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Doctor insights on: Enlarged Spleen With Mononucleosis

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Do all people with mono have enlarged spleen and lymph glands?

Do all people with mono have enlarged spleen and lymph glands?

Most: There are many variations in the clinical manifestations of mono and it may not cause any symptoms. Most people with clinical mono do have enlargements of lymph nodes, spleen and liver and these subside on their own with the natural resolution of the infection in an otherwise healthy person. ...Read more

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Dr. Heidi Fowler
393 doctors shared insights

Infectious Mononucleosis (Definition)

Mononucleosis is a viral disease caused by EB Epstein Barr virus. It can last 10-14 days even up to weeks and become chronic on occasion. A mono assay test can reveal if present and on an CBC can see nucleated or atypical lymphocytes. Sore throat, fatigue, fevers are the main symptoms. Treatment remains bedrest, fluids and Advil 400 mg po q 6 hrs until no symptoms occur. Reg ...Read more


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Difference between strep throat and mononucleosis?My simptoms:swollen and enlarged tonsils with white pockets,enlarged lymph nodes,no fever or fatigue

Difference between strep throat and mononucleosis?My simptoms:swollen and enlarged tonsils with white pockets,enlarged lymph nodes,no fever or fatigue

Get checked.: The most awful looking throats I see can be strep or mono. In strep, a person usually has a fairly high temperature and headache. In mono, you see fatigue as the major symptom. With no fever and no fatigue, I wonder if you have little pockets (crypts) in your tonsils that can trap food/debris and become irritated. Very enlarged tonsils can interfere with breathing - which is non-negotiable! ...Read more

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Chances lymphoma with no noticeable enlarged lymph nodes? CBC, CMP normal. CT normal- mildly enlarged spleen 13cm

Chances lymphoma with no noticeable enlarged lymph nodes? CBC, CMP normal. CT normal- mildly enlarged spleen 13cm

Very Low chance: It is reassuring that there aren't any enlarged lymph nodes, and you have a normalCBC. If there is a lymphoma, it is a very hard to detect one. And it is not causing any problems to the body. I would leave it alone. Get a check up maybe in 6 months- just labs, ldh and a physical exam or ultrasound for the spleen. Spleen sizes also vary quite a lot, but good to keep an eye on it. ...Read more

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Does an enlarged liver and spleen mean hepatitis?

Does an enlarged liver and spleen mean hepatitis?

Numerous: Not always. Multiple other reasons including blood disorder. Cirrhosis of the liver again that could be alcohol induced or other medical reason induced. Essentially multiple reasons key one is blood disorder. Seeing a hematologist is the key as underlying possibilities r numerous. ...Read more

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CTshows enlarged lymp nodes(Lower cervical/mediastinal and hiller); Also possible hepato-spleanomegaly-No discrete lesion.is this sarcoid or Lymphoma?

CTshows enlarged lymp nodes(Lower cervical/mediastinal and hiller); Also possible hepato-spleanomegaly-No discrete lesion.is this sarcoid or Lymphoma?

Mgt: The CT report and image may be uploaded during a virtual consult to better assist, but from your description many possible conditions are possible. EBUS biopsy is one way to determine the cause. A TB test and blood work may also be indicated. ...Read more

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Do lymph nodes swell with gall bladder disease?

Do lymph nodes swell with gall bladder disease?

Sometimes: This can sometimes occur, but it is not clinically significant unless there is gallbladder cancer. ...Read more

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Does Irritable bowel have a connection with enlarged lymph nodes?

Does Irritable bowel have a connection with  enlarged lymph nodes?

Probably not: Irritable bowel syndrome (IBS) or spastic colon is a symptom-based diagnosis characterized by chronic abdominal pain, discomfort and , bloating, It has no known organic cause but may be initiated after a GI iinfectious process or some interaction with the CNS. Abnormalities can exist with the GI flora and in rare instances enlarges mesenteric nodes but not regional cutaneous nodes. ...Read more

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Can pneumonia and antibiotics along with tylenol (acetaminophen) affect cbc and enlarged spleen and swollen lymph nodes? Doc thinks it can be anemic lymphoma

Can pneumonia and antibiotics along with tylenol (acetaminophen)  affect cbc and enlarged spleen and swollen lymph nodes? Doc thinks it can be anemic lymphoma

Many moving parts: The type of infectious organism will affect the cbc in various ways, usually causing an increase in neutrophils. Can affect lymphocytes and monocytes as well. The enlarged spleen may sequester immune cells or destroy red cells decreasing the numbers in the cbc. Depending on the antibiotic with Tylenol, (acetaminophen) either red cells, platelets or neutrophils can be destroyed (but rarely). (see comment) ...Read more

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Enlarged spleen, liver and increased numbers of \nsmall lymph nodes present what can this mean?

Enlarged spleen, liver and  increased numbers of \nsmall lymph nodes present what can this mean?

It can be many thing: There are many conditions which can cause enlarged liver, spleen and lymph nodes you need to have thorough history/physical exam, and blood test to find the cause. It may be anything like infectious mononucleosis, or another infectious process to lymphoma so have it checked asap. ...Read more

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Are lymph glands big with lymphoma?

Are lymph glands big with lymphoma?

Maybe: Enlarged lymph nodes (lns) may be associated with lymphoma, but the differential diagnosis (other causes) includes infection, inflammation, etc. Likewise, lymphoma often causes enlarged lns but not always. I have a recent patient with normal sized lns that are pet+ ("active") but with lymphoma in bone marrow. Lns may not be palpable and "hidden" inside body as well. ...Read more

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Can anemia cause enlarged lymph nodes?

Can anemia cause enlarged lymph nodes?

No: But there are many diseases which could be associated with both anemia and lymphadenopathy. ...Read more

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What could cause an atrophic spleen and enlarged thymus?

What could cause an atrophic spleen and enlarged thymus?

Many, maybe related: Spleen can be small either because it never grew (as baby/child) or because it was injured and became scarred. If problem started young enough, thymus can take over some of the spleen's work to compensate (so becomes bigger). Spleen filters old/damaged blood cells and helps produce new ones, filters out certain infections and has other immune functions; thymus is an important part of immune system. ...Read more

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Can a person feel enlarged spleen symptoms?

Can a person feel enlarged spleen symptoms?

Maybe: There are many conditions associated with an enlarged spleen. Depends on the underlying pathology, splenomegaly are sometimes discovered by accident in asymptomatic patients while other times associated with a multitude of symptoms such as malaise, abdominal swelling, pain, easy bruising... If in doubt, see your doctor. ...Read more

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Reactive submandibular lymph nodes can persist with mild piorrhea?

Reactive submandibular lymph nodes can persist with mild piorrhea?

Perhaps, but: Pperhaps, but periodontal disease which is a gram negative anaerobic rod bacterial infection, does not frequently drain to the lymph nodes. More frequently, mandibular infections from an unhealthy tooth will drain to the lymph nodes (and breast) on the same side. ...Read more

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What causes a enlarged spleen?

What causes a enlarged spleen?

Many causes : The spleen's job is to take older or damaged blood cells out of circulation. Diseases that cause abnormal or disrupted cells, like thallesemias and hemolytic anemia cause enlargement to compensate for the increased work. Congestion due to cirrhosis/portal hypertension cause enlargement by limiting blood flow out of the spleen. Tumors especially lymphoma can grow in the spleen as well. ...Read more

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Could drinking alcohol an enlarged spleen?

Could drinking alcohol an enlarged spleen?

Yes: Significant alcohol intake is associated with cirrhosis, portal hypertension, an enlarged spleen, and sophageal varices. ...Read more

Dr. Michael Ein
773 doctors shared insights

Mono (Definition)

Infectious mononucleosis, also known as mono, is a contagious illness caused by the Epstein-Barr virus. Symptoms include fever, fatigue, sore throat, enlarged lymph nodes, and enlarged spleen. It is spread via saliva, hence its ...Read more


Upper Abdomen (Definition)

Draw a transverse line through the umbilicus and the upper abdomen includes every part of the belly above this line and below the ...Read more