Doctor insights on:
False Negative Lupus
What is the likelihood of a false negative herpes type specific blood test with background of lupus (sle)?
About 0% to 9%: Quest diagnostics' website states that their herpes type-specific IgG antibody test is 91-100% sensitive, so there are a few false negative results. A repeat test can be done 4-6 weeks later, if worried about a false negative. Lupus should not affect the result, but if a person is on strong immuno-suppressive therapy, his antibody production may be blocked, which may make test results unreliable. ...Read moreSee 1 more doctor answer
I recently had a positive ANA test. My dr tested folupus but it was negative. I have all the symptoms except rash. Can u have a false neg lupus test?
Keep working: Lupus is defined by a series of criteria, of which a strongly positive ANA is one. No specific test turning out negative rules out lupus. Perhaps you were tested for anti-smith(sm), which if positive hands us the diagnosis but is only positive in 1 of 3 patients. Perhaps there is a misunderstanding or you can request consultation. Lupus requires great courage -- will be thinking of you. ...Read moreSee 1 more doctor answer
Probably not lupus: Many people have symptoms suggestive of lupus but most turn out not to have the disease. The ANA and other blood tests are virtually always positive in patients with lupus. Negative tests mean you're not likely to have lupus. A bigger problem is false positive anas, in which case the teat is positive but the patient does not meed other diagnostic criteria to lupus. ...Read more
Need further test: False positive RPR may suggest antibodies in the blood that is cross reacting with RPR test reagent. Common antibodies are antiphospholipid antibodies that gives false positive RPR. Lupus is diagnosed based on signs and symptoms PLUS presence of ANA antibodies in the blood. You can ask your MD to check for these antibodies by blood tests. ...Read moreSee 2 more doctor answers
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