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Doctor insights on: False Positive Lyme Disease Test

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I got a Lyme disease test done.& IgG 66 came positive out of the other 10 bands. What does this mean? Do I have Lyme or had it? Should i worry? Thanks

I got a Lyme disease test done.& IgG 66 came positive out of the other 10 bands. What does this mean? Do I have Lyme or had it? Should i worry? Thanks

Not enough info: This test is not evidence of lyme but also not proof you don't have it! ultimately lyme is a clinical diagnosis. 20-30% of those who have it never have a positive western blot. It's really important that the test include the 31 & 34 bands & most labs don't check it- igenex is the best lab for a thorough test. See a doc who uses igenex as that is someone able to make a proper diagnosis.See comment:. ...Read more

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Dr. Randy Baker
639 doctors shared insights

Lyme Disease (Definition)

A condition caused by borrelia burgdorferi. Acute symptoms can include bullseye rash, headaches, joint pain, fever, and flu-like sx. Chronic symptoms can include fibromyalgia symptoms, nerve pain in extremities, mood swings, brain fog, heart problems. Lab diagnoses are not very reliable, and sometimes clinical ...Read more


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What to do if i did a Lyme disease test and it showed IgG p58 ab. Positive a can you explain what that means?

Nothing by itself: A single positive IgG band means nothing. Was the screen positive? How many other IgG and IgM bands were positive? You should discuss all of this with the doctor who ordered the test. ...Read more

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Is there a Lyme disease test?

Is there a Lyme disease test?

Yes: There are blood and cerbrospinal fluid tests that can be done to aid in the diagnosis of lyme disease. They must be interpreted carefully by experienced clinicians. ...Read more

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Is it possible for a negative Lyme disease test to be wrong? I read online it's correct maybe 60% of the time....

Is it possible for a negative Lyme disease test to be wrong? I read online it's correct maybe 60% of the time....

About lab tests...: If a person does a lab test that is correct 60% of the time, that may mean the test result is incorrect 40% of the time. If a patient's symptoms and history are suggestive of Lyme disease, a Lyme disease positive test result will be more likely to be a true positive. If symptoms and history are NOT suggestive of Lyme disease, a positive test result has higher chances of being a false positive. ...Read more

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What is the best Lyme disease test? I've had the basic blood test done, came back negative, but is there a more thorough test to rule it out?

What is the best Lyme disease test? I've had the  basic blood test done, came back negative, but is there a more thorough test to rule it out?

Thorough WesternBlot: The screen many doctors use, the elisa, only detects about half of those with lyme. A much more sensitive and specific test is the western blot, but i strongly advise doing this through ignenex in palo alto, a specialty lab, as the test offered by most other labs does not include tests for antibodies to the 31 & 34 kda antigens, which are the most specific antigens for lyme! please see my comment. ...Read more

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If I have a negative lyme disease test, but antibiotics appear to be addressing my symptoms, is there any way to tell what caused the symptoms?

If I have a negative lyme disease test, but antibiotics appear to be addressing my symptoms, is there any way to tell what caused the symptoms?

Not a clue: When you submit a question, you must provide enough background information for site docs to review.You provide no info beyond a negative test result.No history, no exam findings,no initial problem. This is not a chat room, so any question must be complete,We do not have access to any previous question or data you upload. ...Read more

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Can a positive Lyme disease western blot strip test be mistaken for another disease?

Can a positive Lyme disease western blot strip test be mistaken for another disease?

Yes!: No lab test is perfect, including the westen blot for lyme. There is an approximately 4% chance of a positive being a "false positive" test. There is also an approximately 20% chance of false negatives, someone with lyme not having a positive western blot. This is why lyme is ultimately a clinical diagnosis, with labs used to support a diagnosis. Other tests may also be useful. Please see comment:. ...Read more

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How can someone test positive for two Lyme-specific bands on western blot and NOT have been exposed to Lyme disease? What is magic about 5 bands?

How can someone test positive for two Lyme-specific bands on western blot and NOT have been exposed to Lyme disease?  What is magic about 5 bands?

Immune complexities: Lyme disease is caused by a certain type of bacteria called a 'spirochete'- they are a whole class actually of bacteria and believe it or not can be found commonly in the mouth or elsewhere in the environment. You have to reach a certain 'threshold' with Lyme testing because there could be some cross-reactivity coming from these other types of bacteria. The immune system is extraordinarily complex ...Read more

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Tested positive for Lyme disease IgM but my western blot test came back negtive?

Tested positive for Lyme disease IgM but my western blot test came back negtive?

Then it's not Lyme: Lyme disease can be tricky -and you want to make sure you see someone like an Infectious Diseases doctor who knows how to treat it. The diagnosis is actually based on clinical findings, and the lab testing is generally 'supportive'. Since you're Western blot is negative, then it's very unlikely you have Lyme. There are other diseases that could cause 'Lyme-like' symptoms -and good to get evaluated ...Read more