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Doctor insights on: Fetal Alloimmune Thrombocytopenia

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Neonatal alloimune thrombocytopenia treatment?

Neonatal alloimune thrombocytopenia treatment?

Platelet transfusion: If the fetus has an antigen on platelets that the mother lacks, she may make antibodies that destroy the fetal platelets. Infusing platelets that lack the antigen is the treatment. Platelets can be infused into the fetus in utero, if needed, . ...Read more

Dr. Liawaty Ho
1,061 doctors shared insights

Thrombocytopenia (Definition)

A condition characterized by abnormally low levels of thrombocytes, also known as ...Read more


Dr. Jay Park Dr. Park
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Neonatal alloimune thrombocytopenia, what is this?

Dr. Jay Park Dr. Park
1 doctor agreed:
Neonatal alloimune thrombocytopenia, what is this?

Low platelets count: Neonatal alloimmune thrombocytopenia occurs when fetal platelets contain an antigen inherited from the father that the mother lacks. The mother forms antiplatelet antibodies against the this antigen; these cross the placenta and destroy fetal platelets, resulting in fetal and neonatal thrombocytopenia. Minority of affected newborns (about 20%) experiences severe bleeding including intracranial bl ...Read more

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What does Neonatal alloimune thrombocytopenia mean?

What does Neonatal alloimune thrombocytopenia mean?

NAT: Neonatal (fetus or newborn under 1 month) alloimmune (immune response to foreign antigen) thrombocytopenia (low platelet count). NAT occurs when substances from mother's body pass into the baby's system, causing destruction of platelet cells. ...Read more

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Difference between idiopathic thrombocytopenia purpura and thrombotic thrombocytopenia purpura?

Difference between idiopathic thrombocytopenia purpura and thrombotic thrombocytopenia purpura?

The are completely: Different. Itp is the autoimmune destruction of platelets and is managed with immunosuppression - the first line is usually prednisone. Ttp is the microvascular consumption of platelets (small clots). This can be associated with anemia, renal failure, ha and fever. It is a medical emergency and is managed with plasma exchange. ...Read more

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Dr. Liawaty Ho Dr. Ho
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Does itp (immune thrombocytopenic purpura) weaken the immune system?

Dr. Liawaty Ho Dr. Ho
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Does itp (immune thrombocytopenic purpura) weaken the immune system?

No: Itp does not supress immune system. Itp is treated commonly with immunesupressive agents such as corticosteroids, rituxan- and thse treatment would supresse immune system. ...Read more

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Is autoimmune hemolytic anemia hereditary?

Is autoimmune hemolytic anemia hereditary?

No: It can be due to an underlying autoimmune disorder, such as lupus or rheumatoid arthritis. In this case, the underlying autoimmune disorder may be hereditary; but the autoimmune hemolytic anemia is not hereditary. It is simply the manifestation of the underlying disorder. There are also several causes of autoimmune hemolytic anemia that are not inherited. ...Read more

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Itp - idiopathic thrombocytopenic purpura, what is this?

Itp - idiopathic thrombocytopenic purpura, what is this?

ITP is just what...: It sounds like. It is characterized by bleeding, bruising (purpura) and petechiae that develop because of a low PLT count (aka thrombocytopenia), and where the specific trigger for thrombocytopenia is not known (idiopathic). We do know that in itp, the pt makes antibodies to auto-antigens found on the PLT surface (often pla-1) which mark them for destruction. This makes the PLT count low. ...Read more

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Does autoimmune hemolytic anemia affect WBC ?

Does autoimmune hemolytic anemia affect WBC
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Not usually: It depends on the type of autoimmune disorder. In most cases autoimmune hemolytic anemia does not affect WBC. But some autoimmune disorders like SLE may cause hemolytic anemia and neutropenia as well. ...Read more

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Thyroid Peroxidase Antibodies 274.0 Anti-Thyroglobulin Antibody 164.4 Mean Platelet Volume 9.1 Erythrocyte Sed Rate 26 Estimat Glomerular Filtratio 43?

Thyroid Peroxidase Antibodies 274.0
Anti-Thyroglobulin Antibody 164.4
Mean Platelet Volume 9.1
Erythrocyte Sed Rate 26
Estimat Glomerular Filtratio 43?

Thyroid and kidneys: Hi. You have antibody evidence of thyroid autoimmunity. It would be nice to know your TSH and free T4. Are you on thyroid hormone? You have diminished kidney function. Do you know why? ...Read more

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What is the disease ?Thrombotic thrombocytopenia purpura?

What is the disease ?Thrombotic thrombocytopenia purpura?

Abnormal platelet: Function due to deficiency of a metaloproteinase. Deficiency, usually acquired, of an enzyme that breaks down large multimers of von willebrand factor causes overactivation of platelets leading to intravascular microthrombi that affect the functions of the kidneys, brain, lungs and other organs. It can be treated by transfusing normal donor plasma. ...Read more

Dr. Liawaty Ho Dr. Ho
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Unexplained high platelets (572), WBC (17.2), leukocytes, neutrophils, low hemaglobin. Bone marrow, jak2 and lupus test negative, ANA positive. Help?!

Dr. Liawaty Ho Dr. Ho
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Unexplained high platelets (572), WBC (17.2), leukocytes, neutrophils, low hemaglobin. Bone marrow, jak2 and lupus test negative, ANA positive. Help?!

Reactive/ autoimmune: Discuss further with your hematologist. Certain conditions like iron deficiency , infection /inflammation vs autoimmune vs. Other solid tumor need to be ruled out. Need to check iron level, bcr/abl, imaging study like ct scan chest /abd/ pelvis will be needed. If you smoke - will suggest you to quit smoking., need to do work - up to find the anemia as well. If iron is low - GI w/u is needed. ...Read more

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Is thre any treatment for idiopathic thrombocytopenic purpura itp in pregnancy?

Yes.: Itp in pregnancy is treatable. It does depend on what medications have worked in the past. If the itp has never been treated, there are several options. Steroids are often used in pregnancy. The itp, even if treated in the mom, can cause low platelets in the newborn. This may be of more concern if mom has had her spleen removed or if othersib, inge have had trouble with low platelets at birth. ...Read more

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Is erythroblastosis fetalis is an example of autoimmunity or isoimmunity?

Is erythroblastosis fetalis is an example of autoimmunity or isoimmunity?

Alloimmunity: Autoimmunity is an immune response to one's own proteins while the example of Erythroblastosis fetalis is an immune response of mom's antibodies to a foreign antigen, this case from the fetus. ...Read more

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Idiopathic autoimmune hemolytic anemia - what are the chances of dying?

Idiopathic autoimmune hemolytic anemia - what are the chances of dying?

Uncommon. : This would be very uncommon. But it can happen. Definitely take the prescribed medicine and follow up with your doctor regularly. ...Read more

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Is neonatal sepsis related to hbo incompatibility?

Neonatal sepsis: No it is caused from infection and has nothing to do with ABO incompatibilty. ...Read more

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What are the risks of disseminated intravascular coagulation after a single fetal demise @ 28 weeks. This a triplet pregnancy - trichorion/triamnio?

What are the risks of disseminated intravascular coagulation after a single fetal demise @  28 weeks.
This a triplet pregnancy - trichorion/triamnio?

I am truly sorry: for a loss of one of your Fetus. At 28 weeks with the advent of Modern medicine and Technology survival rate of other fituses are 100%. All the best ...Read more

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Ferritinin 800, iron 167. And macrocytic anemia. Liver , kidney, wbc, platelets, neutrophil, B12 normal. Why? Is it preleukemia?

Ferritinin 800, iron 167. And macrocytic anemia. Liver , kidney, wbc, platelets, neutrophil, B12 normal. Why? Is it preleukemia?

At least 2 problems: You realize that we can't diagnose you. With the very high serum ferritin and up-there serum iron, assuming the blood was not drawn during an acute illness, you have hemochromatosis until proved otherwise. How anemic you are, whether this is real macrocytosis, what your physical findings and other labs are are best known to your hematology consultation. Hope nobody gave you iron supplements. ...Read more

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Pediatrics. IGM0.43 WBC4.1 RBC3.60 PLATELETS120 MCV107.0 MCH34.5 NEUTROPHIL0.66 MONOCYTE0.04 BRUISING EASY does this indicate MDS or APLASTIC AMENIA?

Pediatrics. IGM0.43 WBC4.1 RBC3.60 PLATELETS120 MCV107.0 MCH34.5 NEUTROPHIL0.66 MONOCYTE0.04 BRUISING EASY does this indicate MDS or APLASTIC AMENIA?

Easy bruise: These results do not point to an aplastic condition because there is normal WBC count and adequate platelets. They should have done labs for bleeding diathesis such as Prothrombin time(PT/INR) and Partial thromboplastin time (PTT) as well as possible blood clotting factor levels. ...Read more

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In the case of idiopathic thrombocytopenia purpura is pregnancy dangerous?

In the case of idiopathic thrombocytopenia purpura is pregnancy dangerous?

High risk pregnancy: It is something that is manageable, however. You should see a perinatologist for your high risk pregnancy to make sure your baby is okay and also see a hematologist through out your pregnancy- to make sure you and baby are okay. Your hematologist will be able to help and give you the necessary treatment as indicated- like-platelet transfusion, ivig, steroid etc. ...Read more