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Doctor insights on: Family History Of Pernicious Anemia

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I tested positive for ana, and have a family history of lupus and pernicious anemia. What do I do now?

I tested positive for ana, and have a family history of lupus and pernicious anemia. What do I do now?

Wait: Many normal people have low-titer positive ana's and they mean nothing by themselves. If you have symptoms suggestive of lupus, continue the workup and consider seeing a rheumatologist. If you have a family history of pernicious anemia, you'd do well to get a serum B12 assay every few years. ...Read more

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Pernicious Anemia (Definition)

It is a decline in the amount of red cells in the circulation as a result of impaired production in the bone marrow resulting from a lack of vitamin b12. This is most commonly as a consequence of impaired absorption due to an autoimmune condition affecting the stomach lining. If untreated, it may also lead to brain and spinal cord problems. It is easily ...Read more


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Is there a specific blood test to diagnose pernicious anemia? I have a family history. My doctor told me I have borderline B12 deficiency.

Is there a specific blood test to diagnose pernicious anemia?  I have a family history. My doctor told me I have borderline B12 deficiency.

Pernicious anemia: Yes your doctor can run a battery of tests including a cbc, peripheral blood smear, a serum b 12 level, and a reticulocyte count. These usually will help to diagnose the condition. Sometimes methylmalonic acid and homocysteine levels will be drawn to help with the diagnosis. ...Read more

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Does pernicious anemia run in families?

Rarely: Most cases of pernicious anemia are acquired due to immune destruction of the stomach cells which produce intrinsic factor. This results in poor absorption of B12 from food and patients get anemic as a result. Only rarely can children get this as a congenital causes. ...Read more

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Does hashimoto's run in families? And does it have potential to cause pernicious anemia?

Does hashimoto's run in families? And does it have potential to cause pernicious anemia?

Yes! To both!!: Both may be autoimmune diseases and frequently are hereditary! Both are very easily diagnosed by lab tests! See your physician if you think you have either of these illnesses! ...Read more

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What symptoms of pernicious anemia are the most common?

What symptoms of pernicious anemia are the most common?

Fatigue: In pernicious anemia, there is no vitamin B12 absorption which causes low red blood cell production and leads to severe anemia. This causes fatigue most comonly. ...Read more

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How to treat pernicious anemia?

How to treat pernicious anemia?

B-12 deficiency: Unless there is an intestinal parasite, we usually just do blood studies to confirm and supplement vitamin b-12 using 1000 mcg injected monthly, i.M. Some pts will absorb sufficient amounts by mouth or intranasal routes, but most efficient to inject. ...Read more

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Is there a cure for pernicious anemia?

Yes: Pernnicious anemia is a horrible name for B12 deficiency. It is easily treated by giving injections of B12 or by using inhaled b12. ...Read more

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Does methadone cause pernicious anemia?

Does methadone cause pernicious anemia?

Not likely: Methadone is a very strong opioid medication, with a long list of serious side effects. But pernicious anemia is NOT one of them. Contact your doctor for specific information about your case, re your anemia and specific doses of methadone you are taking. Anemia may be related to other meds you are taking, or an underlying illness. Check with your MD. ...Read more

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Is pernicious anemia genetically caused?

Not usually: Pernicious anemia is caused by vitamin B12 or Folic Acid deficiency. It may be associated with gastrointestinal or liver problems and should be investigated by your physician. ...Read more

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Is methadone a cause of pernicious anemia?

No: Unaware of any association. True pernicious anemia is an autoimmune disease, caused by antibodies to the cells in our stomachs that produce intrinsic factor, which is needed to absorb vitamin B12 from our intestines. It may be hereditary or acquired. There are other causes of B12 deficiency, including stomach and intestinal diseases/surgery, and lack of B12 in diet. A hematologist can help. ...Read more

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Dr. Steven Ginsberg
1,239 doctors shared insights

Anemia (Definition)

Anemia refers to any condition where there is a decrease in the red blood cells in the body. There are numerous causes of anemia but they can basically be broken down into 3 categories: decreased production of red blood cells increased destruction of red ...Read more


Family History (Definition)

A family history consists of information about disorders suffered by the relatives of a patient. The history can help the patient identify diseases that he or she may be susceptible to, and help the patient to ...Read more