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Doctor insights on: Familial Colon Cancer

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Is colon cancer genetic?

Is colon cancer genetic?

Sometimes: Some colon cancers are related to specific genetic mutations but the majority are not. ...Read more

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Dr. Barry Rosen
4,359 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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What is hereditary non-polyposis colorectal cancer (hnpcc) vs familial adenomatous polyposis (fap)?

What is hereditary non-polyposis colorectal cancer (hnpcc) vs familial adenomatous polyposis (fap)?

Both inherited: In fap presents as colonic polyps ( gardners syn will have other tumors ) , autosomal recessive due to mutations in gate keeper, tumor suppres gene. On the contrary hnpcc or lynch syndrome. Is autosomal dominant, due to dna mismatch in repair, associated with other cancers of stomach, endomet. Ca, ovary, brain, skin etc. ...Read more

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Is bowel cancer hereditary?

Is bowel cancer hereditary?

Somehow yes: There is some genetic predisposition in families with hx. Of colorectal cancer. Diet also plays a rol ( low fiber diet increases cancer). Familiar poliposis increases chances of colon cancer. Colon polyps may degenerate in cancer. Small intestine cancers are rare and difficult to find. In general there are families affected by cancers and families affected by atherosclerosis but both together too. ...Read more

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Why is the colon prone to cancer in hnpcc (hereditary nonpolyposis colorectal cancer)?

Why is the colon prone to cancer in hnpcc (hereditary nonpolyposis colorectal cancer)?

Genetic mutations: HNPCC or hereditary nonpolyposis colorectal cancer is an autosomal dominant genetic condition that has a high risk of colon cancer The disease first described by Lynch and is associated with other cancers including endometrial ovary and stomach. The increased risk is due to inherited mutations that impair DNA mismatch repair. .Individuals with HNPCC have an 80% lifetime risk for colon ca. ...Read more

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Is rectal cancer hereditary?

Is rectal cancer hereditary?

Usually not : Most patients with rectal cancer have not inherited it. A small subset have genetic mutations that put them at risk. Probably around 5 % of rectal cancers are hereditary. ...Read more

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Is metastatic colon cancer curable?

Is metastatic colon cancer curable?

Possible: But less than 20% survive 5 years. Depends on where the metastases are and how numerous and size. Solitary liver mets without evidence elsewhere in the body can be cured with a liver resection. Diffuse mets to numerous body parts rarelyare curable. ...Read more

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Is colon cancer curable?

Is colon cancer curable?

Yes: Yes. Many people are cured with colon cancer. If found early surgery alone may be curable. If more advanced (eg, lymph node involvement or metastatic = spread to areas outside of colon), then chemotherapy may be needed. While less likely, even a few % of people with metastatic colon ca may be cured. ...Read more

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Colorectal cancer causes?

Colorectal cancer causes?

Heredity & diet: The cause is not known in most cases. In a small number the cause is clearly heredity, e.g., apc and hnpcc. In the garden variety colon cancer, a diet low in fiber and rich in fats may increase the risk of cancer. ...Read more

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Is pancreatic cancer genetic?

Is pancreatic cancer genetic?

A minority is.: Pancreatic adenocarcinoma, arising from ducts/epithelial tissue, is mainly "sporadic", but can run in families. Pancreatic cancer has also been related to brca mutation, fammm syndrome, and some other inherited conditions. The familial pancreatic cancer registry is at johns hopkins. A minority of neuroendocrine tumors of the pancreas are associated with multiple endocrine neoplasia (men) syndromes. ...Read more

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Is bowel cancer genetic?

Is bowel cancer genetic?

Sometimes: Some colon cancers are related to inheritable genetic mutations but the majority are not. ...Read more

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Is colon cancer preventable?

For the most part.: Early detection via colonosocpy, not ignoring symptoms such as bleeding, change in bowels, anemia, unintentional weight loss, and not assuming all rectal bleeding is from hemorrhoids are some ways to reduce your chances and maybe prevent colon cancer from developing. ...Read more

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Dr. Mark Pack Dr. Pack
3 doctors agreed:
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Is colon cancer fatal?

Dr. Mark Pack Dr. Pack
3 doctors agreed:
Is colon cancer fatal?

Not Necessarily: It depends on the stage at diagnosis and the treatment obtained. ...Read more

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Are breast cancer and colon cancer linked?

Are breast cancer and colon cancer linked?

Not directly usually: There is debate about how closely these 2 cancers are related. Both have hereditary natures and are more common generally in obese patients. Both often begin with more benign precursor lesions like dcis for breast cancer and benign polyps for colon cancer. Both are very common but there is little evidence that having either predisposes to having the other. ...Read more

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Colon cancer chemo necessary?

Depends on stage: Chemotherapy is never used for stage 1 cancers (early). It is sometimes used in stage 2 cancers (early but more advanced than stage 1). Chemotherapy is definitely beneficial in stage 3 cancers (locally advanced) and in stage 4 cancers (distant spread). ...Read more

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Large intestinal cancer. Is that colon cancer?

Large intestinal cancer. Is that colon cancer?

Yes: The large intestine and the colon are words to describe the same anatomic structure in the abdomen. ...Read more

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Is colon cancer fast-growing?

Is colon cancer fast-growing?

Can be: The fastest-growers are the ones that follow genetic pathways associated with the lynch loci. They may not even be preceded by a polyp -- colonoscopy can be clean one year, and a year later, there's a cancer. That's actually quite fast as cancers go. Hope this helps. ...Read more

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How is colon cancer inherited?

How is colon cancer inherited?

Genes: Most colon cancers are not inherited. However, there is a subset which is associated with inherited genetic abnormalities such as hereditary polyposis a this hereditary non polyposis gene (hnpp). There are also syndromes that make you susceptible to a variety of different cancers including colon cancer such as lynch syndrome. ...Read more

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Is liver cancer hereditary?

It can be: Many factors can increase one's risk for primary liver cancer including: chronic infection with hepatitis b or c virus, type 2 diabetes, nonalcoholic fatty liver disease, heavy alcohol use, obesity, exposure to certain toxins, and inherited liver diseases that can lead to cirrhosis such as hemochromatosis, wilson's disease, tyrosinemia, Alpha 1-antitrypsin deficiency, glycogen, and porphyria. ...Read more

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Is lung cancer hereditary?

Is lung cancer hereditary?

Unclear: Non or never smokers can develop lung cancer if they have a genetic mutation to such genes as egfr or eml4/alk fusion translocation. For more info: http://bit.Ly/ygfoko. ...Read more

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For what reason colon part is usually prone to cancer in hnpcc (hereditary hereditary nonpolyposis colorectal cancer)?

Genetic disorder: Hnpcc also called lynch syndrome results from at least four type of genetic defects involving genes needed for repair of damaged dna. See this site for more info. http://ghr.nlm.nih.gov/condition/lynch-syndrome. ...Read more

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If a colon needs to be removed because of colon cancer are their alternatives to a external bag?

If a colon needs to be removed because of colon cancer are their alternatives to a external bag?

Bag is rarely needed: Colostomy( external bag ) is rarely needed for elective cancer surgery. It is more frequently used if the cancer is located very close to the anus, Also, a temporary colostomy may be used for emergency surgery when cancer is obstructing colon completely and the bowel cannot be cleaned prior to the surgery. ...Read more

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What gene do I need to get tested for the familial colon cancer?

What gene do I need to get tested for the familial colon cancer?

Need more info: Totally different genes predispose to colon cancer, including BRCA 1 and 2; Familial Adenomatous Polyposis develops so many polyps in the colon they may be too numerous to count--but this one is quite rare. The commonest is Hereditary Non-Polyposis Colon Cancer. You may be at increased risk if close family members have developed it. See http://www.hopkinscoloncancercenter.org/CMS/CMS_Page.aspx? ...Read more

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Life expectancy of colon cancer==similar to parent if familial?

Life expectancy of colon cancer==similar to parent if familial?

Yes and no: If you a have a true familial form (generally this means multiple 1 st degree relatives have it. Usually happens at an earlier age) then yes the course of disease is similiar. If by familial you mean 1 relative had it, then no it is variable and progress differently. ...Read more

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Is it still possible for me to have familial adenomatous polyposis if parent had colon cancer?

Is it still possible for me to have familial adenomatous polyposis if parent had colon cancer?

Yes if parent has it: Yes if parent had colon cancer due to familial adenomatous polyposis, you could have inherited, only way to rule out is to see your physician , and have a colonascopy done. ...Read more

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Dr. Liawaty Ho Dr. Ho
6 doctors agreed:
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What is colon cancer?

Dr. Liawaty Ho Dr. Ho
6 doctors agreed:
What is colon cancer?

Cancer of the colon: Cancer that forms in the tissues of the colon (the longest part of the large intestine). Most colon cancers are adenocarcinomas (cancers that begin in cells that make and release mucus and other fluids). There are estimated 103, 170 (colon); 40, 290 (rectal) new cases and 51, 690 (colon and rectal combined) deaths from colon cancer in us in 2012. Screening with colonoscopy started at age of 50. ...Read more

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What is colon cancer?

Cancers: Cancers are abnormal, rapidly growing cells that do not know when to stop growing. These abnormal cells can damage local tissues, can attach to nearby organs or structures, can spread to lymph nodes, or can spread to other organs through the blood stream. Their growth damages what they are attached to, and often cancers encourage new blood flow to themselves. Cancer can grow in the colon. ...Read more

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Colon cancer any signs?

Colon cancer any signs?

Not always: Colon cancer tends to not have any signs or symptoms when it is early (when it is easiest to treat). That is why screening colonoscopies are so important, to remove any polyps that may become cancer, and to directly look for cancers. Colon cancer can cause bleeding from the rectum, tiredness from anemia, stool changes, or abdominal pain. Other things can cause this too. Best to be seen if ?S. ...Read more

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Does colon cancer hurt?

Does colon cancer hurt?

Usually not: Early stages of colon cancer often have no symptoms. Colon cancer has long developmental stages starting out as polyps and can take yrs to develop, hence screening colonoscopy is done every 10 yrs for normal folks. Polyps can be removed during colonoscopy. Advanced cancer can cause pain by obstructing bowel, spread to liver, bone, brain, lung etc. See doc regulalry. Good luck. ...Read more

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What cures colon cancer ?

What cures colon cancer
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Early detection!: The best thing that improves the chances of curing colon cancer is early detection. So preventive health care and screening are key. All adults should have a colonoscopy at age 50 to look for cancers or early cancers, usually as polyps. If you have a strong family history or certain conditions it is recommended you get earlier screening.Once detected, colon ca usually is cured by surgery, or drugs. ...Read more

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What causes colon cancer?

Very complicated: Monoclonal theory says that just like we are a living thing, we are born, we have jobs to do and then we die, each cell has a similar cycle of birth, life, and death. Cancer occurs when a cell develops so many mutations that it does not follow that cycle and does not die but can still divide itself and hides from our immune system which is there to detect abnormal cells and destroy them. ...Read more

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Can this be colon cancer?

Can this be colon cancer?

Not enough info: Colon cancer can present with or without symptoms. Common symptoms include change in stool caliber/consistency, rectal bleeding or blood with bm, abdominal pain, anemia. If you have not been screened, you should consider the various screening options for colon cancer, includine a stool test to check for blood, colonoscopy, or sigmoidoscopy. If you are having bleeding, you need a colonoscopy. ...Read more

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How does colon cancer begin?

Polyps.: Polyps (adenomas) are small, benign masses that can form within the colon. The life cycle of the mucus membranes of the colon becomes disrupted, either from genetic or environmental reasons, causing growth of polyps. If polyp growth continues abnormally, they have the potential to develop into an invasive lesion and become cancerous. ...Read more

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How does colon cancer spread?

How does colon cancer spread?

Lymph nodes: Lymph nodes are the way colon cancer cells usually escape the colon. It can grow through the colon into the surroundings. Finally it can move from lymph nodes into the blood stream that flows to the liver. When the colon is examined, and if lymph nodes are involved, chemotherapy is recommended. ...Read more

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How to know if colon cancer ?

Get tested: There are many tests that have been developed to test either a patient with concerning symptoms or just as a routine screening exam in an a symptomatic patient. Each individual situation is different. Testing stool for blood or now genetic abnormalities, rectal exam, X-rays such as barium enema or ct scan virtual colonoscopy are examples. Best is colonoscopy as you can both look and do. ...Read more

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Is colon cancer fast-growing?

Can be: The fastest-growers are the ones that follow genetic pathways associated with the lynch loci. They may not even be preceded by a polyp -- colonoscopy can be clean one year, and a year later, there's a cancer. That's actually quite fast as cancers go. Hope this helps. ...Read more

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How is colon cancer inherited?

Genes: Most colon cancers are not inherited. However, there is a subset which is associated with inherited genetic abnormalities such as hereditary polyposis a this hereditary non polyposis gene (hnpp). There are also syndromes that make you susceptible to a variety of different cancers including colon cancer such as lynch syndrome. ...Read more

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Can children get colon cancer?

Can children get colon cancer?

Yes: Usually adult children. The youngest patient I have seen in my practice with a family history of colon cancer, was first diagnosed at age 18. ...Read more

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39 old enough for colon cancer?

Yes: But not that common unless you have increased inherited risk factors. ...Read more

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What is terminal Colon cancer ?

What is terminal
Colon cancer ?

Stage IV: When the cancer has metastasized to other organs and there is no controlling it by medical or surgical means ...Read more

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Dr. Ihab Ibrahim
13 doctors shared insights

Colon (Definition)

The colon is another term for the large intestine. This is the final portion of the digestive system, responsible for absorbing water and storing stool before evacuation. It is divided into sections described as cecum; ascending, transverse, descending and ...Read more


Dr. M. Hytham Beck
12 doctors shared insights

Colonic (Definition)

This is a combining term referring to some condition, treatment or disease of the colon. Such as colonic enema, colonic ...Read more