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Doctor insights on: End Stage Glioblastoma Symptoms

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Dr. Jefferson Chen
90 doctors shared insights

Glioblastoma (Definition)

The unnatural, uninhibited overgrowth of certain supportive cells in the brain (not ...Read more


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What is the usual progression of symptoms for a parieto-occipital glioblastoma multiforme?

What is the usual progression of symptoms for a parieto-occipital glioblastoma multiforme?

Depends: If the tumor is on the left, the symptoms could include confusion while right sided tumors will only presents with numbness. Both sides can give visual symptoms but most patients don't present until they either have a seizure or are confused. ...Read more

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Is glioblastoma hereditary?

Is glioblastoma hereditary?

While there may: Be some tell-tale genetic fingerprints on some glioma, the bad one, gbm seems to be sporadic, with only radiation exposure as a risk. My father died of one 30 years ago. No other family members have had any brain tumors. ...Read more

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Where in the body does glioblastoma develop?

Where in the body does glioblastoma develop?

The brain.: Glioblastoma multiforme is the term for a very aggressive tumor that arises in the brain. It is usually treated by a combination of surgery, radiation therapy and cheomtherapy. Unfortunately, these tumors are very aggressive, and although treatment can slow their growth, they invariably recur. They are most commonly found in middle aged adults. ...Read more

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What is the definition or description of: glioblastoma?

A bad brain tumor.: Glioblastoma is the unnatural, uninhibited overgrowth of certain supportive cells in the brain (not the nerve cells themselves). Like other cancers, this can destroy good cells, often by pressure within the space of the skull. Unfortunately, it weaves its way between good brain cells and the limits of the growth usually cannot be known with certainty. That's why surgery alone may not be successful. ...Read more

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Why are glioblastomas so common and is there anything a person can do to reduce the chance of getting one ?

Why are glioblastomas so common and is there anything a person can do to reduce the chance of getting one ?

Uncommon cancer: You have misunderstood something you read. Glioblastomas are relatively uncommon cancers, with about 12,000 new cases each year in the entire US. Not exactly rare, but that's 20 times and 15 times less common than breast cancer and prostate cancer, respectively. Most other cancers also are more common than glio. There is no known prevention against glioblastoma, so good thing it's pretty rare! ...Read more

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What does the grade of a glioblastoma tumor indicate?

What does the grade of a glioblastoma tumor indicate?

Tumor grading: Grading of tumors is a way of "standardizing" the type of cancer, and thereby improving consistency of treatment between treating doctors/institutions. In gliomas as in other sites, a higher grade also implies a more aggressive tumor and potentially a poorer prognosis. However, some high grade tumors can be curable, whereas low grade tumors tend to linger but not respond to treatments. ...Read more

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What is the difference between glioblastoma and glioma?

What is the difference between glioblastoma and glioma?

GBM is agressive: Glioblastoma is a malignant tumor of the brain. It often invasive and agressive form of brain tumor whereas glioma is often a benign primary brain tumor. Glioblastoma has the tedency to spread locally or to other part of the brain. Treatment of glioblastoma includes combination of surgery, radiatoin with or without chemotherapy. Gliomas usually do not spread and are treated by resection alone. ...Read more

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What are the success stories of anyone surviving glioblastoma multiforme?

What are the success stories of anyone surviving glioblastoma multiforme?

Bad tumor: Cerebral tumors of this type are horrible events, and surgical excision may be useful for yrs. We now have some promising medications, and some newer techniques surgically to implant meds. Yet, the best we can do is prolong life for a while. Unfortunately, there are very few success stories. More understanding and research is needed. ...Read more

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In what way can we cure glioblastoma multiforme tumours?

In what way can we cure glioblastoma multiforme tumours?

Hard to say: Cure is a complicated word to use, but the chance of living five years with GBM has increased from 0.5% twelve years ago to 16% in the latest Optune study.

Who knows what the next twelve years will bring?

Joshua Garren, MD
Medical Director
Tulsa Brain Tumor Clinic
www.braintumorclinic.org ...Read more

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What is the average life span for babies with glioblastoma tumors?

What is the average life span for babies with glioblastoma tumors?

Variable: Glioblastoma is a specific type of tumor that usually presents in adults. It has a short median survival measured in months. Childhood brain tumors are of many different types and have a variable life span. ...Read more

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What is the best treatment for glioblastoma multiforme?

What is the best treatment for glioblastoma multiforme?

Multimodal treatment: The best treatment at this time for glioblastoma multiforme (gbm) is maximal safe surgical resection, followed by concurrent radiation and chemotherapy for the first 6 weeks. After that patients are usually placed on chemotherapy cycles for 6 months or until there is recurrence. At the time of recurrence additional surgery, different chemo, clinical trials or electric field therapy are options. ...Read more

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Glioblastoma multiforme grade 4 astrocytoma, what is this?

Nerve cell disorder: Glioblastoma is a condition where the cells in the brian, which stop dividing and migrating normally at around age 3, start dividing and migrating again.

It tends to spread within the brain, but does not invade or spread to other regions as a rule.

Joshua Garren, MD
Medical Director
Tulsa Brain Tumor Clinic
www.braintumorclinic.org ...Read more

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How effective is radiation therapy for treating glioblastoma?

How effective is radiation therapy for treating glioblastoma?

GBM and Radiation: GBM, or glioblastoma, is the highest grade brain tumor. It tends to grow rapidly. Unfortunately it is one of the CA we have trouble controlling. Even with high doses of radiation and chemotherapy the results are poor. On a good day we buy the pt time, on a bad day the tumor progresses while the pt is receiving treatment. ...Read more

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Glioblastoma multiforme, would chemoradation be a good treatment?

Glioblastoma multiforme, would chemoradation be a good treatment?

GBM: For most gbms, primary debulking surgery with craniotomy is being done by a neurosurgeon. After that upon recovery most patients undergo chemotherapy and radiation treatment together, usually using a chemo pill called temodar (temozolomide). After that temodar (temozolomide) is used as single agent therapy. Obviously some gliomas need different approach or clinical trial consideration, but this is the standard paradigm we use. ...Read more

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Please explain reasons why the term glioblastoma used to describe all brain tumors if all brain tumors aren't composed of glial?

Please explain reasons why the term glioblastoma used to describe all brain tumors if all brain tumors aren't composed of glial?

It is not.: Glioblastoma is not used to refer to all brain tumors - this refers to a single very specific tumor that arises from glial cells (astrocytes) and is the highest grade of Astrocytoma. There are numerous types of primary brain cancer , all with different terminology that generally reflects cell of origin (Astrocytoma, oligodendrogliomas, medulloblastoma. Meningioma, Ependymoma, and etc) ...Read more

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My dad has glioblastoma, what happens?

My dad has glioblastoma, what happens?

Treatment: These are typically treated aggressively surgery (if operable) followed by a combination of chemotherapy (temodar) and radiation, followed by more chemotherapy. Unfortunately these tumors have very bad prognoses. ...Read more

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How effective is radiosurgery for treating glioblastoma?

How effective is radiosurgery for treating glioblastoma?

Depends: This is difficult to answer. Glioblastoma is a very malignant tumor and very difficult to treat. The smaller the tumor the better the chances of "success " in treating the tumor with radiotherapy. Surgery also an option if again it is a small lesion. Unfortunately often times diagnosed at a late stage. ...Read more

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Is it possible to resect a glioblastoma multiforme?

Generally not: Glioblastoma is a high grade glial tumor. Glial tumors do not have distinct borders because glial cells have extensive cell projections and grow in a network ,rather than with discrete borders. Surgery can be performed to remove the bulk of tumor, but it is generally not possible to remove every tumor cell. Also, the location of the tumor often limits extent of surgery. ...Read more

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Is there any breakthrough treatment for glioblastoma anywhere?

Is there any breakthrough treatment for glioblastoma anywhere?

Not yet.: Please contact the american brain tumor association for current trials. If you mean "cure" the answer is unfortunately - not yet.
Here the link http://www.Abta.Org/. ...Read more

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Is it possible to completely resect a glioblastoma multiforme?

Gbm: Yes but location and neurological compromise in most cases didn't allow that. ...Read more

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How successful is surgery in curing malignant glioblastoma surgery?

How successful is surgery in curing malignant glioblastoma surgery?

Not good alone: The standard management for glioblastoma includes surgery followed by radiation and chemotherapy. Radiation and chemotherapy following surgery is well established to improve the overall survival of patients compared to radiation alone. ...Read more

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What are indications that glioblastoma cancer is in the final stages?

What are indications that glioblastoma cancer is in the final stages?

Losing performance: Gbm causes different signs depending on location, and growth on MRI signal progression. But decreasing ability to do daily activity, get out of bed, dress, walk, control bowel and bladder function are signs that time is short. Salvage treatment is used in able patients, and those willing to volunteer, but assess what benefit your patient gets and at what price. ...Read more

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What are the chances that my glioblastoma will come back after surgery?

What are the chances that my glioblastoma will come back after surgery?

Unfortunately likely: Glioblastoma is not a curable disease in most cases and is very likely to recur after surgery alone. It is strongly recommended that radiation and chemotherapy be administered in addition to surgery. ...Read more

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What is the success of avastin (bevacizumab) for treating glioblastoma? Does it work?

What is the success of avastin (bevacizumab) for treating glioblastoma? Does it work?

Marginal: It is primarily being used to treat recurrent malignant gliomas . The latest results with its use as a frontline treatment for malignant glioma show no real benefit over the current conventional regimen using radiation therapy and chemotherapy with temodar (temozolomide). ...Read more

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What is the cure for glioblastoma multiforme?

What is the cure for glioblastoma multiforme?

Incurable: Unfortunately, glioblastoma is incurable. It however can be controlled with surgery, chemotherapy and radiation therapy for sometime. Hopefully one day we can cure it but the science is not there yet. ...Read more

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Can constipation be a side effect of glioblastoma?

Not really ?: More likely, the opiod analgesics used for pain and headache cause condtioation. Sedentary life style can be a secondary cause. Discuss it with your physician. ...Read more

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Do you know are all cases of glioblastoma multiforme fatal?

Not all: There are survivors of gbm - but this is less than 5% at 5 years. I have 2 known survivors....But more than a hundred who have died. ...Read more