Doctor insights on:
False Negative Biopsy For Celiac
My endoscopy biopsy looked exactly like something caused by Celiac disease but my blood test came back negative, what else could it be?
Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more
Is it possible to have celiac disease if you have positive biopsy yet negative DQ2/DQ8? I have fasciculations and they stop when i don't eat gluten.
Yes: Biopsy is the gold standard and your history is totally compatible with gluten intolerance. If gluten bothers you, you need to avoid it regardless of the test results. The above are just genetic markers and many people with these markets do not have gluten intolerance at all. ...Read moreSee 1 more doctor answer
After an endoscopy and colonoscopy dr said he found scalloping that looked like celiac disease. Biopsy was negative. Should i go gluten free?
Celiac disease? Biopsy needed?Endomysial AB IGA Negative,Gliadin AB IGA High=16, Anti-Gliadin IGG A B High=22, t-transglutanimaze IGG Normal 1.7, t-transglutanimaze igA Normal 3.1, IGA Normal 186
I had a biopsy of my small intestine come back with elevated lymphocytes and all the blood came back negative for celiac disease. What r other reasons?
Can endoscopy and biopsy to diagnose positive celiac disease be wrong? Are there other conditions that damage celia like that?
Yes...: Celiac disease is often "patchy", so that multiple biopsies (four to six) at various duodenal sites are needed to accurately identify the entity. As such, some parts of the duodenum may visually appear relatively unremarkable. Also, gluten avoidance may result in a normalized small bowel lining prior to diagnostic biopsies. ...Read more
If immunosuppressed patient & have symptoms of celiac disease, how to confirm it? Especially they will have -ve IgA ttg test and almost normal biopsy!
Clinical challenge: If none of the blood tests are conclusive, biopsy is generally diagnostic. If for any reason even that is not helpful, it may be worthwhile to do a clinical trial, i.E, put the patient on gluten free diet for at least 3 months to see if there is any improvement. If there is improvement it may be challenged by re-exposing to gluten. ...Read more
I was diagnosed many ago with IBS & three years ago after a biopsy have celiac disease. I have been on a strict g.F diet but still have IBS constapatn?
Is it absolutely impossible to have celiac disease without positive blood tests and biopsy? Even with all symptoms and other autoimmune diseases?
Very unlikely: The gold standard of celiac disease is the small bowel biopsy. Blood tests, if positive are helpful. You don't provide enough clinical detail to give you more specific advice. Denmark has several excellent hospitals and medical schools.I suggest you should be evaluated in a tertiary medical center.l ...Read more
In celiac disease, the body reacts to gluten (in wheat and gluten-like proteins in rye and barley) resulting in damage to the small intestine. This limits the intestine's ability to absorb some nutrients. Typically, people with celiac disease have loose stools, bloating, abdominal pain or discomfort, weight loss, poor weight gain ...Read more
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