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Doctor insights on: Estrogen Progesterone Make Breast Cancer

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If I have too much estrogen, or not enough progesterone, does that make me more susceptible to breast cancer?

If I have too much estrogen, or not enough progesterone, does that make me more susceptible to breast cancer?

High E2/Prog is NG: A high estrogen/progesterone ratio is a contributing factor to many medical and metabolic problems. Breast, ovarian, cervical cancer, pms. High e2/prog ratio will activate your parasympathetic nervous system and cause symptoms from excess vagal stimulation. Have your doctor check your e2 and prog during mid luteal phase of your menstrual cycle (day 18-21). ...Read more

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Dr. Barry Rosen
1,336 doctors shared insights

Breast Cancer (Female) (Definition)

Breast cancer results when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. The growth occurs initially inside the ducts but eventually breaks outside into the breast tissue and ultimately spreads both to the lymph nodes in the armpit and via the bloodstream to other parts of the body. Because of the promoting affect of estrogen almost all breast cancer occurs in women and is a rarity in men. The unregulated growth is due to both inherited and acquired genetic defects. It is the most common malignancy in women but it often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast on an annual basis. ...Read more


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I have breast cancer-Her 2 positive, progesterone & estrogen positive. On my health record it shows I have breast cancer (HCC). What does HCC mean?

I have breast cancer-Her 2 positive, progesterone & estrogen positive. On my health record it shows I have breast cancer (HCC). What does HCC mean?

IHC?: Does it say IHC? Immunohistochemistry. Immunohistochemistry is an array of stains used to confirm a specific type of cancer. They probably used this to tell if estrogen and progesterone positive. Hope this helps. ...Read more

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Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Individual: Yes, estrogen alone does increase the risk of uterine cancer over time. And yes the whi showed that the combination of a certain synthetic estrogen and a certain synthetic progestin increased the risk of breast cancer. But most specialists do not use those older types of synthetic hormones and with newer medications the risks are lower and different. So a balance can be achieved. ...Read more

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Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Estrogen: Tamoxifen is given to individuals with specific breast cancers that are driven to grow by the presence of estrogen receptors. Tamoxifen interferes with the activity of estrogen in the breast, preventing cancer growth. The role of Progesterone receptors is unclear, though Progesterone receptors in breast cancer are generally associated with estrogen receptors, making tamoxifen an effective therapy. ...Read more

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How do breast cancer anti estrogen pills work?

Starve tumor: Many tumors are fed by estrogen - the main female horomone. Anti-estrogen pills block the effects of estrogen (in a variety of different ways) and thereby starve the tumor from a vital growth factor. Even if you are postmenopausal (or even male) your body still produces estrogen in places like the adrenals and subcutaneous fat. ...Read more

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Does natural progesterone prevent breast cancer?

Does natural progesterone prevent breast cancer?

No: There is no evidence Progesterone of any type prevents breast cancer, "natural" Progesterone or not. If a woman has menses that only occur a few times a year, six or four or fewer, however, Progesterone or progesterone-like compounds can very definitely prevent endometrial hyperplasia (which can lead to uterine cancer), and should be used regularly to oppose continuous estrogen stimulation. ...Read more

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What is estrogen receptor positive breast cancer?

One with receptors.: These are tumors with estrogen receptors on them. This makes them susceptable to some chemotherapeutic agents, like tamoxifen. ...Read more

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What is meant by having estrogen receptor positive breast cancer?

What is meant by having estrogen receptor positive breast cancer?

Feeds the cancer: Most breast cancers are estrogen receptor positive. The cancer cells have receptors that fit the estrogen molecule that a body produces. Think: a lock and key - when estrogen binds to the receptor the tumor cell is stimulated to grow and divide. Er+ tumors can be blocked by tamoxifen and Arimidex (anastrozole) (and others) that interfere with this pathway. ...Read more

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Dr. Barry Rosen
4,214 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


Dr. Seth Derman
1,129 doctors shared insights

Progesterone (Definition)

Progesterone has been found to be helpful in preventing preterm birth in a patient who has a history of delivering babies too early. It can be given as vaginal suppositories. It is most often given as weekly ...Read more