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Doctor insights on: Endep Tertiary Amine Tricyclic

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Which tcas is more potent for sciatica pain relief, amitriptyline(or nortriptyline), imipramine(or desipramine)?

Which tcas is more potent for sciatica pain relief, amitriptyline(or  nortriptyline), imipramine(or desipramine)?

TCA: Tca are classic for neuropathic pain - sciatica for example. Any of the ones u mentioned may be quite eefective - and cheap. They are not without side effects - dry mouth, constipation, sedation. Any of the ones u mentioned can be effective. I personally like amytryptilline - 10mg at night - as mentioned all will work. Additionally other meds such as lyrica, (pregabalin) neurontin, Cymbalta are options. ...Read more

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Dr. Heidi Fowler
326 doctors shared insights

Endep (Definition)

Endep is a tertiary amine tricyclic which is a kind of tricyclic type drug (serotonin-norepinephrine reuptake inhibiting ...Read more


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Is the antidepressant tofranil (imipramine) effective?

Is the antidepressant tofranil (imipramine) effective?

Yes: It is effective and sometimes works better than the new ones on the minus side it has anticholinergic side effects: dry mouth blurred vision constipation hot flashes etc. ...Read more

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Which causes asthenia after not taking; 1-Haloperidol 2-Carbamazepine 3-Lamotrigine 4-Biperiden 5-Methocarbamol 6-Quetiapine 7-Clomipramine?

Which causes asthenia after not taking; 1-Haloperidol  
2-Carbamazepine
3-Lamotrigine
4-Biperiden
5-Methocarbamol
6-Quetiapine
7-Clomipramine?

Asthenia : Weakness can be caused by induction of an adrenal deficiency in the setting of chronic steroid use ( withdrawal ) Any of the medications listed can produce perceived weakness in the setting of anxiety. ...Read more

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Is wellbutrin (bupropion) a dopamine agonist drug?

Is wellbutrin (bupropion) a dopamine agonist drug?

Mostly: Wellbutrin (bupropion) interferes with reuptake of dopamine&norepinephrine(noradrenaline)in the central nervous system, thereby leaving these neurotransmitters to sit longer&stronger in the synapse between communicating brain cells, which enhances dopamine&adrenaline activity at the cellular level. That can treat depression, feed pleasure to help sex&bypass tobacco, improve adhd&cognition, lower weight, etc. ...Read more

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Is lyrica (pregabalin) an ssri?

Is lyrica (pregabalin) an ssri?

No: Pregabalin is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures with or without secondary generalization in adults. It has also been found effective for generalized anxiety disorder and is (as of 2007) approved for this use in the european union. It was designed as a more potent successor to gabapentin. ...Read more

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Can periactin (cyproheptadine hydrochloride) (cyproheptadine) be useful in relieving serotonin induced migraine caused by an ssri? Periactin (cyproheptadine hydrochloride) has antiserotonin affinity. Head hurts..

Can periactin (cyproheptadine hydrochloride) (cyproheptadine) be useful in relieving serotonin induced migraine caused by an ssri? Periactin (cyproheptadine hydrochloride) has antiserotonin affinity. Head hurts..

Might be useful: Although Cyproheptadine is nominally an anti-histamine, it does have seratonin antagonistic effects, and, has been best used as a migraine preventative in years past. Since it is cheap, could try it, but likely should start low dose and aim for about 4mg every 6 hrs. May take about two weeks to decide success at the higher dose. ...Read more

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Is amitriptyline an maoi?

Is amitriptyline an maoi?

No: It is an antidepressant of the tricyclic group - very different. ...Read more

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150 mg. Elavil (amitriptyline) for 25 years switch to ssri with greatest sedative affect as elavil (amitriptyline) - which ssri would be best suited for me?

150 mg. Elavil (amitriptyline) for 25 years switch to ssri with greatest sedative affect as elavil (amitriptyline) - which ssri would be best suited for me?

Individual consult: To find something best suited to you, you need an individual re-assessment with your own doctor. There's no ssri as truly sedating as elavil (amitriptyline). In fact, this is partially why many ssri's are chosen over older antidepressants like Elavil (amitriptyline) anyway. People don't like to be drowsy in daytime. If you and your doctor are looking for sedation, an alternative (not an ssri) might be mirtazepine. ...Read more

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I'm considering taking elavil or tofranil (imipramine) for depression. Which is best?

I'm considering taking elavil or tofranil (imipramine) for depression. Which is best?

They're very similar: Elavil (amitriptyline) (amitripyline) and tofranil (imipramine) are both tricyclic antidepressants, an older category. While they are effective against depression, both can cause antihistamine-like effects e.g., sedation, dry mouth, dry eyes, constipation, and temporary trouble focusing vision. Elavil (amitriptyline) does this a little more, so tofranil may be better unless elavil's extra sedation helps. ...Read more

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Only noradrenergic antidepressant works for me, does inderal (propranolol) acts negative on noradrenergic effects of antidepressant ?At vasomotor centers.Regards.

Only noradrenergic antidepressant works for me, does inderal (propranolol) acts negative on noradrenergic effects of antidepressant ?At vasomotor centers.Regards.

Venlafaxine: It's not the vasomotor centers that are important in antidepressant response; it's the neuron synapses in the brain. Effexor (venlafaxine) inhibits reuptake of both serotonin and ne. Inderal can suppress some of the physical symptoms of anxiety (rapid heart rate, sweaty palms, tremulousness, etc). Some on chronic (not intermittent or "prn") Inderal have had more depression. Not everyone. You should be okay. ...Read more

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Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

TCA/SSRI: Both are, depending on what they are prescribed for. The difference is in tolerability & side-effects. ...Read more

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Is pamelor (nortriptyline) the safest trycyclic for cardiac patients?

Is pamelor (nortriptyline) the safest trycyclic for cardiac patients?

Others preferred: In gereneral tricyclic antidepressants including Pamelor (nortriptyline) are relatively less safe than other classes of antidepressants. This is especially true if "cardiac disease" means recent (within approximately 6 months) heart attack. Zoloft (sertraline, an ssri) may be relatively safer. Untreated depression contributes to worsened prognosis for certain types of heart disease. ...Read more

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Which is best? Paxil, (paroxetine) olanzapine, bupropion, or oxcarbazepine?

Which is best? Paxil, (paroxetine) olanzapine, bupropion, or oxcarbazepine?

Agree w Dr. Ali: Which is best for treating which condition?. Paxil is an SSRI antidepressant which is good for treatment of typical depressive sx 's & anxiety. Bupropion is a unique antidepressant which is good for seasonal affective disorder, atypical depression & smoking cessation. Oxcarbazepine is a mood stabilizer and olanzapine is an antipsychotic. You are asking us to compare apples & organges. ...Read more

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How effective are monoamine oxidase inhibitors (MAOIs) for treating depression?

How effective are monoamine oxidase inhibitors (MAOIs) for treating depression?

MAO i's.: Quite effective especially for resistant depression, however, strict dietary & other restrictions apply. ...Read more

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The depression medication, tofranil (imipramine) have side effects?

The depression medication, tofranil (imipramine) have side effects?

Yes, a tricyclic: Tofranil/imipramine is a tricyclic antidepressant that commonly causes dry mouth, sleepiness, nausea, upset stomach, constipation. It can also cause blurred vision, dizziness, and have sexual side effects. It is effective for depression and the common side effects tend to go away. ...Read more

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(Allegra, ortho tri-cyclen, Cymbalta)-GP prescribed. (Baclofen, Carb/Levo, & Adderall)-added by Neurologist. Interact. b/w meds to cause hypnic jerks?

(Allegra, ortho tri-cyclen, Cymbalta)-GP prescribed.
(Baclofen, Carb/Levo, & Adderall)-added by Neurologist. Interact. b/w meds to cause hypnic jerks?

Reconciliation: If different doctors all use electronic medical records, and they perform "medication reconciliation" at each visit so that they all know what doctor prescribed which medication, likelihood is high that the systems alerts of any potential problems with the medications. The Affordable Care Act (=Obamacare) mandates medication reconciliation. ...Read more

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Imipramine (tofranil) and desipramine (norpramin), what are these?

Imipramine (tofranil) and desipramine (norpramin), what are these?

Antidepressants: Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression ...Read more

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Is viibryd (vilazodone hydrochloride) often prescribed for anxiety?

Is viibryd (vilazodone hydrochloride) often prescribed for anxiety?

No, mostly.: But that's because it's a really new drug, so it's not prescribed "often" for anything! It IS an antidepressant, and all antidepressants are also used as antianxiety meds. This is because depression and anxiety are often considered to be flip sides of the same coin within psychiatry. If you are not comfortable with idea of the med, talk to your doc. Otherwise, maybe try it and see how it goes? ...Read more

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