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Doctor insights on: False Negative Biopsy For Celiac

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My endoscopy biopsy looked exactly like something caused by Celiac disease but my blood test came back negative, what else could it be?

My endoscopy biopsy looked exactly like something caused by Celiac disease but my blood test came back negative, what else could it be?

Biopsy definitive.: In regards to celiac disease, the biopsy is more diagnostically reliable than the blood test, so if the blood test showed typical evidence of celiac disease, I'd believe it. ...Read more

Dr. Lynne Weixel
2 doctors shared insights

Biopsy (Definition)

Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more


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Is it possible to have celiac disease if you have positive biopsy yet negative DQ2/DQ8? I have fasciculations and they stop when i don't eat gluten.

Is it possible to have celiac disease if you have positive biopsy yet negative DQ2/DQ8? I have fasciculations and they stop when i don't eat gluten.

Yes: Biopsy is the gold standard and your history is totally compatible with gluten intolerance. If gluten bothers you, you need to avoid it regardless of the test results. The above are just genetic markers and many people with these markets do not have gluten intolerance at all. ...Read more

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I had a biopsy of my small intestine come back with elevated lymphocytes and all the blood came back negative for celiac disease. What r other reasons?

I had a biopsy of my small intestine come back with elevated lymphocytes and all the blood came back negative for celiac disease. What r other reasons?

Need more info: The hall mark of celiac disease is destruction of the lining of the intestine (mucosal atrophy). To give you a better idea about what is going on i would need a complete report of the biopsy and description of your symptoms. ...Read more

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Can endoscopy and biopsy to diagnose positive celiac disease be wrong? Are there other conditions that damage celia like that?

Can endoscopy and biopsy to diagnose positive celiac disease be wrong? Are there other conditions that damage celia like that?

Celiac disease: Lab tests (ttg antibody) should generally be used to confirm celiac disease, along with biopsy results. The characteristic appearance of celiac disease on biopsies can occasionally be caused by other small bowel conditions. ...Read more

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Can the duodenum appear normal visually but have biopsies come back positive for celiac disease?

Yes...: Celiac disease is often "patchy", so that multiple biopsies (four to six) at various duodenal sites are needed to accurately identify the entity. As such, some parts of the duodenum may visually appear relatively unremarkable. Also, gluten avoidance may result in a normalized small bowel lining prior to diagnostic biopsies. ...Read more

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If immunosuppressed patient & have symptoms of celiac disease, how to confirm it? Especially they will have -ve IgA ttg test and almost normal biopsy!

If immunosuppressed patient & have symptoms of celiac disease, how to confirm it? Especially they will have -ve IgA ttg test and almost normal biopsy!

Clinical challenge: If none of the blood tests are conclusive, biopsy is generally diagnostic. If for any reason even that is not helpful, it may be worthwhile to do a clinical trial, i.E, put the patient on gluten free diet for at least 3 months to see if there is any improvement. If there is improvement it may be challenged by re-exposing to gluten. ...Read more

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Is it absolutely impossible to have celiac disease without positive blood tests and biopsy? Even with all symptoms and other autoimmune diseases?

Very unlikely: The gold standard of celiac disease is the small bowel biopsy. Blood tests, if positive are helpful. You don't provide enough clinical detail to give you more specific advice. Denmark has several excellent hospitals and medical schools.I suggest you should be evaluated in a tertiary medical center.l ...Read more

Dr. John Chiu
606 doctors shared insights

Celiac Disease (Definition)

In celiac disease, the body reacts to gluten (in wheat and gluten-like proteins in rye and barley) resulting in damage to the small intestine. This limits the intestine's ability to absorb some nutrients. Typically, people with celiac disease have loose stools, bloating, abdominal pain or discomfort, weight loss, poor weight gain ...Read more