Doctor insights on:
End Stages Of Multiple Myeloma
Doctors refuse to treat end stage multiple myeloma patient stating he is unfit. Can chemo still reverse his conditionpatient can't swallow pills, food?
I am sorry. If he is end stage, I would agree with his oncologist. It seems to me that he is really seriously ill.
Chemotherapy will not do him any benefit at this stage.
He should seek palliative care which will address all his
Symptoms including emotional, moral and spiritual support. My prayers are with him and you. ...Read more
I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more
My brother (51) is in the final stages of multiple myeloma and was told he will die of kidney failure. Blood tranfusions weekly. Timeline estimate?
Get extra support: Agree with prior answer that difficult to say. If not already involved ask for a palliative medicine specialist to work with your hematology-oncology team. They might be able to provide additional prognostication opinions as they monitor his progress and also provide additional support for the time that he has. ...Read more
Rarely: There are a few families where it appears hereditary. Having said this, there are families where more than one individual has the disease and the thought is that this may be due to an environmental cause. ...Read more
Just means multiple bone marrow tumors. A simple description like that does not take modern technology (though it would not be picked up early). Indeed, it has been known since ancient times. There have been a lot of discoveries along the way that explains what it is and how it arises. Here's an article on its history:
http://www. Ncbi. Nlm. Nih. Gov/pubmed/21509678 ...Read more
Blood/Urine/Imaging: Usually workup involves blood and urine tests (spep / upep - serum and urine protein electrophoresis). The preferred initial imaging study is the skeletal survey (x-ray of multiple sites of the body including skull, axial skeleton, and proximal long bones). Bony lesions are usually lytic. ...Read more
Multiple myeloma: Medial survival in myeloma many years ago was only 1-2 years. Nowadays, with many effective therapy such as lenalidomide, bortezomib, transplant -median survival has increased up to 7 years. Newer medications such as pomalidomide and cerfilzomib hopefully would be approved soon and more medication in pipelines are lining up - all of these would likely to increase the median survival longer. ...Read more
No simple answer: Multiple myeloma has been associated with ionizing radiation (atomic bomb level), herbicides, petroleum products, analin hair dyes, autoimmune disease but there is no clear cut association. There are a few families which show an inheritance pattern along with other lymphomas. ...Read more
The tests for Multiple myeloma include:: Albumin, Basic metabolic panel, Bone marrow biopsy, Complete blood count, Ionized calcium, Lactate dehydrogenase, MRI, Skeletal survey, C reactive protein, Protein electrophoresis, 24 hour urine protein electrophoresis, Free kappa lambda light chains, Beta 2 microglobulin. ...Read more
Depends...: This answer depends. That might not be as satisfying but is true. For a 90yo pt it is palliative -- keeping crab symptoms away with minimal discomfort fro m tx. A new study from dr. Campagnaro in ecog will evaluate. For most, "control" as a chronic disease. For some cure. If young, we like to obtain a "deep" response w/ complete response (cr) & now looking at minimal residual disease (mrd) by flow. ...Read more
MM and age: Mm is a disease of older adults. The median age at diagnosis is 66 years; only 10% and 2% of patients are younger than 50 and 40 years, respectively. ...Read more
Plasma cell cancer:
Multiple myeloma is a cancer of plasma cells (pcs). Pcs are the specialized b lymphocytes that produce antibodies. When there is a cancer or one (mono-) clone (= monoclonal, m) PC population they can product m-proteins. Symptoms include crab - hypercalcemia, renal (kidney) insufficiency, anemia, bone disease; also infection and pain.
More: http://www. Cancer. Net/cancer-types/multiple-myeloma. ...Read more
None: No symptoms by definition. Smoldering multiple myeloma (SMM) is asymptomatic. If it is "symptomatic" then it is (symptomatic) multiple myeloma (MM). A new International Myeloma Working Group definition of SMM and MM was just published...http://www. Thelancet. Com/journals/lanonc/article/PIIS1470-2045 (14)70442-5/abstract Ultra high risk SMM is now called MM. The trial E3A06 looks at SMM. ...Read more
No: It does not appear that we have a reliable cure for multiple myeloma. We can control it for a long period of time, and we continue to better understand treatment options and make new discoveries. Hopefully the day will come when we can cure multiple myeloma as well as we cure some leukemias and lymphomas. ...Read more
Blacks in US: Twice the incidence in african americans than caucasians. Some families have a higher incidence. ...Read more
Quite a bit: Of variability, but on average 5-7 years. ...Read more
None: If truly smoldering myeloma, there are no signs. If there are symptoms, then it may be myeloma. Hope this helps. ...Read more
Disease of adults:
Multiple myeloma is not a very common disease. It accounts for approximately 1% of all cancers
multiple myeloma is a disease of older adults. The median age at diagnosis is 66 years; only 10 and 2 % of patients are younger than 50 and 40 years, respectively. It is not a disease of teenager. ...Read more
Plasma cell cancer:
From the National Cancer Institute --> What You Need To Know About™ - What is Multiple #Myeloma - via @theNCI http://ow. Ly/o7CJR #mmsm and Snapshot: http://ow. Ly/ungNs
The IgG is the type of immunoglobulin heavy chain involved and can be used to follow the cancer in the blood. ...Read more
Treatment for multiple myeloma has improved markedly and drug treatment alone or drug treatment with auto or donor stem cell transplants can produce decades long remissions. See this site for more info.
http://www. Mayoclinic. Org/diseases-conditions/multiple-myeloma/basics/definition/con-20026607 ...Read more
Multiple Myeloma: While there is no defined "cure" for multiple myeloma, chemotherapy and autologous stem cell transplants have been shown to cause remission in many cases. With regard to cost, chemotherapy is expensive if paying cash and autologous stem cell transplant may cost over 100K, so it is important to check with insurance providers regarding this. ...Read more