Doctor insights on:
Essential Mixed Cryoglobulinemia
Cryoglobunliemia: May have no symptoms if cryo levels are low. Cryos can accumulate in the tissues, especially blood vessels. Excess bruising (purpura) on the skin is seen and sometimes a vasculitis (inflammation of the small blood vessels) - especially the lower extremities. Occassionally with very cold weather the fingers may get dark due to sludging. This could even cause damage of the finger tips. So keep warm! ...Read more
Is it possible for membranoproliferative glomerulonephritis to be caused by mixed cryoglobulinemia?
Yes: This would be indeed one condition capable of causing immune complex deposition in the glomeruli with associated pattern of membrano proliferative disease in renal histology. ...Read more
Membranoproliferative glomerulonephritis caused by mixed cryoglobulinemia? Big words, little meaning. Plz explain.
Autoimmune : You may have an internal autoimmune process that needs treatment. ...Read more
See details: Treatment depends of the area of the body involved and the severity of the involvement. If it is due to an underling disease such as myeloma or hepatitis c, it is often most effective to treat that disease first. Primary cryoglobulinemia is often treated with Prednisone and/or immunosuppressives and occasionally with plasma exchange. ...Read more
Insoluble proteins: Cryoglobulinemia is a condition in which a person's blood contains a large amount of a specific type of protein called cryoglobulins. This type of protein can clump up (become insoluble in blood) at reduced temperatures. These insoluble proteins can then block small blood vessels and cause clinical symptoms. Patients with multiple myeloma or hepatitis c can develop cryoglobulinemia. ...Read moreSee 1 more doctor answer
Help please, my doctors think I have cryoglobulinemia that is linked with amyloidosis. What is the cause of this?
3 broad : Cryoglobulinemia associated with amyloid is generally due to 1 of 3 causes: 1: an immune blood cell disorder (such as multiple myeloma) 2: an infection ( like hepatitis C) or 3: a "connective tissue" immune disorder such as lupus. Therapy is quite specific for each cause. You should talk with your MD to determine which type of specialist might be needed to clarify the exact cause and best Rx. ...Read more
In cryofibrinogenemia (not cryoglobulinemia), what is more likely---the condition incites an autoimmune reaction due to inflammation it causes, or an autoimmune process causes the cryofibrinogenemia?
Disease then CF.: Cryofibrinogenemia is an unusual finding that usually signifies an underlying disease process. It may be autoimmune, but is also associated with a host of other disease including malignancies, infections and medications. Sometimes it is a benign finding in an otherwise healthy person. ...Read moreSee 1 more doctor answer
See link: Here is a good overview to start with. Let us know if you have any follow up questions.... http://www.mayoclinic.org/diseases-conditions/thrombocytosis/basics/definition/con-20032674 ...Read more
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