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Doctor insights on: Evista Tamoxifen Breast Cancer

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Is evista (raloxifene) as effective as tamoxifen in reducing breast cancer?

Is evista (raloxifene) as effective as tamoxifen in reducing breast cancer?

Yes (and no): The study of tamoxifen and Raloxifene (star) trial compared the effectiveness of these two drugs in the prevention of breast cancer and found them to be equally effective, with a 50% reduction in invasive breast cancer as compared to placebo. However, only tamoxifen reduced the rate of carcinoma in situ (dcis, lcis). ...Read more

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Dr. Barry Rosen
1,336 doctors shared insights

Breast Cancer (Female) (Definition)

Breast cancer results when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. The growth occurs initially inside the ducts but eventually breaks outside into the breast tissue and ultimately spreads both to the lymph nodes in the armpit and via the bloodstream to other parts of the body. Because of the promoting affect of estrogen almost all breast cancer occurs in women and is a rarity in men. The unregulated growth is due to both inherited and acquired genetic defects. It is the most common malignancy in women but it often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast on an annual basis. ...Read more


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What could happen if someone took tamoxifen if they didn't have breast cancer?

What could happen if someone took tamoxifen if they didn't have breast cancer?

Talk to your doctor: Tamoxifen has other indications aside from treatment of breast cancer such as reducing the risk of breast cancer in women who carry high risk for developing breast cancer. It has many side effects that need to be taken into consideration before taking this medicine. It needs to be prescribed by a health care provider who is familiar in its indications and side effects. Do not take it on your own. ...Read more

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Is combined tamoxifen plus hormonal therapy better for breast cancer in pre or postmenopausal women?

Is combined tamoxifen plus hormonal therapy better for breast cancer in pre or postmenopausal women?

Estrogen supression: In general, aromatase inhibitor is only indicated for postmenopausal women ;not for premenopausal; while on the other hand, tamoxifen can be given either in pre or postmenopausal. Only thing is that tamoxifen can cause a little bit higher risk for complication -i.e. Risk for blood clots and risk for develping uterine cancer- when used in older population- age of -65 Y.O. Or above. ...Read more

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How high are my risk of endometrial cancer. I am a breast cancer survivor of 6 yrs. Am on tamoxifen. My sister was diagnosed with endometrial cancer,?

How high are my risk of endometrial cancer. I am a breast cancer survivor of 6 yrs. Am on tamoxifen.  My sister was diagnosed with endometrial cancer,?

Very low: Endometrial cancer is rarely hereditary, so it is highly unlikely that you will have this problem due to the fact that your sister had it. Breast cancer is not associated with it either. Tamoxifen usage has some small increased risk for endometrial but it can be easily monitored with once yearly Ultrasound test of your uterus. Do tell us know if you have any problems ...Read more

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Does pr-negative breast cancer respond to tamoxifen?

Does pr-negative breast cancer respond to tamoxifen?

It depends.: Tamoxifen is used to treat hormone-sensitive breast cancer. This is determined by checking for estrogen receptors (er) and Progesterone receptors (pr) on the cancer. If the cancer is er+ and pr- (or vice-versa), it should respond to tamoxifen. However, if the cancer is er- and pr-, tamoxifen is not effective. ...Read more

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Are there any other alternatives to tamoxifen for breast cancer?

Are there any other alternatives to tamoxifen for breast cancer?

Additional info: Also let me add additional alternatives if pre-menopausal 1) bilateral oophorectomy (surgical or radiation) 2) chemical oophorectomy (goserelin or gnrh agonist). If this were chosen your oncologist might recommend aromatase inhibitor therapy, although this is a controversial topic. ...Read more

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I was wondering what would happen if someone took tamoxifen if you didn't have breast cancer?

I was wondering what would happen if someone took tamoxifen if you didn't have breast cancer?

May surprise you but: ...Folks with high risk for breast cancer (without cancer) can take it to reduce their risk. It's not for everybody and should be done under the care of a specialist in the field. Anybody else will get the side effects (hot flashes and increased risk for blood clots and uterine cancer) for no gain at all. ...Read more

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When do breast cancer patients need tamoxifen ?

When do breast cancer patients need tamoxifen ?

Tamoxifen: A selective estrogen receptor modulator is effective added therapy for women with well-differentiated, estrogen receptor positive breast cancers. ...Read more

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What is the role of tamoxifen in the treatment of breast cancer?

What is the role of tamoxifen in the treatment of breast cancer?

Chemotherapy: Tamoxifen is a very effective drug for the treatment of hormone-sensitive (estrogen receptor +) breast cancers. It may be used alone or in combination with traditional IV chemotherapy, depending on the cancer stage. Furthermore, tamoxifen has been shown to be effective reducing the chance of developing breast cancer in high-risk women ("chemoprevention"). ...Read more

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When is tamoxifen for breast cancer treatment?

When is tamoxifen for breast cancer treatment?

Chemotherapy: Tamoxifen is a very effective drug for the treatment of hormone-sensitive (estrogen receptor +) breast cancers. It may be used alone or in combination with traditional IV chemotherapy, depending on the cancer stage. Furthermore, tamoxifen has been shown to be effective reducing the chance of developing breast cancer in high-risk women ("chemoprevention"). ...Read more

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Dr. Barry Rosen
4,214 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more