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Doctor insights on: Factor Viii

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Factor viii inhibitor in hemophilia? What is a factor viii inhibitor?

Factor viii inhibitor in hemophilia? What is a factor viii inhibitor?

Antibody to factor: Viii protein. People who are deficient in factor viii, i.e., have severe hemophilia, are treated with infusion of factor viii. Some make antibodies to factor viii and inhibit its function and are called factor viii inhibitors. Rarely non-hemophiliac can also develop such an inhibitor. ...Read more

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What are the functions of factor viii? What if you're low on your factor viii?

What are the functions of factor viii? What if you're low on your factor viii?

Blood clotting: Factor viii is a clotting factor. This is one of many that help you stop bleeding from a cut. If you are low on factor 8, then you will bleed longer than someone who has normal factor 8. The associated condition is called hemophilia a. Treatment is done by replacing the factor 8 when necessary, such as after a trauma or surgery. In severe cases, you may be given factor 8 regularly for prevention. ...Read more

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Why plasmapheresis is used to remove factor viii; could this be useful in a procoagulable state?

Why plasmapheresis is used to remove factor viii; could this be useful in a procoagulable state?

No.: Plasmapheresis removes all the clotting proteins, including factor viii, but the body rapidly replaces what is taken out. Usually all proteins are back to their usual levels within 24 hours. This would not be long enough to provide meaningful anti-coagulation. ...Read more

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What are the functions of factor viii? What if you're low on your factor viii?

Blood clotting: Factor viii is a clotting factor. This is one of many that help you stop bleeding from a cut. If you are low on factor 8, then you will bleed longer than someone who has normal factor 8. The associated condition is called hemophilia a. Treatment is done by replacing the factor 8 when necessary, such as after a trauma or surgery. In severe cases, you may be given factor 8 regularly for prevention. ...Read more

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What does it mean if I have a high factor viii assay value? E.G. 174%?

What does it mean if I have a high factor viii assay value? E.G. 174%?

Not hemophilia: Probably were being tested form blood clotting disorders. This is a test for hemophilia a (which you do not have based on this test). ...Read more

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What test can be done for someone with thrombophilia factor viii?

What test can be done for someone with thrombophilia factor viii?

Get exact diagnosis: Hemophilia with factor viii deficiency is the most common kind. These people today for the most part live near-normal lives thanks to biotechnology. There is talk of a thrombophilia (excess blood clotting / deep vein thrimbi) due to elevated levels of factor viii; this is a subspecialty hematologist question. ...Read more

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Factor viii inhibitor in hemophilia? What is a factor viii inhibitor?

Antibody to factor: Viii protein. People who are deficient in factor viii, i.e., have severe hemophilia, are treated with infusion of factor viii. Some make antibodies to factor viii and inhibit its function and are called factor viii inhibitors. Rarely non-hemophiliac can also develop such an inhibitor. ...Read more

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Why plasmapheresis is used to remove factor viii; could this be useful in a procoagulable state?

No.: Plasmapheresis removes all the clotting proteins, including factor viii, but the body rapidly replaces what is taken out. Usually all proteins are back to their usual levels within 24 hours. This would not be long enough to provide meaningful anti-coagulation. ...Read more

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What are the tests for factor viii deficiency?

What are the tests for factor viii deficiency?

Blood tests and: Family history. Blood tests for levels of factor viii are available, though simpler tests, e.g., PTT with appropriate family history may be sufficient. ...Read more

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What sort of disorder is factor viii deficiency?

R/o vWD: A patient with von willebrand's disease, which is extremely common and usually mild, may be told they have factor viii deficiency. ...Read more

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What are the symptoms of factor viii deficiency?

What are the symptoms of factor viii deficiency?

Bleeding/bruising: Factor viii deficiency or hemophilia- is a bleeding disorder. It is hereditary in most cases. The symptoms would be spontaneous bleeding- either in the joints, skin/gum, or other places etc or prolonged bleeding. The severity of bleeding will depend on how low the level of the factor viii is. Usually the bleeding episodes will manifest at early age. Discuss further with your hematologist. ...Read more

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Are a mildly elevated PTT and mildly elevated Coagulation Factor VIII Activity, as all as a high ALDO/PRA RATIO something to be concerned about and is there a correlation?

Are a mildly elevated PTT and mildly elevated Coagulation Factor VIII Activity, as all as a high ALDO/PRA RATIO something to be concerned about and is there a correlation?

PTT and ARR: Are a mildly elevated PTT and mildly elevated Coagulation Factor VIII Activity, as all as a high ALDO/PRA RATIO something to be concerned about and is there a correlation? ANS: no and No. I specialize in ARR problems. Happy to do 2nd opinion. ...Read more

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What is the prognosis for a person suffering from severe hemophilia, but getting regular factor viii replacement therapy?

What is the prognosis for a person suffering from severe hemophilia, but getting regular factor viii replacement therapy?

Excellent: One of my new colleagues has almost no factor viii but leads a near-normal life (no boxing or tackle football) on replacement. We can be thankful for biotechnology that has made this possible. ...Read more

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I just found out my daughter has a factor viii of 38. What does this mean? Doctor said to take her to hematologist.

I just found out my daughter has a factor viii of 38. What does this mean? Doctor said to take her to hematologist.

Little low: May have hemophilia a. Usually seen in men. Women can be carriers. Can have minor bleeding or asymptomatic. I agree that she needs to see a hematologist. She may require treatment with a drug called desmopressin if surgery is required. Check out site. Http://www. Ucdenver. Edu/academics/colleges/medicalschool/centers/hemophiliathrombosis/resources/documents/guide%20to%20mild%20hemophilia. Pdf. ...Read more

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What does a low von willebrand factor (vwf) ag: 33 %, low vwf activity: 29 % and factor viii activity: 52 % result mean?

What does a low von willebrand factor (vwf) ag: 33 %, low vwf activity: 29 % and factor viii activity: 52 % result mean?

VWD: First of all, these test need to be repeated at least one more time, prederably while you are off all medications. If persistently low, this may mean that you have von willibrand disease (VWD) which is a bleeding disorder. These are several types of VWD and more testing is needed to determine the type. You need to see a hematologist for this. Avoid any surgery and trauma. ...Read more

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I have type 2 von willebrands, severe, unknown subtype. I only respond to humate p (factor viii and von willebrand factor). Is there anything else I can take to help with minor bleeds.?

There are options: There are two other possibiliries that are approved "non-replacement" therapies for the treatment of VWD type 2a, in addition to humamte p there is Alphanate sd/ht. The other is called Koate dvi (factor viii) but this one is used in an off lable fasion for vwd. Read starting at page 50 here for more information. Only your hematologist should make any changes. Http://www. Nhlbi. Nih. Gov/guidelines/vwd/vwd. Pdf. ...Read more

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Can you tell me if someone is heterozygous w/ the hemophilia gene, is it possible for them to still have factor viii deficiency?

Can you tell me if someone is heterozygous w/ the hemophilia gene, is it possible for them to still have factor viii deficiency?

Yes, in men: Hemophilia is a sex linked disorder and men develop the disease when there only x chromosome has the defective gene. See this site for more info.
http://www. Nlm. Nih. Gov/medlineplus/ency/article/000538.htm. ...Read more

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Was taking a recombinant-derived fviii for hempohilia a and inhibitor appear. Finishing iti and doc says 2 try plasma fviii. Alphanate (factor viii and von willebrand factor) or koate and y?

Follow his advice: Development of recombinant factor v111 inhibitor those occur frequently after prolonged treatment and those make the treatment less effective. Hence your dr will recommend products to bypass the inhibition. ...Read more

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What to do along with Factor VIII for severe hemarthrosis along with large joint effusion of knee in patient with Hemophilia A?

What to do along with Factor VIII for severe hemarthrosis along with large joint effusion of knee in patient with Hemophilia A?

Xfusion with factor-: -Vlll, then aspiration of the joint. Chronic hemarthrosis destroys the articular cartilages. It consumes O2, & does not allow it 2 B nourished. Cartilages only O2 comes from the joint fluid, but it's not available since the inflammatory reaction 2 the blood consumes it ...Read more

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I asked earlier about my daughter. She went to the doctor for heavy periods. She gets nose bleeds. She was found to have factor viii. She is 13.

I asked earlier about my daughter. She went to the doctor for heavy periods. She gets nose bleeds. She was found to have factor viii. She is 13.

With that history,: Von willebrand disease is the mostly likely cause out of the 3 possibilities I gave you. There are 3 types of vwd, all of which can be managed so your daughter can live an active, healthy life once you & she learn what to do. See http://www. Nhlbi. Nih. Gov/health/health-topics/topics/vwd/. ...Read more

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What is the treatment for factor viii deficiency?

What is the treatment for factor viii deficiency?

Factor VIII: Concentrate. Factor viii is prepared by recombinant technology, though it may also be extracted from human plasma. Depending on the severity of deficiency, factor viii may be given prophylactically or to treat episodes of bleeding. The drug is given intravenously. ...Read more

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Heterozygous for MTHFR, have high Protein C & Fact, VIII. Taking 3mg methylfolate for 3 mo, homocysteine normal. Reason to follow up w. hematologist?

Heterozygous for MTHFR, have high Protein C & Fact, VIII. Taking 3mg methylfolate for 3 mo, homocysteine normal. Reason to follow up w. hematologist?

No: Forgive my frankness. Most of us pathologists do not believe in this MTHFR screening being promoted by a lab to physicians worried about liability. A majority of folks test "abnormal" and are then offered questionable vitamin supplements. Reference ranges arbitrarily put several percent of healthies outside; high protein C and factor VIII are not worrisome especially if you feel well. ...Read more

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Is height a hereditary factor?

Is height a hereditary factor?

Yes, largely it is.: Agree with dr. Lewy weiss. It is unlikely that a person born to short parents will be tall. ...Read more

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What factors determine our daily caloric needs?

What factors determine our daily caloric needs?

Daily calories.: To match your caloric need with caloric intake and be weight-neutral, you’d need to consider your basal metabolic rate and daily energy expenditure through activity. ...Read more