Doctor insights on:
Enbrel And Methotrexate
It's u as much as Rx: Again, this is a question for the treating specialist, most likely a rheumatologist. When treating a disorder like ra, there are a variety of medications that have been effective; as with everything else in medicine, no one size fits all, and the right drug or combo for each must be assessed over time by a specialist. ...Read moreSee 1 more doctor answer
Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more
Psoriasis+psor. Arthritis..Methotrexate 15mg for 2 mos. Already+humira weekly..Dr say stelera no good for arthr...Says remicade (infliximab) or enbrel maybe..Ok?
See below: The important side effects that have been most extensively related to tnf blockers include: lymphoma, infections including tuberculosis, congestive heart failure, demyelinating disease, a lupus-like syndrome, induction of auto-antibodies, injection site reactions, and systemic side effects. ...Read moreSee 1 more doctor answer
On arava (leflunomide) 20mg, enbrel 50mg weekly, methotrexate 25mg. Any other rheumatologist prescribed this for psoriasis/psor. Arthitis?I'm worried about my liver.
Follow laboratory: You are correct that liver problems are risk with this regimen. Your physician needs to be certain that you are followed closely and correctly. Your own responsibility is to refrain from alcohol, and be certain no additional medicines you take do not worsen this risk. If you are concerned you need to discuss this with your physician. There are other therapy choices available. ...Read more
Daughter on methotrexate and enbrel and indocin for JRA but hates getting shots every week. Could remicade (infliximab) be a better choice?
Humira (adalimumab) every 2 weeks stopped working&got a bad psoriasis flare-up...Now on humira (adalimumab) weekly w/15mg methotrexate but still have bad psoriasis.U recommend?
Psoriasis: While Humira is an excellent therapy for severe psoriasis, there are times when it stops working. Another option for you may be stelara (ustekinumab) which is also an injectable treatment which works a little differently than does Humira and is extremely effective in many patients. ...Read moreSee 1 more doctor answer
Rheumatoid arthritis for 7 yrs. On methotrexate & prednisone. Tried so many drugs (orencia, enbrel, (etanercept) humira...). Feeling defeated. What else can I try?
Other choices: Some older drugs such as Plaquenil may help, especially with fatigue. There are also newer drugs that act via different mechanisms such as actemra (tocilizumab). I assume the diagnosis of RA is definite. If not, retest other possibilities. An exercise program may be very beneficial, especially if you start slowly and build up with hurting yourself. Don't give up hope. You can get better. ...Read moreSee 1 more doctor answer
Enbrel (etanercept) 50 mg sq x 3 months for RA + psoriasis. Very little improvement. Any downside to increasing to enbrel (etanercept) 50 mg sq twice weekly? Mtx not tolerated.
No real downside: Tnf inhibitors like Enbrel don't increase in toxicity like other meds do. Increasing the dose to 50mg twice weekly is a good idea.But, if you don't also take methotrexate, for any reason, you will be more likely to develop antibodies against the Enbrel and neutralize it--causing it to lose most or all effectiveness.If increasing Enbrel does not work, consider another med like Humira or remicade (infliximab). ...Read moreSee 1 more doctor answer
Dx:ra. Enbrel (etanercept) not effective after 6 mo. Humira 2x mo prescribed. Liver can not tolerate mtx. What medication can replace mtx to make humira work best?
Yes: Cytoxan (cyclophosphamide) can be damaging both to eggs and sperm and therefore needs to be monitored closely by your rheumatologist and fertility doctor. Cytoxan (cyclophosphamide) is also considered class d in pregnancy suggesting risk of fetal harm. Long term Prednisone therapy has little effect on sperm production or ovulation. ...Read more
See details: Both are often very effective.Get a more detailed answer ›
Humira losing its effectiveness with RA. Unable to tolerate MTX or Plaquenil. Any Rheumotologists think Remicade (infliximab) would be a good option?
Can't hurt to try: I'm a family doctor, not a rheumatologist, but I do have RA patients who are on Remicaid who are responding very well with it. I don't know what that's worth to you, but I thought I would share. I think it's being used a lot more and does have FDA indication for RA. ...Read moreSee 1 more doctor answer