Doctor insights on:
Erbitux Colon Cancer
Some response: Erbitux was one of the first monoclonals develoed. It targets epidermal growth Factor 1 and is used in metastatic colon Ca that has the wild mutated KRAS. The best response is like Herceptin where this epidermal growth factor 2 mAb requires added chemo. As such when Colon Ca is treated with Erbitux + chemo there is an improvement in response for a number of months. No cures have been seen. ...Read more
Final few yards of your intestine, between the terminal ileum (small bowell) and rectum. It squeezes water and solidifies waste to stool. It is subject to outpouching (divertics) polyps, and these can become cancers. The cells are abnormal, invade into the muscle and travel ...Read more
Colon cancer fluid filled in stomach can anyone tell survival period?2nd line chemo going on...Cetuximab n folfri
Confused???: I do not know what you mean by colon cancer fluid in stomach are you talking about ascites which is a free fluid in the abdomen or there is an abnormal connection because of the cancer between the colon and the stomach either way this is an advance cancer if surgery is not an option chemotherapy do not do much for colon cancer simply follow your doctor instruction and hope for the best. ...Read more
She is 59sept end 2013 we came to know tht she is having colon cancer stage 3.Then 6cchemos were given n in CT no improvement.Cetuximab goi survival?
Chemoresistance: In metstatic colorectal cancer combinations of chemotherapy utilized. Drug combos such as FOLFOX are employed. With a poor response, immunotherapy is added such as the VEGF receptor antibodies or those targeting epidermal growth factor receptors like Erbitux and Vectibix. If the standard or wild type Kras is present in mets, there is a fairly good response but neg activity in mutated Kras. ...Read moreSee 2 more doctor answers
Some effect: Single drug chemotherapy has failed to produce significant improvement in colorectal Ca. Combination chemo as in FOLFIRI with irinotecan has added about 5 month prolongation in survival and with immunotherapy using Avastin or Erbitux an additional 2-3 months can be observed. Chemo-Immuno with a mAb targeting the immunogenic protein appears to be giving further enhancement. ...Read more
Yes: While chemo like FOLFOX is transiently effective, more immunotherapeutic agents are showing good responses. Avastin a vascular endothelial growth factor inhibitor and Erbitux effecting epidermal growth factor 1 are working well as is the newer Neo-102 against the immunogenic protein. Chemo in conjuction with the biologics (immunochemo) is the best combo. ...Read more
If Xeloda and irinotecan alone not worked in colon cancer
Pt, that mean no chemotherapy will work?
Others may help: If certain chemos do not give the proper response, one can take a fresh bx and send it for chemosensitivity and cahemoresistant studies. This will tell which wont work and which have the potentail to help either as single agents or combinations of drugs including use of immune drugs including Avastin and Erbitux ...Read more
Hi doctors my brother 66 years old he had colon cancer stage 3 about 8 month ago he is done for chemical treatment cancer coming back 10 days ago what?
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