Doctor insights on:
Familial Adenomatous Polyposis In Children
Autosomal dominant: Enter omim in your browser and go to the database of all inherited diseases. Autosomal dominant means that affected individuals have one normal and one abnormal gene copy, the abnormal one dominating to cause disease. An affected person has a 50% chance to pass on the abnormal gene and fap with each pregnancy. ...Read more
Autosomal Dominant: Fap is inherited in an autosomal dominant fashion. This means that if one parent has the gene, and the other parent doesn't, each child has a 50% chance of receiving the gene for fap. The disease causes hundreds of polyps to form in the colon (see the picture), leading to colon cancer. ...Read more
R/O colon cancer etc: Fap is an autosomal dominant --presented with 100's adenomatous colorectal polyps. In the classic fap- the risk for colorectal cancer is 100% by the time you reach 45Y.O. In adidition, there is also increased risk for duodenal, stomach, thyroid, CNS cancer.Colectomy is recommended to reduce your risk. Upper endoscopy is also recommended. You should see a surgeon re-colectomy-and genetic counsellor. ...Read more
Hereditary condition: Hereditary condition characterized by multiple polyps in colon which are neoplastic and have the potential for malignancy. ...Read more
It can: Also impact on other parts of the GI tract including the duodenum. This inherited disorder also is associated with abdominal desmoid tumors. ...Read more
I'm having constipation, could it be familial adenomatous polyposis and what are the other symptoms?
I had a colonoscopy at 18 due to pain, bleeding they found four polyps, one being a fap (familial adenomatous polyposis) why only one? More in future?
What is hereditary non-polyposis colorectal cancer (hnpcc) vs familial adenomatous polyposis (fap)?
Both inherited: In fap presents as colonic polyps (gardners syn will have other tumors), autosomal recessive due to mutations in gate keeper, tumor suppres gene. On the contrary hnpcc or lynch syndrome. Is autosomal dominant, due to dna mismatch in repair, associated with other cancers of stomach, endomet. Ca, ovary, brain, skin etc. ...Read more
FAP IS AN INHERITED: Condition in which numerous polyps form throughout the bowel. If you have a few, they can be endoscopically remomed. However, with time they become too numerous to treat this way individually. To prevent cancer, surgery is indicated, usually late teens to early 20's. But remember, these polyps can reccur throughout your stomach, snall and large bowels so close surveillance is definitely a must. ...Read more
Maybe: Not necessarily. Depend on liavtiim and symptoms. Observation may be ok depending on location. ...Read more
Benign growth: It is an increase of number of cells/ benign growth that originates from the glands-with mild abnormality of the cells (atypia). Atypia can be caused by other things like irritations /infection/inflammation- not just premalignancy. Discuss further with your doctor. ...Read more
Benign: Technically, it can be benign or malignant, so it has to be surgically removed and histologically examined for malignant criteria. If the pathology report comes back as hurthle cell adenoma, it's being considered as benign because there weren't any features that suggested a malignant hurthle cell carcinoma. ...Read more