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Doctor insights on: Primary Biliary Cirrhosis

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Dr. John Landi
64 doctors shared insights

Primary Biliary Cirrhosis (Overview)

A chronic disease in which the bile ducts in the liver are slowly destroyed.


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What exactly is primary biliary cirrhosis?

What exactly is primary biliary cirrhosis?

Liver disease: Primary biliary cirrhosis is an autoimmune liver disease seen most commonly in women in the 4th to 5th decade of life. It generally presents with unexplained itching and occasionally jaundice. It is frequently found on routing screening liver tests which may show an elevated alkaline phosphotase. Though not curable it is treatable and treatment slows the progression to cirrhosis. ...Read more

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Dr. John Landi
64 doctors shared insights

Primary Biliary Cirrhosis (Overview)

A chronic disease in which the bile ducts in the liver are slowly destroyed.


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What is the liver biliary atresia?

What is the liver biliary atresia?

Biliary atresia: Biliary atresia is a congenital scarring of the biliary ducts. These ducts transport bile made in the liver to the intestine so one can digest fats. The ducts scar and obliterate. Bile then cannot exit the liver which poisons the liver. These infants need corrective surgery before they are 2 months old. ...Read more

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Is primary biliary cirrhosis hereditary?

Basically no: There's a pair of genes that carry the ability to develop the disease and these run in families, but it's not inherited like sickle cell, huntington's or some of the other familiar entities. http://www.medicalnewstoday.com/releases/151640.php. ...Read more

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What is primary biliary cirrhosis (liver) like?

What is primary biliary cirrhosis (liver) like?

It's variable.: Depends on how long you have had it. Usually without symptoms early in the disesae. May be associated with itching, hypythyroidism, fatigue, osteoporosis and dry eyes. Can progress to cirrhosis over time. If you have pbc, you should talk with your doctor about what stage your disease is. ...Read more

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What exactly is biliary atresia?

What exactly is biliary atresia?

Birth defect: Malformation and scarrng obliteration of the bile ducts. Starts at birrth and progresses. Any infant who is jaundiced after one month of age needs a bilirubim level and a gallbladder ultrasound. Will need surgical correction prior to 60 days of life. ...Read more

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What is chronic liver parenchymal disease with cirrhosis; varices and ascites?

What is chronic liver parenchymal disease with cirrhosis; varices and ascites?

This sounds serious: To translate, you have liver cell damage and scarring (cirrhosis), which caused abnormally elevated portal vein pressures which caused venous distention in esophagus (varices). You also developed fluid in abdominal cavity, because of the high portal vein pressure. This imaging study is showing advanced stage of liver disease. You must get a specialist to treat you. ...Read more

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What exactly causes biliary atresia?

What exactly causes biliary atresia?

See below: The causes of biliary atresia are not well established and are probably multifactorial; genetic factors may play a permissive role in some cases, but infectious, toxic, or immunologic mechanisms are probably involved. ...Read more

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Pathophysiology of liver cirrhosis?

See below: Scar tissue in the liver as a result of different kinds of injuries. The significance is related to the chronicity for the injury and especially whether the injury is ongoing. ...Read more

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Why is igm elevated in primary biliary cirrhosis (cholangitis)?

Why is igm elevated in primary biliary cirrhosis (cholangitis)?

Immune dysregulation: The immune system is not functioning normally in primary biliary cirrhosis. That and the chronic inflammation contrive to raise IgM. ...Read more

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What is 'pancreas biliary system'?

Pancrease (pancrelipase) and biliar: The biliary system is a collection of tubes that end in gall bladder. The panreatic duct arises in pancreazse and joins common bile duct. This tube empties into small intestine just past end of stomach. ...Read more

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What differentiates primary biliary cirrhosis from other types of cirrhosis?

What differentiates primary biliary cirrhosis from other types of cirrhosis?

Location of inflam: Agree with dr. Edmisson. Pbc is autoimmune disease affecting bile ducts; can eventually lead to progressive liver disease and cirrhosis (scarring). Othe types of cirrhosis usually involve inflammation of the liver cells, due to infection (like hep b, c), toxic chemicals, metabolic disease e.g.Nonalcoholic fatty liver (seen in obesity, diabetes) iron overload, damage from alcohol, autoimmune. ...Read more

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Can biliary hyperkinesia damage gallbladder, pancreas, liver, or biliary tree? My ultrasound was normal, but ejection fraction=91%.

Yes, biliary: Dyskinesia can cause damage, and it can also be a result of pathology in pancreas, liver or biliary tree. Byt 91% ejection is normal. Consult with a surgeon or GI specialist for specific recommendation. ...Read more

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What can you tell me about end stage liver failure/end stage liver cirrhosis?

What can you tell me about end stage liver failure/end stage liver cirrhosis?

Can vary: Cirrhosis can lead to complications like fluid build up in your abdomen (ascites), confusion (hepatic encephalopathy), varices that can bleed, and liver cancer (HCC) as well as easy bruising, fatigue and jaundice (elevated bilirubin) can occur. You need to be followed by a liver doctor who can manage and control the above signs/symptoms and discuss liver transplantation. ...Read more

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What distinguishes pancreas, liver, colon, kidney, prostate and gallbladder cancers?

What distinguishes pancreas, liver, colon, kidney, prostate and gallbladder cancers?

Cure varies: Beyond the obvious differences in organ and cell type as well as the various treatment approaches, the most important patient difference is really the chance at cure. Early stage prostate and renal cell (kidney) cancers can be very curable. Even really early stage pancreatic cancers can be quite deadly. ...Read more

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Liver Cancer patient SGPT(ALT)=84 U/L, SGOT(AST)=121 U/L, BILIRUBIN=10.91 with no bile duct obstrcton in Ultra Sound. Does this mean liver is failing?

Liver Cancer patient SGPT(ALT)=84 U/L, SGOT(AST)=121 U/L, BILIRUBIN=10.91 with no bile duct obstrcton in Ultra Sound. Does this mean liver is failing?

Can't tell w/ these.: The bilirubin level is high (whether direct or indirect bilirubin) & this can lead to jaundice. However, the TREND is more important than 1 lab value - without knowing your history & past lab results better, it is hard to determine. Also, liver "function" is also measured by cholesterol, complement, & coagulation tests (INR, PTT). Even with these blood tests, sometimes a biopsy is needed. TTYD. GL ...Read more

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What is advanced liver fibrosis?

What is advanced liver fibrosis?

Cirrhosis: Another term will be cirrhosis or replacement of normal tissue by scar tissue. ...Read more

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Dr. Eric Weisman
1 doctor shared a insight

Biliary (Definition)

Biliary means anything related to the production, storage, secretion, or flow of bile, whether in the liver, bile ducts, gallbladder, ...Read more


Upper Abdomen (Definition)

Draw a transverse line through the umbilicus and the upper abdomen includes every part of the belly above this line and below the ...Read more