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Doctor insights on: Factor Xiii Activity

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Factor viii inhibitor in hemophilia? What is a factor viii inhibitor?

Factor viii inhibitor in hemophilia? What is a factor viii inhibitor?

Antibody to factor: Viii protein. People who are deficient in factor viii, i.e., have severe hemophilia, are treated with infusion of factor viii. Some make antibodies to factor viii and inhibit its function and are called factor viii inhibitors. Rarely non-hemophiliac can also develop such an inhibitor. ...Read more

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Should a person with factor xiii von willebrands disease thats pregnant go on bedrest?

Should a person with factor xiii von willebrands disease thats pregnant go on bedrest?

Not necessarily: There are many women who get pregnant and deliver their babies without ever knowing they even have von willebrand's disease (vwd). That being said, there are many types of VWD that differ greatly in their severity. If a person has a history of VWD and has had many issues because of it, bed rest could be warranted if advised by an ob/gyn. ...Read more

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Is leiden factor v genetic?

Is leiden factor v genetic?

Yes: Factor v leiden is a genetic condition. If you have one copy of a fvl mutation, you are heterozygous with an increased risk of blood clotting. If you have 2 copies you are homozygous with an even higher risk of clotting. The inheritence pattern is simple mendelian genetics. You get one copy of the gene from your mother and one from your father. ...Read more

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What does a low von willebrand factor (vwf) ag: 33 %, low vwf activity: 29 % and factor viii activity: 52 % result mean?

What does a  low von willebrand factor (vwf) ag: 33 %, low vwf activity: 29 % and factor viii activity: 52 % result mean?

VWD: First of all, these test need to be repeated at least one more time, prederably while you are off all medications. If persistently low, this may mean that you have von willibrand disease (VWD) which is a bleeding disorder. These are several types of VWD and more testing is needed to determine the type. You need to see a hematologist for this. Avoid any surgery and trauma. ...Read more

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Is your risk for arthritis genetic or activity related?

Is your risk for arthritis genetic or activity related?

Both: The cause of autoimmune type arthritis such as rheumatoid arthritis is unknown but may occur when certain factors in the environment trigger the activation of the immune system to inappropriately attack the body's own tissues. There may be some genetic predisposition. Repetitive trauma, instability of joints, and fractures can lead to "wear and tear" osteoarthritis or post-traumatic arthritis. ...Read more

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How severe is factor v leiden (homozygous)?

How severe is factor v leiden (homozygous)?

Risk for blood clots: People homozygous for factor v leiden are about 50 times more at risk of developing blood clots in their veins and complications related to that. See this site for more info. http://www.mayoclinic.org/diseases-conditions/factor-v-leiden/basics/definition/con-20032637. ...Read more

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What is the disease factor v leiden?

What is the disease factor v leiden?

Blood clots: People with leiden variant of clotting factor v have tendency to form clots in blood vessels and develop thromboses in veins that cause pulmonary emboli. Women on birth control pills are more susceptible to clot formation if they have factor v leiden. ...Read more

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What does Acquired Coagulation Factor Deficiency mean relating to surgery?

What does Acquired Coagulation Factor Deficiency mean relating to surgery?

Higher risk of bleed: ... is a concern. A select factor deficiency (missing, depleted or inhibited for various reasons) can adversely impact at least 1 of 3 pathways that prevent bleeding. Some factor deficiencies are more serious than others. The surgeon usually consults a hematologist in these cases so that there are no problems during or around the surgery. No excess bleeding w/ any prior surgery = good omen. ...Read more

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What genes play an important role in stroke?

What genes play an important role in stroke?

Many: There is no "stroke gene". There are many conditions which are genetically determined, such leiden factor v deficiency which leads to stroke. If you have strong family history of stroke, you should find out what condition(s) your family has contributing to their strokes. This is a more productive approach than searching the human genome. ...Read more

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What genes play an important role in cerebrovascular disease?

What genes play an important role in cerebrovascular disease?

Many: Since there are many types of stroke, this is a very complicated question. Most strokes are related to atherosclerosis ( fat deposit in the arteries). So the genes involved ( there are many) in lipid (fat) metabolism and blood pressure regulation are important. One important set of genes seems to be located on chromosome number 9. In any case this is an active area of medical research. ...Read more

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What is leiden factor v?

What is leiden factor v?

Clotting abnormality: Factor v leiden is a genetic mutation in one of the blood's clotting proteins. People with this mutation are at higher risk of forming blood clots. ...Read more

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What genes play an important role in coronary vascular (artery) disease?

What genes play an important role in coronary vascular (artery) disease?

Genes play a role: Researchers are currently trying to identify genes that increase one's risk for getting artery disease and heart attacks. By looking at families who have several generations with such diseases, researchers have found certain genes are involved. Some genes cause cholesterol levels to stay high. The challenge now is to figure out how each of the identified genes leads to artery disease and blockage. ...Read more

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What is factor v leiden syndrome?

What is factor v leiden syndrome?

Thrombosis: People who inherit the leiden variant of coagulation factor v are at incresed risk of venous thrombosis. Those who are heterozygotes their risk is 5-10 fold higher, homozygotes are about 50 fold greater risk. Women on birth contol pills are partiuclarly susceptible to thrombosis if they have leiden factor v. If the affected individual develops thromobsis, life long anti-coagulation may be needed. ...Read more

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How does the deficiency of factor xiii result in prolong ptt but bleeding risk is not appreciable?

How does the deficiency of factor xiii result in prolong ptt but bleeding risk is not appreciable?

Mild Hemophilia: Sounds like mild hemophilia. Most patients usually have problems with bleeding only after serious injury, trauma or surgery. In many cases, mild hemophilia is not diagnosed until an injury, surgery or tooth extraction results in prolonged bleeding. I would not recommend surgery, including dental surgery without consulting with your hematologist. We premedicate most patients like you with ddavp (desmopressin). ...Read more

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What factor will age play in concussion risk?

What factor will age play in concussion risk?

Kids are more prone : Younger children (under 10) are more susceptible to concussion and may take longer to recover. If a concussion is suspected in a child an evaluation by a doctor should be performed asap and they should be taken out of any sport or strenuous activity for the remainder of that day. There should be no return until completely symptom free and cleared by a doctor. ...Read more

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Is factor 7 gene mutation (heterozygote) thrombophila?

No: Factor 7 mutation is very rare and causes increased risk of bleeding (not being able to clot). Factor 5 deficiency is the most common form of thrombophilia (increased risk of abnormal clotting). ...Read more