Doctor insights on:
Exocrine Pancreatic Insufficiency
Control is ok: Exocrine pancreatic insufficiency is often the result of recurrent episodes of pancreatic inflammation and is not often cured. Symptoms result from inadequate enzymes released into intestine to assist digestion. Replacement enzymes can alleviate symptoms when taken pre meal. ...Read more
Abdominal organ. It is digestive organ: it secretes enzymes into the small bowel which break down food and help its absorption. It is also an endocrine organ: it produces hormones involved in sugar control and control of digestion. Insulin is one of these hormones. Diabetics either lack Insulin (type 1 diabetes) or have inadequate ...Read more
Digestive Enzymes: The pancreas' main exocrine function is to produce enzymes which help digest carbs, protein, and fats. These enzymes are made in acinar cells and travel down a duct to the small intestine (2nd stage of duodenum). Insufficiency can either be from an obstruction in said duct or a decreased synthesis of the enzymes from damage or fibrosis of pancreatic tissue, most commonly secondary to pancreatitis. ...Read moreSee 1 more doctor answer
Pancreas: You must spend time with your doctor who will do what is needed. You may also need to be seen by a Specialist. All should go well! ...Read more
What things can cause pancreatic exocrine insufficiency, apart from alcohol? Provide an answer for the patient who never imbibes alcohol.
Destruction: Pancreatic exocrine insufficiency typically occurs after destruction of the pancrease, (pancrelipase) usually from chronic pancreatitis. Causes include, gallstones, alcohol, hi triglycerides, autoimmune, hemachromatosis, medications, pancreatic divism ; sphincter of odi dysfunction. Other causes could be cystic fibrosis, cancer/tumor growth, sarcoidosis, amyloidosis, or idiopathic. ...Read more
"human pancreatic exocrine response to nutrients in health and disease" bmj 2005 figure 2 says lipase post-lundh meal should rise 5x. Is this correct?
Maybe, but...: That graph is a generalization, based on other scientists' studies (one would have to review the original studies). The graph shows pancreatic "enzyme delivery into the duodenum increases rapidly and reaches maximal values within the first postprandial hour", which means it's an estimate of the amount of enzyme put into the small intestine to digest food... Not a measure of lipase on a blood test. ...Read more
How do you know if and when you've lost exocrine function and how long does it take for this to occur ?
What : Do you mean Endocrine function???Get a more detailed answer ›
Pancreas: Endocrine hormones are secreted into the bloodstream to cause effects in other parts of the body. The pancreas secretes Insulin and glucagon to cause these effects. Exocrine hormones are secreted into body cavities with tubes connecting the producing gland into a body cavity. The pancreas secretes a variety of substances into the intestinal tract. ...Read more
Might be: There is definitely a reported relationship between inflammatory bowel disease (uc and crohn's) and pancreatic insufficiency. It isn't entirely clear why. Proposed mechanisms include (a) the same auto-immune process that attacks the bowel attacks the pancreas (b) repeated episodes of pancreatitis some of which may be medication side-effects. You may need Creon for life. ...Read more
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