Doctor insights on:
Estrogen Receptor Er Positive Breast Cancer Adjuvant Taxol Benefits
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
D/W oncologist: Treatment will depend not only the stage but also the biology of the cancer- whether it is estrogen positive, her2neu positive, whether it is lymph node positive or not. Also depends on your preference and overall health condition. Different test like oncotype dx, mammaprint can give you more info-re- recurrence risk of cancer and will be helpful in choosing the right therapy for you.D/w your md. ...Read moreSee 2 more doctor answers
Is there a benefit to chemotherapy in hormone receptor positive, node positive postmenopausal breast cancer?
Often: There is increasing data based on the oncotype DX test in women with 1-3 positive notes that shows that some women will not get much benefit from chemo and some will get a great deal. It can be useful in cases where a woman is reluctant to take chemo. This is done on tissue that has been already removed. Most oncologists believe that women who have multiple positive nodes should get chemotherapy. ...Read moreSee 1 more doctor answer
It depends.: Tamoxifen is used to treat hormone-sensitive breast cancer. This is determined by checking for estrogen receptors (er) and Progesterone receptors (pr) on the cancer. If the cancer is er+ and pr- (or vice-versa), it should respond to tamoxifen. However, if the cancer is er- and pr-, tamoxifen is not effective. ...Read moreSee 2 more doctor answers
Unclear Question?: These are somewhat unrelated questions which makes it difficult for me to address your question. Evista (raloxifene) is not used for treating cancer...It is sued for treatment/prevention of osteoporosis. Estrogen receptors are specialised protein receptors found in breast cancer.Uterine cancer has little bearing on either of the two references you have listed. ...Read more
Up to 1 year's worth: Herceptin (trastuzumab) can be given together with initial chemotherapy for the first 4-6 months then subsequently by itself for a total of 1 year. If chemotherapy was given first without Herceptin (trastuzumab) then Herceptin (trastuzumab) can be given for a full year by itself. The usual cycle runs every 3 weeks (17-18 cycles in one full year). ...Read moreSee 1 more doctor answer
Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?
Estrogen: Tamoxifen is given to individuals with specific breast cancers that are driven to grow by the presence of estrogen receptors. Tamoxifen interferes with the activity of estrogen in the breast, preventing cancer growth. The role of Progesterone receptors is unclear, though Progesterone receptors in breast cancer are generally associated with estrogen receptors, making tamoxifen an effective therapy. ...Read moreSee 2 more doctor answers
Ciii ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin. In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?
Many options: Choosing chemo depends on many factors, so only your doctor can decide what might work for you. Drugs you haven't mentioned include altretamine, capecitabine, cytoxan, (cyclophosphamide) vinorelbine, ifosfamide, etoposide, and irinotecan. There are also several hormonal agents. And a clinical trial might be an option. Check out www.Cancer.Gov for more info. And good luck. ...Read moreSee 1 more doctor answer
32 YO, triple positive, grade 3, stage 1B breast cancer. TCH chemotherphy, had dbl mastectomy. What is survival rate?
Need Clarification!: Are you sure your breast cancer was triple positive(or was it triple Negative)??? TCH is commonly used chemotherapy for triple negative, so please double check and let us know. Then we can give you survival figures. In general, small tumors(Stage 1 and stage 2) have very good survival rate and high cure rates. ...Read more
Stage 2B IDC breast cancer, her2+/ER/PR+Neoadjuvant taxol, (paclitaxel)A/C,lumpectomy,rads, lymphovascular invasion. What does this mean for prognosis & follow up?
Prognosis fair: Stage IIb breast cancer is usually palpable at 2-5 cm. and at time of procedure to remove lesion, sentinel nodes are + suggesting axillary dissection and reason for neoadjuvant therapy. Lymphovascular invasion increases chance for recurrence. With Her2+ Herceptin (trastuzumab) with chemo should be used and PET/CAT needed to assure met foci not missed in distal organs. Carful follow up needed. ...Read more
Feeds the cancer: Most breast cancers are estrogen receptor positive. The cancer cells have receptors that fit the estrogen molecule that a body produces. Think: a lock and key - when estrogen binds to the receptor the tumor cell is stimulated to grow and divide. Er+ tumors can be blocked by tamoxifen and Arimidex (anastrozole) (and others) that interfere with this pathway. ...Read moreSee 2 more doctor answers
What should a person with breast cancer IV take after tamoxifen and aromasin. Arimidex femara or faslodex (fulvestrant)?
Treatment options: For stage IV breast cancer- if the cancer progressed after tamoxifen and aromasin- depending on several factors such as how much cancer burder, involvement to visceral organs, overall condition etc- the options would be- faslodex; combination of Aromasin (exemestane) and evorilimus ( based on recent randomized clinical trial) or chemotherapy. Discuss further with your oncologist- which one for your case. ...Read moreSee 1 more doctor answer
Please clarify.: It is unclear from your question what you are asking. Most breast cancers are estrogen-sensitive and can be treated with anti-estrogen medication (tamoxifen, aromatase inhibitors). Many women who are peri menopausal when receiving traditional chemotherapy develop ovarian suppression from the chemo and effectively "go into" menopause. I hope this helps. ...Read more
An organ, cell or molecule that accepts an outside signal and causes an internal change. Eyes receive light, touch receptors send messages to the brain when stimulated by pressure and estrogen receptors bind Estradiol causing responses of normal breast, ovary and uterus cells to rising and falling levels of the female steroid hormones. Most of the time "receptor" refers to one ...Read more
An estrogen receptor is a protein found on some cells in the human body that is activated by the hormone estrogen. Once activated, the receptor sends a signal to the cell nucleus to activate certain genes. In breast cancer, the tumor is tested to determine if estrogen receptors are present on the malignant cells; if they are present, then anti-estrogen therapy is given as a ...Read more
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