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Doctor insights on: False Negative Biopsy For Celiac

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My endoscopy biopsy looked exactly like something caused by Celiac disease but my blood test came back negative, what else could it be?

My endoscopy biopsy looked exactly like something caused by Celiac disease but my blood test came back negative, what else could it be?

Biopsy definitive.: In regards to celiac disease, the biopsy is more diagnostically reliable than the blood test, so if the blood test showed typical evidence of celiac disease, I'd believe it. ...Read more

Dr. Barbara Lavi
2 doctors shared insights

Biopsy (Definition)

Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more


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Is it possible to have celiac disease if you have positive biopsy yet negative DQ2/DQ8? I have fasciculations and they stop when i don't eat gluten.

Is it possible to have celiac disease if you have positive biopsy yet negative DQ2/DQ8? I have fasciculations and they stop when i don't eat gluten.

Yes: Biopsy is the gold standard and your history is totally compatible with gluten intolerance. If gluten bothers you, you need to avoid it regardless of the test results. The above are just genetic markers and many people with these markets do not have gluten intolerance at all. ...Read more

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I had a biopsy of my small intestine come back with elevated lymphocytes and all the blood came back negative for celiac disease. What r other reasons?

I had a biopsy of my small intestine come back with elevated lymphocytes and all the blood came back negative for celiac disease. What r other reasons?

Need more info: The hall mark of celiac disease is destruction of the lining of the intestine (mucosal atrophy). To give you a better idea about what is going on i would need a complete report of the biopsy and description of your symptoms. ...Read more

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Can endoscopy and biopsy to diagnose positive celiac disease be wrong? Are there other conditions that damage celia like that?

Can endoscopy and biopsy to diagnose positive celiac disease be wrong? Are there other conditions that damage celia like that?

Celiac disease: Lab tests (ttg antibody) should generally be used to confirm celiac disease, along with biopsy results. The characteristic appearance of celiac disease on biopsies can occasionally be caused by other small bowel conditions. ...Read more

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If immunosuppressed patient & have symptoms of celiac disease, how to confirm it? Especially they will have -ve IgA ttg test and almost normal biopsy!

If immunosuppressed patient & have symptoms of celiac disease, how to confirm it? Especially they will have -ve IgA ttg test and almost normal biopsy!

Clinical challenge: If none of the blood tests are conclusive, biopsy is generally diagnostic. If for any reason even that is not helpful, it may be worthwhile to do a clinical trial, i.E, put the patient on gluten free diet for at least 3 months to see if there is any improvement. If there is improvement it may be challenged by re-exposing to gluten. ...Read more

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Can the duodenum appear normal visually but have biopsies come back positive for celiac disease?

Yes...: Celiac disease is often "patchy", so that multiple biopsies (four to six) at various duodenal sites are needed to accurately identify the entity. As such, some parts of the duodenum may visually appear relatively unremarkable. Also, gluten avoidance may result in a normalized small bowel lining prior to diagnostic biopsies. ...Read more

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Is it absolutely impossible to have celiac disease without positive blood tests and biopsy? Even with all symptoms and other autoimmune diseases?

Very unlikely: The gold standard of celiac disease is the small bowel biopsy. Blood tests, if positive are helpful. You don't provide enough clinical detail to give you more specific advice. Denmark has several excellent hospitals and medical schools.I suggest you should be evaluated in a tertiary medical center.l ...Read more

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If I ? celiacs and had EGD and colonoscopy (for different reason) with (-)biopsy for celiacs, is there any benefit to having blood test 3 yr later?

If I ? celiacs and had EGD and colonoscopy (for different reason) with (-)biopsy for celiacs, is there any benefit to having blood test 3 yr later?

Depends: If you were on a gluten free diet at the time of egd then the sensitivity of biopsies will be lower. In this case doing the blood test may be reasonable. Please feel free to contact me if you have more questions on this. ...Read more

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I tested positive for celiac disease through a blood test but waiting to get my biopsy done, but liver & spleen are enlarged can it be cancer?

I tested positive for celiac disease through a blood test but waiting to get my biopsy done, but liver & spleen are enlarged can it be cancer?

Organomegaly: Celiac disease is not usually associated with enlargement of liver and spleen. While some leukemias/lymphomas might cause this, they are not common in your age group, and might be associated with abnormalities of CBC or other tests. If you have solid anti-gliadin antibody test, then a small bowel biopsy is probably not essential. Fatty liver, cirrhosis, circulatory issues might be worth excluding. ...Read more

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I have a question my daughter was diagnosed with celiac disease about 8 weeks ago. She is 19 years old. Her symptoms then were vomiting diarrhea and severe stomach pain. The biopsies came back positive for Celiac. She has removed any gluten from her diet

I have a question my daughter was diagnosed with celiac disease about 8 weeks ago. She is 19 years old. Her symptoms then were vomiting diarrhea and severe stomach pain. The biopsies came back positive for Celiac. She has removed any gluten from her diet

Please start over: your question if you actually asked one did not make it to the site. You provided good background, but could shorten it in a future submission.Just say recently diagnosed celiac (biopsy positive).Need to know ??????? If you don't ask a clear question we cannot be much help.This is not a chat room.Your questions are never linked & we cannot see uploads.Please start over. ...Read more

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I got diagnosed for celiac disease but my test came out false negative. My primary dr said I have it.I didn't eat gluten for 6months when I took this

I got diagnosed for celiac disease but my test came out false negative. My primary dr said I have it.I didn't eat gluten for 6months when I took this

Depends on the test: The serum tests are pretty good (even off glut), not perfect. Was intestinal biopsy examined? I'm interested to know why your primary doc says you have it. I suspect you have a clear/obvious change in symptoms depending on good trials on and off gluten. Gluten intolerance, unrelated to celiac disease and to food allergy, exists as a separate phenomenon. Recommend continued avoidance if true ...Read more

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I live in india.I have lymphoplasmacytic infiltrate in lamina propria shown in biopsy. What does it mean, what are it's causes?(celiac test negative)

Insufficient info: The biopsy results you provided suggest chronic inflammation but do not point to a specific diagnosis. You apparently have consulted a GI specialist and that doctor and the pathologist who read the biopsy are in the best position to advise you. This forum may not be of much help in assisting you. Wish you a speedy recovery and good health! ...Read more

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Can I have celiac if the blood and gene tests were positive, but biopsy was negative?

Can I have celiac if the blood and gene tests were positive, but biopsy was negative?

Yes, you can: Celiac disease often presents in the small bowel as "patchy" so biopsies of only one area may not be representative. Also, if you have celiac disease but eliminated gluten long enough for classic villous blunting changes in the small bowel to have resolved, then biopsies will look normal & the disease may be missed. Talk to your doctor about definitive diagnostic criteria for your piece-of-mind. ...Read more

Dr. John Chiu
620 doctors shared insights

Celiac Disease (Definition)

An immune reaction to eating gluten, a protein found in ...Read more