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Doctor insights on: Estrogen Progesterone Make Breast Cancer

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If I have too much estrogen, or not enough progesterone, does that make me more susceptible to breast cancer?

If I have too much estrogen, or not enough progesterone, does that make me more susceptible to breast cancer?

Breast cancer risk: Maybe: some breast cancers take up estrogen as a sort of growth hormone to encourage growth, so too much estrogen can speed growth of these cancers. There is a very small increase in breast cancer risk with estrogen only given postmenopausally for the symptoms. Relative increase in Progesterone only is associated with some breast disorders also but cancer risk is unclear. ...Read more

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Dr. Barry Rosen
4,316 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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I have breast cancer-Her 2 positive, progesterone & estrogen positive. On my health record it shows I have breast cancer (HCC). What does HCC mean?

I have breast cancer-Her 2 positive, progesterone & estrogen positive. On my health record it shows I have breast cancer (HCC). What does HCC mean?

IHC?: Does it say IHC? Immunohistochemistry. Immunohistochemistry is an array of stains used to confirm a specific type of cancer. They probably used this to tell if estrogen and progesterone positive. Hope this helps. ...Read more

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Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Individual: Yes, estrogen alone does increase the risk of uterine cancer over time. And yes the whi showed that the combination of a certain synthetic estrogen and a certain synthetic progestin increased the risk of breast cancer. But most specialists do not use those older types of synthetic hormones and with newer medications the risks are lower and different. So a balance can be achieved. ...Read more

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Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Estrogen: Tamoxifen is given to individuals with specific breast cancers that are driven to grow by the presence of estrogen receptors. Tamoxifen interferes with the activity of estrogen in the breast, preventing cancer growth. The role of Progesterone receptors is unclear, though Progesterone receptors in breast cancer are generally associated with estrogen receptors, making tamoxifen an effective therapy. ...Read more

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How do breast cancer anti estrogen pills work?

Starve tumor: Many tumors are fed by estrogen - the main female horomone. Anti-estrogen pills block the effects of estrogen (in a variety of different ways) and thereby starve the tumor from a vital growth factor. Even if you are postmenopausal (or even male) your body still produces estrogen in places like the adrenals and subcutaneous fat. ...Read more

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Does natural progesterone prevent breast cancer?

Does natural progesterone prevent breast cancer?

No: There is no evidence Progesterone of any type prevents breast cancer, "natural" Progesterone or not. If a woman has menses that only occur a few times a year, six or four or fewer, however, Progesterone or progesterone-like compounds can very definitely prevent endometrial hyperplasia (which can lead to uterine cancer), and should be used regularly to oppose continuous estrogen stimulation. ...Read more

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What is estrogen receptor positive breast cancer?

What is estrogen receptor positive breast cancer?

One with receptors.: These are tumors with estrogen receptors on them. This makes them susceptable to some chemotherapeutic agents, like tamoxifen. ...Read more

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What is meant by having estrogen receptor positive breast cancer?

What is meant by having estrogen receptor positive breast cancer?

Feeds the cancer: Most breast cancers are estrogen receptor positive. The cancer cells have receptors that fit the estrogen molecule that a body produces. Think: a lock and key - when estrogen binds to the receptor the tumor cell is stimulated to grow and divide. Er+ tumors can be blocked by tamoxifen and Arimidex (anastrozole) (and others) that interfere with this pathway. ...Read more

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Should a 65-year old woman with a family history of breast cancer continue estrogen?

Should a 65-year old woman with a family history of breast cancer continue estrogen?

Probably not.: This can increase the risk for some breast cancers and endometrial cancer. Having a family history does not help. However, low dose hormone replacement therapy may be possible. It would be wise to see your doctor to be sure. ...Read more

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How much estrogen gets into system using vaginal estrogen. Family history of breast cancer but not me. ?

How much estrogen gets into system using vaginal estrogen. Family history of breast cancer but not me. ?

Varies: Per the med insert: Premarin (conjugated estrogens) Vaginal Cream should not be used if you have unusual vaginal bleeding, have or had cancer, had a stroke or heart attack, have or had blood clots or liver problems, have a bleeding disorder, are allergic to any of its ingredients. This is due to significant absorption thru the vaginal mucosa which is dose dependent. Not the same risk for someone with family history only ...Read more

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Im on estrogen pills how long should I take them before they run a risk of causing breast cancer and should they be took along?

Im on estrogen pills how long should I take them before they run a risk of causing breast cancer and should they be took along?

5 yrs or less: It has been shown that using hormone replacement therapy (hrt) can increase one's risk of breast cancer when taken for longer than 5 years. Because of this we no longer recommend taking hormones for long periods of time. Work with your gynecologist for options to deal with the symptoms of menopause. ...Read more

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What is the role of estrogen in breast cancer?

What is the role of estrogen in breast cancer?

Stimulates the growt: About 80% of breast cancer are er positive which means that the cancer cells are stimulated to grow by estrogen in the body. Decreasing the estrogen levels with tamoxifen which is an estrogen blocker in premenopausal women and aromatase inhibitors which stop estrogen production in sites other than the ovaries in post menopausal women is an important treatment. ...Read more

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Do high estrogen levels cause breast cancer in men?

Do high estrogen levels cause breast cancer in men?

IT'S A RISK FACTOR: Prolonged exposure to estrogen is a risk factor for breast cancer in men. Obesity, liver cirrhosis and high alcohol intake can lead to a high estrogen state. ...Read more

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Is it true that estrogen increases the risk of breast cancer?

Is it true that estrogen increases the risk of breast cancer?

HRT-yes: The use of hormone replacement therapy (hrt) for menopause has been shown to increase the risk for breast cancer when used longer than 5 years. Oral contraceptives do not have any relation nor increase in risk of breast cancer. ...Read more

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If I had breast cancer, can I take estrogen in menopause?

If I had breast cancer, can I take estrogen in menopause?

Probably not: You should speak with your oncologist, however, Estrogens are usually not recommended if you have had breast cancer. ...Read more

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Why do we give anti-estrogen drugs to post-menopausal women with breast cancer?

Why do we give anti-estrogen drugs to post-menopausal women with breast cancer?

Anti-estrogen drugs: Anti-estrogen drugs are given to both premenopausal and postmenopausal women whose cancer is estrogen receptor-positive or progesterone receptor-positive. These cancer may grow when exposed to estrogen. Anti-estrogen medications block or reduce estrogen that is normally produced by the ovaries in premenopausal women or by fat cells, liver, adrenal glands or other organs in postmenopausal women. ...Read more

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What can I do for hot flashes can't take estrogen due to breast cancer in family I lost my mom to cancer?

What can I do for hot flashes can't take estrogen due to breast cancer in family I lost my mom to cancer?

SSRI;s: Selective Serotonin Reuptake Inhibitors (SSRI's) commonly known as a class of anti-depressants can be effective in minimizing hot flashes. Talk to your GYN MD about this and any other alternatives to estrogen Rx's that may be available. ...Read more

Dr. Barry Rosen
1,365 doctors shared insights

Breast Cancer (Definition)

Occurs when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. Often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast ...Read more


Dr. Mark Hoepfner
1,050 doctors shared insights

Breast Carcinoma (Definition)

Most breast cancers are carcinomas. This is a type of breast cancer. These cancers start in the cells that line organs and tissues. In fact, breast cancers are often a type of carcinoma called adenocarcinoma, which starts in cells that make glands (glandular tissue). Breast adenocarcinomas start in the ducts (the milk ducts) or ...Read more