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Doctor insights on: Factor Viii Deficiency

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Dr. Abraham Jaskiel
26 doctors shared insights

Factor Viii Deficiency (Overview)

Factor VIII deficiency (also known as Hemophilia A) is disease of the blood in which a person lacks a protein necessary for clotting. These patients are prone to excessive bleeding from minor trauma.


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Factor viii inhibitor in hemophilia? What is a factor viii inhibitor?

Factor viii inhibitor in hemophilia? What is a factor viii inhibitor?

Antibody to factor: Viii protein. People who are deficient in factor viii, i.e., have severe hemophilia, are treated with infusion of factor viii. Some make antibodies to factor viii and inhibit its function and are called factor viii inhibitors. Rarely non-hemophiliac can also develop such an inhibitor. ...Read more

Dr. Abraham Jaskiel
26 doctors shared insights

Factor Viii Deficiency (Overview)

Factor VIII deficiency (also known as Hemophilia A) is disease of the blood in which a person lacks a protein necessary for clotting. These patients are prone to excessive bleeding from minor trauma.


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What sort of disorder is factor viii deficiency?

R/o vWD: A patient with von willebrand's disease, which is extremely common and usually mild, may be told they have factor viii deficiency. ...Read more

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Is leiden factor v genetic?

Is leiden factor v genetic?

Yes: Factor v leiden is a genetic condition. If you have one copy of a fvl mutation, you are heterozygous with an increased risk of blood clotting. If you have 2 copies you are homozygous with an even higher risk of clotting. The inheritence pattern is simple mendelian genetics. You get one copy of the gene from your mother and one from your father. ...Read more

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What sort of disorder is factor viii deficiency?

R/o vWD: A patient with von willebrand's disease, which is extremely common and usually mild, may be told they have factor viii deficiency. ...Read more

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Is factor 7 gene mutation (heterozygote) thrombophila?

Is factor 7 gene mutation (heterozygote) thrombophila?

No: Factor 7 mutation is very rare and causes increased risk of bleeding (not being able to clot). Factor 5 deficiency is the most common form of thrombophilia (increased risk of abnormal clotting). ...Read more

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What are the symptoms of factor viii deficiency?

What are the symptoms of factor viii deficiency?

Bleeding/bruising: Factor viii deficiency or hemophilia- is a bleeding disorder. It is hereditary in most cases . The symptoms would be spontaneous bleeding- either in the joints, skin/gum, or other places etc or prolonged bleeding. The severity of bleeding will depend on how low the level of the factor viii is.. Usually the bleeding episodes will manifest at early age. Discuss further with your hematologist. ...Read more

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How severe is factor v leiden (homozygous)?

How severe is factor v leiden (homozygous)?

Risk for blood clots: People homozygous for factor v leiden are about 50 times more at risk of developing blood clots in their veins and complications related to that. See this site for more info. http://www.mayoclinic.org/diseases-conditions/factor-v-leiden/basics/definition/con-20032637. ...Read more

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Is pyruvate dehydrogenase deficiency heritable?

Is pyruvate dehydrogenase deficiency heritable?

Yes.: In the most common situation it is inherited in an x-linked pattern, affecting hemizygous males (with one x chromosome) and heterozygous females (two x chromosomes, one with mutation). Less commonly it is inherited in an autosomal recessive pattern, in which a mutation must be provided by both the mother and the father of the affected person. ...Read more

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What's a factor deficiency?

What's a factor deficiency?

Clotting factor?: This typically refers to a deficiency of a clotting factor that may cause increased bleeding symptoms. ...Read more

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What is factor v leiden syndrome?

What is factor v leiden syndrome?

Thrombosis: People who inherit the leiden variant of coagulation factor v are at incresed risk of venous thrombosis. Those who are heterozygotes their risk is 5-10 fold higher, homozygotes are about 50 fold greater risk. Women on birth contol pills are partiuclarly susceptible to thrombosis if they have leiden factor v. If the affected individual develops thromobsis, life long anti-coagulation may be needed. ...Read more

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Anemia; is ethnicity a factor?

Sometimes: Anemia is sometimes much more likely is certain ethnicities. These anemias include sickle cell and thalassemia minor. ...Read more

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Is omega 3 deficiency and vitamin a deficiency genetic?

Is omega 3 deficiency and vitamin a deficiency genetic?

Vitamin deficiency: Not usually. Vitamin deficiencies are usually due to dietary deficiencies, but rarely can be related to problems absorbing nutrients. That may be due to a genetic defect. ...Read more

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What are the tests for factor viii deficiency?

What are the tests for factor viii deficiency?

Blood tests and: Family history. Blood tests for levels of factor viii are available, though simpler tests, e.g., PTT with appropriate family history may be sufficient. ...Read more

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What is the treatment for factor viii deficiency?

What is the treatment for factor viii deficiency?

Factor VIII: Concentrate. Factor viii is prepared by recombinant technology, though it may also be extracted from human plasma. Depending on the severity of deficiency, factor viii may be given prophylactically or to treat episodes of bleeding. The drug is given intravenously. ...Read more

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Can you tell me if someone is heterozygous w/ the hemophilia gene, is it possible for them to still have factor viii deficiency?

Yes, in men: Hemophilia is a sex linked disorder and men develop the disease when there only x chromosome has the defective gene. See this site for more info. http://www.nlm.nih.gov/medlineplus/ency/article/000538.htm. ...Read more

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Positive mthfr heterozygous after multiple miscarriages, known pernicious anemia, what is the likelihood of having other b vitamin deficiencies?

Positive mthfr heterozygous after multiple miscarriages, known pernicious anemia, what is the likelihood of having other b vitamin deficiencies?

Not more likely but: Pernicious anemia is due to problems absorbing B12 but doesn't interfere with absorbing other vits.Mthfr mutations mean you have trouble converting Folic Acid to the active form, so take l-5-mthf.Genes don't affect absorption of other b vits but due to genetics some require higher amounts of b's than others-your other issues don't mean you're more likely to have this but it's safe to try b complex. ...Read more

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What does Acquired Coagulation Factor Deficiency mean relating to surgery?

What does Acquired Coagulation Factor Deficiency mean relating to surgery?

Higher risk of bleed: ... is a concern. A select factor deficiency (missing, depleted or inhibited for various reasons) can adversely impact at least 1 of 3 pathways that prevent bleeding. Some factor deficiencies are more serious than others. The surgeon usually consults a hematologist in these cases so that there are no problems during or around the surgery. No excess bleeding w/ any prior surgery = good omen. ...Read more

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Why is blood clotting abnormal with vitamin K deficiency?

Why is blood clotting abnormal with vitamin K deficiency?

Clotting factors: Vitamin k is used to create several factors in the clotting cascade (the system that ends in a blood clot). If vitamin k isn't there, then those factors are deficient, and blood won't clot as well. This is why newborns get a vit k shot, to avoid something called "hemorrhagic disease of the newborn.". ...Read more

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