Doctor insights on:
My brother is hbe ag neg and antibody hbe ag positive. His viral load is 50000iu/ml. Alt is 33. U/s noramal. GE prescribed Entecavir 0.5mg.is it good?
Probable resistance: Entecavir is a nucleoside analog and has potent antiviral activity against hepatitis B virus (HBV) - the emergence of drug resistance is rare. If indeed his HBV viral load is 50,000 (I would repeat), then he has probably developed a mutation. The addition of adefovir may result in suppression, but only in about half of patients. Tenofovir may be warranted. See a hematologist for advice ...Read more
Many side effects: Combivir (lamivudine and zidovudine) has many side effects and some side effects like headache and neuropathy, anemia, neutropenia and thrombocytopenia, hepatic toxicity and lactic acidosis and loss of appetite and loss of weight to list a few can make you stop the cmbivir compond. ...Read more
Usually well-tolerated.: Heptovir is the generic name for lamivudine, a hepatitis B drug. For the most part, it is usually well-tolerated. Anyone could have side effects from the medications, however. Contact your doctor immediately if you have severe muscle pain or cramping, a sign of an allergic reaction, or severe abdominal pain. Good luck. ...Read more
2 versions 1 drug: They are the same drug except that the pegylation makes that drug longer acting, so it can be given less often. ...Read more
Many: The side effects are too many to list here but some of the more common ones (occur in >10% of patients) are fever, fatigue, headache, insomnia, depression, emotional lability, rash, nausea, diarrhea, weight loss, anemia, muscle aches, joint pains, flu-like syndrome and injection site reations. ...Read more
Yes: Adefovir does have HBV activity. I had poor experiences in using it as a HIV drug but the dose was higher for HIV so there was more toxicity ...Read more