Doctor insights on:
Essential Thrombocythemia Jak2 Positive
ET: It is a condition under myeloproliferative neoplasme umbrella where- for unclear reason- bone marrow produce too much platelet that can go beyond a million. They are sticky and abnormal platelets that can cause blood clots or bleeding. Myeloproliferative neoplasm can transform into acute leukemia. The risk of et to develop acute leukemia is about 5%. Discuss further with your hematologist. ...Read more
ET: Et is one of the myeloproliferative neoplasms. It causes overproduction of platelets and a susceptibility to clotting and, occasionally, bleeding problems. Whether one needs treatment depends on the patient's age, previous disease-related complications, and underlying cardiovascular status. Several good support groups can be found on the internet. ...Read more
Quite common: For the whole population, maybe 1 person in 2000. It's more common in older folks, less so in youngsters. ...Read more
Yes: Treatment of essential thrombocythemia depends on your risk of blood-clotting or bleeding episodes. If you're younger than 60, have had no signs or symptoms, and have no other risk factors for developing blood clots, such as smoking, you may simply need periodic medical checkups. ...Read more
ET treatment: A drug called hydroxy-urea will be the treatment to reduce platelet levels. Then on the high risk group, Aspirin will be needed too. Discuss in detail with your hematologist. ...Read more
Yes-5% risk: Essential thrombocythemia is part of myeloprolifeartive neoplasm umbrealla where in et the bone marrow for some uknown reason-proliferate too much platelet- that can go up above a million. They are abnormal and sticky platelet. Due to the abnormal level and function of platelet, there would be risk for blood clots as well as bleeding. The risk of et to develop into acute leukemia is about 5 %. ...Read more
Neoplasm: Essential thrombocythemia (et) is part of group of myeloproliferative neoplasm (mpn) - is a clonal disorder. Mpns are predisposed to clonal evolution and disease transformation to myelodysplasia and/or acute leukemia. The propensity to transform into acute myeloid leukemia differs among the subgroups- being the highest for cml- greater than 90% if left untreated and et being the least - about 5%. ...Read more
Platelets: Need more information like what is your platelts count and any symptoms. No symptom-no treatment. Since you have diagnosis of essential thrombocythemia and tested positive for philadelphia chromosome mean you have hematologist who has ruled out other causes of thrombocythemia and any lymphocytic leukemia connection. Please stay in touch with hematologist. Wish you best of health. ...Read more
ET: Hydroxyurea, anagrelide, and alpha-interferon are conventional therapies for essential thrombocythemia. Pipobroman is widely used in europe, but not available in the United States. Low-dose Aspirin is possibly effective in preventing thrombosis (clot formation) in et. Low-dose asa is especially effective in managing the vasomotor symptoms of et. ...Read more
I have had essential thrombocythemia but suddenly my platelets have dropped low. What could this be?
Many issues: You should see your doctor. Some issues are better discussed in person. ...Read more
Too many platelets: The myeloproliferative neoplasms (mpns) involve terminal myeloid cell expansion in the peripheral blood, resulting in various combinations of erythrocytosis (rbc's), leukocytosis (wbc's), thrombocytosis (platelets), bone marrow hypercellularity/fibrosis, and splenomegaly (enlarged spleen). Essential thrombocythemia is a diagnosis of exclusion, made when other forms of mpn are ruled out. ...Read more
Too many platelets: Myeloproliferative disorders are a set of marrow malignancies characterized by excessive production of certain types of blood cells. Essential thrombocytopenia is one of them, in which marrow makes too many platelets. There are well-tolerated oral agents which help. Other myelodysplastic syndromes are polycythemia vera and chronic myelogenous leukemia. ...Read more
See below: Polycythemia vera (PV) is characterized by uncontrolled production of red blood cells along with specific JAK2 gene mutation and decreased EPO level. Essential thrombocythemia (ET) comes with uncontrolled elevation in platelet count. JAK2 mutation occurs only in 50% of ET. Bone marrow biopsy may be required for the diagnosis of ET. Both are clonal myeloproliferative neoplasms. ...Read more
By definition: All overgrowths of blood cells and the elements that form them are by definition cancer, since blood cells by their nature travel through the body. Given this, "ET" isn't even a life-shortener on the average, and I hope your illness proves manageable if it needs to be managed at all. ...Read more
Please let me know if there is any alternate treatment for essential thrombocythemia or high platelets?
There are alternative treatments for everything. However, the question is whether any are effective for ET. None are yet proven but a healthy diet, detoxification, exercise, herbs like turmeric, Japanese Knotweed & medical marijuana, stress reduction, homeopathy and acupuncture are worth exploring.
See http://medicalmarijuana. Com/medical-marijuana-treatments/E-T-
Work with an integrative doctor. ...Read more
By definition: Since the cells of the blood invade tissue, all tumors / clonal overgrowths are by definition cancers. Essential thrombocythemia can usually be kept at bay easily for decades. ...Read more
In the past year my ferritin has gone from 40 to 28. I am 42. No periods. Should I be concerned about this? I also have essential thrombocythemia
See your doctor: You need to be thoroughly evaluated by your doctor to see what's going on. ...Read more
It is a mild form of leukemia and may not cause symptoms. Some patients do develop complications. There is no cure through conventional treatments. In some cases bone marrow transplant may be warranted and can cure the disease. See this site for more info.
http://www. Mayoclinic. Org/diseases-conditions/thrombocythemia/basics/definition/con-20034386 ...Read more
My mom is 78 and was diagnosed w/essential thrombocythemia and is treatable with pills. Is this a form of cancer? I also here it as a disease.
Manageable cancer: ET, as it also called, is a disease with mutations in bone marrow cells leading to overproduction of platelets, packed bone marrow with abnormal platelet-producing cells, called megakaryocytes. The diagnosis is aided by testing for this mutation. Pills such as hydrea (hydroxyurea) and anagrelide control this overproduction. The disease is somewhat slow growing but can lead to leukemia and need hematology care. ...Read more
Discuss it with Dr: Fatigue is subjective? Age? How much fatigued? What is your hemoglobin (red cell), white cell and platelet counts? Hydroxyurea is used to reduce the platelet number and might reduce as a side effect the hemoglobin and/or the white cells. There are newer mediations which might be used. Go and discuss the problem with your oncologist, who knows you better than me! Do not hesitate to go and ask. ...Read more
I've been diagnosed with essential thrombocythemia and was wondering if it is safe to have a baby? I also get gestational diabetes, what are the risks?
It depends: This is a chronic condition, so I need full/complete history. Are you taking any medication for it? Many such cases are part of CML....so I need to see your CBC results and Chromosomal studies for the Philadelphia Chromosome (BCR/ABL Mutation test). If you are not taking any chemotherapy or targeted therapy like Imatinib, you can have a baby. But I need to see your platelet counts and CBC results. ...Read more
Could you with essential thrombocythemia (i.E. Too many platelets) donate platelets to a blood bank?
No: Would make sense in a way, no? But I seriously doubt the blood bank would allow a person with a blood disorder to donate any blood product. Thanks for your interest, though. ...Read more
Could someone with essential thrombocythemia (i.E. Too many platelets) donate platelets to a blood bank?
I've had a platelet count of more than 1000 for more than 6 months, have been taking aspirin daily for a month, could it be essential thrombocythemia?
Could be: You should consult a hematologist for proper evaluation. ...Read more
I'm a 34-year old with essential thrombocythemia. Since I am still low risk for blood clots, what are natural ways to lower my platelet count?
There are none: Essential thrombocythemia is a real disease and one for which the best treatment is to do nothing. Any "nature doctor" who offers you a non-evidence-based nostrum is doing less for you than someone who simply urges you not to treat a lab value. By the way, in the young, the thrombocytosis if iron deficiency can be mistaken for ET. Do you have a JAK2 mutation? Your physician is your best guide. ...Read more
I have essential thrombocythemia and now I'm pregnant, had gestational diabetes with my last 2 pregnancies and had a cerclage with both, any advice?
Low platelets: Thrombocytopenia has several potential causes. None are related to gestational diabetes. Severely low platelets can be related to bleeding episodes, You should be under the care of a Maternal Fetal Medicine specialist for several of the reasons noted, not a general obstetrician. ...Read more
Father is 50 & has essential thrombocythemia. His platelets are steady at 900, 000. His LDH is elevated. Only takes aspirin daily. Neg jak 2.This good?
Yes: Look at the person, not the numbers. I'm glad Dad is doing well. ...Read more
Yes: Essential thrombocytosis can be inherited (autosomal dominant). When inherited, it is called familial essential thrombocytosis. However, mutations can also occur later in life in a non-inherited pattern. ...Read more
Well-known: "Essential thrombocythemia" is a more familiar synonym. Mayo's is pretty good. It's usually quite mild and manageable. Http://www. Mayoclinic. Org/diseases-conditions/thrombocythemia/basics/definition/con-20034386 ...Read more
What to do if I have essential thrombocytosis. What food should I eat and what's not. I'm on an early stage.?
What do you suggest if I have essential thrombocytosis. What food should I eat and what's not. I'm on an early stage.?
None: The food usually dose not effect thrombocytosis. ...Read more
Educate yourself: If you're actually 32 years old, you're a little young for this diagnosis. Did you get genetic studies? You'll need to learn everything you can about it. Often the best treatment for bona fide essential thrombocythemia is to do nothing. There are medications that are helpful depending on your counts and whether it's giving you any problems. Your life expectancy isn't shortened by it. Keep learning ...Read more
Yes: Thrombocytosis will not affect your getting a tattoo. ...Read more
None: No herbal medicines have taken the place of hydrea (hydroxyurea) so far. Perhaps a new agent will show effectiveness in the future, but so far, nothing works as well as hydrea (hydroxyurea). ET at age 38 is not as dangerous as ET at age 60, but should still be checked by a hematologist, and treatment considered especially if platelet counts are high. ...Read more
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