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Doctor insights on: Factor Xa Inhibitor Anti Coagulation Agent

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Factor viii inhibitor in hemophilia? What is a factor viii inhibitor?

Factor viii inhibitor in hemophilia? What is a factor viii inhibitor?

Antibody to factor: Viii protein. People who are deficient in factor viii, i.e., have severe hemophilia, are treated with infusion of factor viii. Some make antibodies to factor viii and inhibit its function and are called factor viii inhibitors. Rarely non-hemophiliac can also develop such an inhibitor. ...Read more

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Azd 6244- mek inhibitor- a selective mitogen-activated protein kinase (mek) inhibitor. Mk 2206- akt inhibitor. Why prescription for me? It ? Nsclc/mets

Azd 6244- mek inhibitor- a selective mitogen-activated protein kinase (mek) inhibitor.    Mk 2206-  akt inhibitor.  Why  prescription for me? It ? Nsclc/mets

Molecular targeting: These agents are designed to selectively knock out key pathways your tumor may use to grow. Presumably you already had your tumor tested for these different mutations. Ask the doctor offering these options to explain their rationale. These are investigational studies and many of the treatment costs may be covered-ask. ...Read more

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What is factor five leiden lovenox (enoxaparin) used to treat?

What is factor five leiden lovenox (enoxaparin) used to treat?

Tendency to clot: Factor v leiden is a hereditary abnormality of a clotting protein that increases your risk of forming clots, notably in the veins (phlebitis). If you are undergoing a procedure that would also increase this risk (surgery, prolonged immobilization), Lovenox (enoxaparin) might be used preventively. It is only for short-term use, and oral drugs such as warfarin would be used if you need long-term protection. ...Read more

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I'm in AF also CAD. Now taking pradaxa, may be change into plasmin (anti-coagulant drugs from china, Lumbrokinase)?

I'm in AF also CAD. Now taking pradaxa, may be change into plasmin (anti-coagulant drugs from china, Lumbrokinase)?

Pradaxa vs lumbrokin: I would NOT recommend this - while Pradaxa is costly - it comes with the approval of the FDA along with extensive testing for efficacy and safety. From my research Lumbrokinase is derived from earthworms and is still considered investigational. I would be leery of any medications obtained from off shore (NO I do NO work for big Pharma) their safety and efficacy are unproven. ...Read more

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Is buproprion a monoamine oxidase inhibitor (maoi) type of drug?

Is buproprion a monoamine oxidase inhibitor (maoi) type of drug?

No: Bupropion (wellbutrin) inhibits re-uptake of norepinephrine and Dopamine into neurons (nerve and brain cells). It does not inhibit mao, so there are no dietary restrictions or common medication interactions, unlike the the maois. ...Read more

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Explain ACE inhibitor use as a anti hypertensive?

Explain ACE inhibitor use as a anti hypertensive?

Relaxes vasc muscle: Angiotensin i is a hormone that is converted to angiotensin ii with the help of the angiotensin converting enzyme (ace). Angiotensin ii is a very powerful constrictor of vascular muscle and in doing so increases the pressure inside the vessels (the blood pressure). If you inhibit (or neutralize) the ace then you don't produce as much angiotensin ii and the BP does not increase. ...Read more

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Could anti uricosuric agents also prevent heart /coronary arteries disease/s?

Could anti uricosuric agents also prevent heart /coronary arteries disease/s?

No: Gout is just a marker for increased heart risk. Lowering uric acid levels has never been shown to reduce the risk of heart disease. ...Read more

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Is baby aspirin used for anti inflammatory?

Is baby aspirin used for anti inflammatory?

Not really: Aspirin at low doses has the ability to decrease the stickiness of your platelets and is often used to reduce chances of a stroke or heart attack. Aspirin does have anti-inflammatory properties, but its association with liver damage/failure and brain damage in kids (reye syndrome) led to rare use under the age of 16. ...Read more

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What is a recombinant clotting factor product?

What is a recombinant clotting factor product?

Ultra High Tech!: These products(which are used to treat a wide variety of bleeding disorders like hemophilia, and von willebrand's disease) are made either by being completely free of human plasma derivative; or use a pasteurized form that is very safe. These products are not without there share of risks; and can potentially cause diseases as well. They are also very, very expensive so let the buyer beware! ...Read more

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Was taking a recombinant-derived fviii for hempohilia a and inhibitor appear. Finishing iti and doc says 2 try plasma fviii. Alphanate (factor viii and von willebrand factor) or koate and y?

Follow his advice: Development of recombinant factor v111 inhibitor those occur frequently after prolonged treatment and those make the treatment less effective. Hence your dr will recommend products to bypass the inhibition. ...Read more

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Are any of the new anticoags useful for factor v leiden and lupus anticoag. Antibody. On lovenox (enoxaparin) 100mg bid. Venous and arterial clotting and pes. ?

Are  any of the new anticoags useful for factor v leiden and lupus anticoag. Antibody. On lovenox (enoxaparin) 100mg bid. Venous and arterial clotting and pes. ?

Maybe: The newer medications to prevent blood clots are not approved for use in the us for your condition. There is published research in europe showing that these medications can be used effectively for your type of problem. My personal bias is that you should wait until more research has been done. Your doctor can help advise you as to the status of this research as it evolves. ...Read more

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Could Coumadin (warfarin) effect blood platelet count?

Could Coumadin (warfarin) effect blood platelet count?

Usually not: Because warfarin is a vitamin k antagonist and affect production of proteins needed for blood clotting, whereas platelets are product of blood cells. ...Read more

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Is xarelta as effective in treating blood clots as warfarin?

Is xarelta as effective in treating blood clots as warfarin?

Xarelto: Yes. Xarelto (rivaroxaban) is equally effective as coumadin( warfarin). Initially it was given only for irregular heart beat atrial fibrillation. Now the use is expanded to leg clot DVT and lung clot pe. The advantage of xarelto over Coumadin is that there is no periodic blood checkup for pt/ inr just like coumadin. It can be expensive & inconvenient. Can't monitor level & no antidote. ...Read more

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I'm wondering why are anticoagulants lesser effective than anti-platelet aggregation drugs in arteries?

Anticoagulants: Complicated answer, there are different mechanisms for arterial vs venous clotting. Platelets more critical for arterial clotting. ...Read more

Dr. Jesus Yap Dr. Yap
2 doctors agreed:
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For recurrent stroke prevention, which is best: ASA vs Plavix (clopidogrel) vs ASA/Plavix (clopidogrel) vs Aggrenox? Risk of bleeding worse with any particular?

Dr. Jesus Yap Dr. Yap
2 doctors agreed:
For recurrent stroke prevention, which is best: ASA vs Plavix (clopidogrel) vs ASA/Plavix (clopidogrel)  vs Aggrenox? Risk of bleeding worse with any particular?

Aggrenox: Aggrenox probably best for recurrent stroke followed closely by ASA. Risk of bleeding is highest with ASA/Plavix combination least with Aggrenox ...Read more

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How effective is pradaxa dabigatran as an alternative to coumadin (warfarin)?

How effective is pradaxa dabigatran as an alternative to coumadin (warfarin)?

Pretty good, but...: They are essentially equivalent in thinning the blood to replace coumadin (warfarin), (warfarin) but they require twice daily dosing. Yes, you don't have to get your blood tested like you do with coumadin (warfarin), (warfarin) but if you have a bad bleed, there is no antidote for either you mentioned, like there is for coumadin (warfarin). So one must weigh the risks vs. The benefits, as we do everyday in medicine. ...Read more

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Does clopidogrel reduces the platelet count?

Does clopidogrel reduces the platelet count?

Not typically: It is not the mechanism of action. Ttp is among rare but potentially serious adverse reactions which is associated with drop in platelet count. ...Read more