen from the mother's bloodstream. ...Read more

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How to find how much larger kc is for fetal hemoglobin than adult hemoglobin?

Unclear question: Fetal and adult hemoglobin are about the same size. Fetal Hb binds oxygen more tightly. ...Read more

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Is abnormal hemoglobin is a key characteristic of sickle cell anemia?

Is abnormal hemoglobin is a key characteristic of sickle cell anemia?

Yes: With ss disease a genetic mutation changes the gene sequencing needed for normal hemoglobin production.The alteration changes the way the hemoglobin handles the oxygen molecule as it carries it in the blood.The blood cell then becomes distorted in the small capillaries and the spleen.The cell breaks down rapidly and or remains trapped.Anemia is a chronic problem. ...Read more

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I know that the typical test for sickle-cell anemia is a hemoglobin electrophoresis, but will you be able to see the sickle shape of the blood cells?

I know that the typical test for sickle-cell anemia is a hemoglobin electrophoresis, but will you be able to see the sickle shape of the blood cells?

Yes: Sick led cells are readily seen on a peripheral blood smear. It's worth knowing that the irreversibly sick led cells that you see on a smear are not necessarily the ones that cause the problem. In order for a cell at risk for sickling to occlude the small blood vessels (capillaries), they first must be able to enter them. In other words they must be deformable. They become occlusive in the vessel. ...Read more

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Was tested for sickle cell and the trait. I do not have either one. But I have high hemoglobin s & low a. What other than sickle cell can cause this?

Was tested for sickle cell and the trait. I do not have either one. But I have high hemoglobin s & low a. What other than sickle cell can cause this?

Sickle beta thal: If you have high HGB s and low HGB a, then you have sickle beta-plus thalassemia ( if you have HGB a1), or sickle beta-zero thalassemia. ( if you have HGB a2 not HGB a1). These are both forms of sickle cell disease not trait. Beta zero is just as severe as homozygous sickle cell anemia (hgb ss); beta plus is milder in terms of symptoms. ...Read more

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Dr. Vijay Sankaran
114 doctors shared insights

Fetal Hemoglobin (Definition)

Is the main hemoglobin that transport oxygen in the fetus during the last seven months of development in the uterus and in the newborn until roughly 6 months old. , fetal hemoglobin is able to bind oxygen with greater affinity than the adult hemoglobin, giving the developing fetus better access to oxygen ...Read more