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Doctor insights on: Eliminate Circumscribed Scleroderma

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Dr. Mary Ellen Luchetti
12 doctors shared insights

Circumscribed Scleroderma (Definition)

Circumscribed scleroderma refers to localized scleroderma ("hard skin"). The body produces excess collagen which produces hardened skin. This can range from a small area of abnormal skin to a disfiguring skin lesion. Even though internal organs are not affected, the hard skin can attach itself to underlying muscle ...Read more


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What sort of disease is circumscribed scleroderma?

What sort of disease is circumscribed scleroderma?

Morphea: Limited scleroderma is called morphea and it is a inflammatory thickening of the skin which is thought to be a reaction to an infection. Early treatment with Minocycline can cause it to burn out leaving discoloration. Fractionated laser can be used on post morphea lesion to i prove color and texture. ...Read more

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Vacuolar interface dermatitis, tight superficl perivascular & periadnexial lymphocytic infiltrate, mild incr. In dermal mucin. No fungus.-rash biopsy.?

Vacuolar interface dermatitis, tight superficl perivascular & periadnexial lymphocytic infiltrate, mild incr. In dermal mucin. No fungus.-rash biopsy.?

Varied possibilities: These findings suggest several possible entities.Based on this description of biopsy findings diagnoses including connective tissue disease such as lupus erythematosus may be considered, as well as a drug reaction. However, the only way to accurately make a diagnosis is to correlate the biopsy findings with the clinical presentation and other symptoms a patient may be having. ...Read more

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What other conditions could 'focal dermal sclerosis' with telangiectasia on a skin biopsy indicate besides scleroderma?

What other conditions could 'focal dermal sclerosis' with telangiectasia on a skin biopsy indicate besides scleroderma?

Depends on clincial: This depends on your clinical status. It could be scleroderma but may not and may be something else. You need an evaluation ...Read more

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Skin biopsy result: superficial to mid dermal perivascular lymphocytic infilitrate with focal basal vacuolar changes.does thismean allergic vasculitis?

Skin biopsy result: superficial to mid dermal perivascular lymphocytic infilitrate with focal basal vacuolar changes.does thismean allergic vasculitis?

No: There is no involvement of the blood vessels themselves- thus not vasculitis by definition. This is a very common skin biopsy finding which has no diagnostic meaning other than ruling out a more serious condition. ...Read more

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What does all this mean..Heterogeneous glandular tissue w mild increased vascularity suggestive of thyroiditis/no focal lesion identified?

What does all this mean..Heterogeneous glandular tissue w mild increased vascularity suggestive of thyroiditis/no focal lesion identified?

Goiter/FNA: If this is your fna/fine needle aspirate result, then your doc will likely recommend medication and monitoring for your thyroid disease. ...Read more

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Help understand skin biopsy result: "There is a sparse perivascular lymphohistiocytic inflammatory infiltrate. CD117 highlights only a few scattered mast cells. Diagnosis: Mild superficial perivascular infiltrate." Anything of concern here?

Help understand skin biopsy result: "There is a sparse perivascular lymphohistiocytic inflammatory infiltrate. CD117 highlights only a few scattered mast cells. Diagnosis: Mild superficial perivascular infiltrate."  Anything of concern here?

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the findings listed in the report are non-specific and non-diagnostic. Do you have any symptoms? Why was the biopsy done? ...Read more

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High scl70, joint pain, fatigue,palmar erythema,telangiectasias,lung fibrosis,livedo reticularis,no hard skin! Can it be Scleroderma if no hard skin?

Rheumatologist: The answer would be yes. These symptoms and signs are consistent with an autoimmune/connective tissue disorder. A rheumatologist is best qualified to evaluate and treat you after ordering appropriate tests. ...Read more

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Lichen simplex chronicus pathology was done in 2008 saying;biopsy of skin on chin show hyperkeratosis without fungal infestation, spongiotic changes of the epidermis and a superficial perivascular chronic inflammatory cell infiltrate composed of primari

Lichen simplex chronicus pathology was done in 2008 saying;biopsy of  skin on chin show hyperkeratosis without fungal infestation, spongiotic changes of the epidermis and a superficial perivascular chronic inflammatory  cell infiltrate composed of primari

This : This is very challenging without a clinical examination. This could be lichen simplex chronicus, prurigo nodularis, or other possibilities. Certainly i would get it looked at to be sure so i would recommend you see a dermatologist to further evaluate the area. There are many treatment options to helps these conditions. I hope that helps! ...Read more

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Pigmented lesion ..Back...Biopsy sheets dermoepidermal junction nests pigmented bland looking round cells &nuclei.......Whats diagnosis plz?

Pigmented lesion ..Back...Biopsy sheets dermoepidermal junction  nests pigmented bland looking round cells &nuclei.......Whats diagnosis plz?

Sounds benign: This description sounds like a benign mole or what a pathologist would call a junctional nevus. There should be a final diagnosis on the report in addition to the description. Doesn't sound worrisome or atypical to me. ...Read more

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Derm biopsy report: mild vacuolar dermatitis with scattered papillary dermal interstitial eosinophils and perivascular lymphocytes. What does it mean?

Derm biopsy report: mild vacuolar dermatitis with scattered papillary dermal
interstitial eosinophils and perivascular lymphocytes. What does it mean?

Biopsy report: You need to discuss this with the person who did the biopsy and ordered the report. They are in the best position to interpret it. We don't even know where the biopsy was from. ...Read more

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What does this mean: urticarial change including deep dermal fibrosis with underlying morphea and telangiectasia with melanin incontinence?

What does this mean: urticarial change including deep dermal fibrosis with underlying morphea and telangiectasia with melanin incontinence?

Talk to derm: From what i can see, the skin rash is from hives and the scarring from scratching. I have never heard of the term melanin incontinence so I have no idea what it means. The best thing is for you to discuss this with the derm doctor who did the biopsy. ...Read more

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What is "skin thickening" or "hardening" in scleroderma patients?

What is "skin thickening" or "hardening" in scleroderma patients?

Scleroderma: Scleroderma, or systemic sclerosis, is a chronic connective tissue disease generally classified as one of the autoimmune rheumatic diseases. The word “scleroderma” comes from two greek words: “sclero” meaning hard, and “derma” meaning skin. Hardening of the skin is one of the most visible manifestations of the disease. ...Read more

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Ana positive 1:80 homogeneous pattern & 1:160 centromere pattern...Additional tests needed or just by centromere pattern crest & scleroderma r present?

Almost certain: Positive anti-centromere antibodies would indicate the presence of scleroderma/crest, better if anti–scl-70 antibodies also present, plus clinical symptoms and signs. ...Read more

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Biopsy from terminal ileum during colonoscopy showed "focal ileitis with superficial erosion. No granulomas, no specific cause identified" ?

Biopsy from terminal ileum during colonoscopy showed "focal ileitis with superficial erosion. No granulomas, no specific cause identified" ?

Forerunner: Of worse to come unless the dietary cause is eliminated. I have always stopped my patients from taking milk and milk products when they have ulcerative colitis. Try it! its cheap. Also check out your diet in general. Apart from milk, restrict it to "god made" foods. ...Read more

Dr. Pierre Moeser
184 doctors shared insights

Scleroderma (Definition)

An autoimmune disease in which there is excessive thickening of the connective tissues. This can cause skin tightening, rash, difficulty swallowing, and in severe cases affect ...Read more


Dr. Neigatha Graney
142 doctors shared insights

Dermatosclerosis (Definition)

Dermatosclerosis = scleroderma = autoimmune disease affecting connective tissue & blood vessels. It causes skin to thicken asymmetrically due to deposits of fibrous connective ...Read more