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Doctor insights on: Eligard Gnrh Stimulator

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Dr. Walter Husar
25 doctors shared insights

Gnrh (Definition)

Gnrh= gonadotropin releasing hormone is a hormone made in the hypothalamus of the brain involved with release of ...Read more


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Gonadotropin-releasing hormone (gnrh) stimulates what?

Gonadotropin-releasing hormone (gnrh) stimulates what?

FSH,LH: Gnrh stimulates follicle stimulating hormone & luteinizing hormone which stimulates the ovary to produce estrogen and Progesterone which stimulates ovulation which causes increased Progesterone which causes secretory endometrium which prepares the endometrium to allow implantation of a fertilized egg. If no fertilized egg, Progesterone falls which stimulates gnrh to again rise & the cycle repeats. ...Read more

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How does lupron (leuprolide) depot work for endometriosis?

How does lupron (leuprolide) depot work for endometriosis?

In the brain: Receptors in the brain get saturated to a that point the pulses of gnrh cannot stimulate the ovarian production of estrogen. ...Read more

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Has anyone used synarel (nafarelin) to treat endometriosis?

Has anyone used synarel (nafarelin) to treat endometriosis?

Long time: Yes, i used it to treat patients occasionally in the early-mid 1990s, as did many other specialists. It was fairly effective but cumbersome to use. I've not used it in many years, and it's overall popularity has faded significantly. ...Read more

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Can a zoladex (goserelin) 3.6mg implant induce artificial menopause?

Can a zoladex (goserelin) 3.6mg implant induce artificial menopause?

Chemical menopause: Zoladex (goserelin) 3.6 mg implanted every 28 days will put a woman chemically into menopause and make her menstrual periods stop. In fact, about 2 weeks after the first implant there will be a hormone withdrawal bleeding, after the next implant there will be no bleeding, if the medication works perfectly. ...Read more

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Why don't doctors prescribe aromatase inhibitors in FTM testosterone replacement therapy?

Why don't doctors prescribe aromatase inhibitors in FTM testosterone replacement therapy?

Aromatase: FTM requires two things: 1: I do not take care of such patients unless I am notified by a Psychologist who is taking care of the patient. 2: I do not see any indication for aromatase inhibitors to be given in addition to testosterone. I have been fortunate to have reasonable success with FTM and MTF. ...Read more

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What problems are there switching from degarelix to eligard (leuprolide)?

What  problems  are  there switching  from  degarelix to  eligard (leuprolide)?

Not many problems: One problem may be insurance coverage unfortunately but overall symptoms between the two are likely to be similar. Studies have shown perhaps increased effectiveness of degarelix vs Eligard (leuprolide) when treating prostate cancer. ...Read more

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Evista (raloxifene) estrogen receptor for uterine cancer?

Evista (raloxifene) estrogen receptor for uterine cancer?

Unclear Question?: These are somewhat unrelated questions which makes it difficult for me to address your question. Evista (raloxifene) is not used for treating cancer...It is sued for treatment/prevention of osteoporosis. Estrogen receptors are specialised protein receptors found in breast cancer.Uterine cancer has little bearing on either of the two references you have listed. ...Read more

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What are the medical uses of lupron (leuprolide) depot injections?

What are the medical uses of lupron (leuprolide) depot injections?

Endometriosis ...: Depo-lupron monthly or 3-month injections are used for women with endometriosis or chronic pelvic pain, men with prostate cancer, and children with puberty too young. It may be used to shrink uterine fibroids before surgery. Depo-lupron is used in fertility treatment to prevent ovulation in frozen embryo transfer cycles & egg donor recipients, and can be used before ivf in women with endometriosis. ...Read more

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Pain from having hormone injections(gnrh agonist)?

Pain from having hormone injections(gnrh agonist)?

Unlikely: Generally no, not pain unless you mean pain at the injection site. ...Read more

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Gonadotropin-releasing hormone (gnrh) stimulates the production what?

Good question: Gnrh would seem by its name to help release gonadotropin. And if used in a certain fashion it could cause the release of gonadotropins (lh, fsh). However when given in a shot and having a sustained effect on the pituitary, it actually suppresses the release of lh and fsh. And this aspect of the medication can be used to help in many situations. ...Read more

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Do you control parathyroid hormone secretion using casr antagonist?

Do you control parathyroid hormone secretion using casr antagonist?

Her how it works: The g protein-coupled, seven-pass transmembrane molecule present in the parathyroid gland and kidney controls calcium homeostasis by releasing parathyroid hormone (pth). Manipulating calcium-sensing receptor (casr) using small-molecule allosteric modulators can affect PTH secretion. ...Read more

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Lupron (leuprolide) depot not helping. What are some alternatives?

Lupron (leuprolide) depot not helping. What are some alternatives?

Assume Pelvic Pain: ? Diagnosis endometriosis and pain. If Lupron (leuprolide) is not helping, the pain is either coming from very severe endo, or from another source. A common associated pain is from the inguinal region and is often associated with endo. Surgery to correct this relieves pain in more than 80%. There are other potential causes of pain that should be evaluated. Seek pelvic pain/endo specialist for more help. ...Read more

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Is lupron (leuprolide) an effective treatment for endometriosis?

Is lupron (leuprolide) an effective treatment for endometriosis?

Yes: There are many different treatments available for the treatment of endometriosis. Lupron (leuprolide) is a medicine that decrteases estrogen levels and causes endometriosis to shrink away in most woman. Lupron (leuprolide) is used to treat endometriosis pain and endometriosis lesions/endometriomas. It should not be used long term to treat infertility associated with endometriosis-consider other options such as surgery. ...Read more

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63 yrs had prostatectomy @ 55 on lupron (leuprolide) would caverject help me?

63 yrs had prostatectomy @ 55 on lupron (leuprolide) would caverject help me?

Possibly: Erectile dysfunction following prostate cancer surgery is due to multiple factors including damage to nerves, blood vessel dysfunction, etc. Ed can be worsened if hormone ablation is required for recurrent disease also leading to low libido. If you have failed oral therapy, vacuum device, then intracavernosal injection therapy (caverject) may help. See your urologist to discuss further. ...Read more

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Lupron (leuprolide) withdrawal symptoms for male?

Lupron (leuprolide) withdrawal symptoms for male?

Not aware of any: Generally, stopping Lupron (leuprolide) just allows the whole hypothalamic-pituitary-gonadal axis to start getting back to normal, with gradual increases in both testosterone and estrogen as the Lupron (leuprolide) wears off. In some people who have been on multiple courses of lupron, (leuprolide) or have been on it for a long time, there may not be recovery, and the low testosterone and estrogen may be permanent. ...Read more

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Why do patients taking gnrh-a lose bone?

Why do patients taking gnrh-a lose bone?

GnRH hormones: While normally gnrh stimulates sex hormones, it achieves this only when it is secreted in bursts by the hypothalamus. When given in injections, it circulates continuously and it suppresses the hormones that in turn stimulate the ovary in women and the testes in men. As a consequence, there is a lack of sex hormones (estradiol in women, testosterone in men, leading to bone loss as in menopause. ...Read more

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What problems are there switching from degarelix to eligard (leuprolide)?

Not many problems: One problem may be insurance coverage unfortunately but overall symptoms between the two are likely to be similar. Studies have shown perhaps increased effectiveness of degarelix vs Eligard (leuprolide) when treating prostate cancer. ...Read more

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I was told that I had a slight decrease in my bone density while on gnrh-a. Can you explain this?

I was told that I had a slight decrease in my bone density while on gnrh-a. Can you explain this?

Low estrogen: Estrogen is important for building bone and maintaining bone density. When one is on gnrha therapy (lupron) estrogen concentrations are low, and therefore bone is lost. Fortunately, after stopping therapy, bone density tends to return to normal. ...Read more

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Why do FSH levels rise around day 14 of the cycle? Is it just because of the higher GnRH that cause the LH surge?

Why do FSH levels rise around day 14 of the cycle?  Is it just because of the higher GnRH that cause the LH surge?

You asked...: FSH rises because 1) it induces expression of its own receptor and 2) it stimulates E2 production, which also induces expression of more FSH receptors. GnRH is not "higher" or lower, GnRH is pulsatile: the frequency of the pulses is as important (or more) than the pulse amplitude. If this unclear, I suggest consulting an endocrinology text, there is no short version. ...Read more

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Gonadotropin-releasing hormone (gnrh) stimulates what?

FSH,LH: Gnrh stimulates follicle stimulating hormone & luteinizing hormone which stimulates the ovary to produce estrogen and Progesterone which stimulates ovulation which causes increased Progesterone which causes secretory endometrium which prepares the endometrium to allow implantation of a fertilized egg. If no fertilized egg, Progesterone falls which stimulates gnrh to again rise & the cycle repeats. ...Read more

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What is the definition or description of: gnrh?

What is the definition or description of: gnrh?

Pituitary hormone: Gnrh= gonadotropin releasing hormone is a hormone made in the hypothalamus of the brain involved with release of hormones involved with ovulation. ...Read more

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Whats role of gnrh in ovulation?

Whats role of gnrh in ovulation?

GnRH: Fsh and lh stimulated which in turn stimulates production of estrogen and progesteron in proper cycle. ...Read more

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What hormones stimulate the release of gnrh?

What hormones stimulate the release of gnrh?

Insulin: GnRH is stimulated by an increase in insulin (as can be seen in PCOS). An increase in prolactin causes a decrease in GnRH. GnRH is low in early childhood, then is activated in puberty, and has a pulsatile release for normal reproductive function. What exactly initiates puberty is not completely known with biological and environmental factors playing a role. ...Read more

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Do gnrh agonists have side effects?

Do gnrh agonists have side effects?

Absolutely: These drugs can cause a temporary medical menopausal state with all of the associated symptoms, ie, hotflashes, vaginal dryness, sleep disturbances, mood swings, etc. ...Read more

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Can an increase in testosterone decrease gnrh release?

Yes: Testosterone (from the testicles) and gnrh (from the hypothalamus) are connected by a feedback mechanism much like the thermostat in one's house. When testosterone levels rise for whatever reason, the hypothalamus decreases its release of gnrh to help bring t back to normal levels and vice versa. ...Read more

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Pain from having hormone injections(gnrh agonist)?

Unlikely: Generally no, not pain unless you mean pain at the injection site. ...Read more

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Gonadotropin-releasing hormone (gnrh) helps make you taller?

No: It does not make you smaller. It's a pituitary hormone that control the release of sex hormone (estrogen, testosterone...). ...Read more

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Is it true that gnrh agonists are good treatments for endometriosis?

Is it true that gnrh agonists are good treatments for endometriosis?

Temporary Relief?: First, one needs to be sure of the diagnosis. It is a surgical diagnosis. Second, these medications create a temporary menopause with numerous side effects including bone loss. Add back hormones may help. That stated, these medications allow for the shrinking of the lesions but they are not removed. Within three months of stopping the medication, the lesions are back with symptoms to follow. ...Read more

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Gonadotropin-releasing hormone (gnrh) stimulates the production what?

Good question: Gnrh would seem by its name to help release gonadotropin. And if used in a certain fashion it could cause the release of gonadotropins (lh, fsh). However when given in a shot and having a sustained effect on the pituitary, it actually suppresses the release of lh and fsh. And this aspect of the medication can be used to help in many situations. ...Read more

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I am taking testosterone suppressant therapy.(eligard). What can allow me to have erections?

ED: There are three drugs: viagra, Levitra (vardenafil) and Cialis that your physician can prescribe. There is also trimix (pge-1) that can be injected into the body of the penis; muse is a suppository that is inserted in the urethra (pge-1); vacuum erection devise(ved). Insertion of a semirigid or inflatable prosthesis could be considered if everything else fails but it requires surgery. Good luck. ...Read more

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What is gnrh hormone?

Complicated: Gnrh stands for gonadotropin releasing hornone. It's a neurohormone produced in the hypothalamus (part of the brain). Its release controls the production/release of 2 pituitary hormones called luteinizing hormone (lh) and follicle stimulating hormone (fsh) which in turn regulate and affect your ovary/menstrual periods or in men sperm and testosterone production. ...Read more

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Can you tell me about hormones: gnrh surge--> lh?

Normal: I am not sure what you are asking, but GNRH is a hormone produced by the hypothalamus. It is made in a pulsatile manner normally. This acts on the pituitary gland to cause the release of LH, also in a pulsatile manner. Taking large amounts of GNRH analogs (such as Lupron) initially causes release of LH, but then suppresses further release (thereby turning off testosterone or estrogen production) ...Read more

Dr. Andrew Seibert
159 doctors shared insights

Leuprolide Acetate (Definition)

Leuprolide acetate is a GnRH stimulator which is a kind of women's ...Read more


Dr. Jeffrey Stevens
9 doctors shared insights

Eligard (Definition)

Eligard is a GnRH stimulator which is a kind of women's ...Read more