Top
30
Doctor insights on: Elevated Total Protein And Globulin

Share

Protein (Definition)

Proteins are large molecules made up of a smaller class of molecules called amino acids. Proteins play an enormous role in the function of our bodies including enzymes, messengers, replicating dna, ...Read more


2

2
Testing for AL amyloid. SPEP shows no M-spike but mildly elevated total protein & A/G ratio (2.7) due to high albumin. Globulins well within normal range. Worrisome? Serum/urine IFE &marrow biopsy ok, but elevated free K/L ratio due to low lambda.

Testing for AL amyloid. SPEP shows no M-spike but mildly elevated total protein & A/G ratio (2.7) due to high albumin. Globulins well within normal range. Worrisome? Serum/urine IFE &marrow biopsy ok, but elevated free K/L ratio due to low lambda.

OK: This is a thorough work up, the K/L ratio would not concern me in this instance unless either of the components were high, In that case I would check a bone marrow, which you have already confirmed as normal ...Read more

3

3
Why are my total protein and globulin levels high?

Why are my total protein and globulin levels high?

Need more info: It is likely that your gamma globulins are increased causing increase in total proteins. There are many causes of elevated gamma globulins such as, inflammation, liver disease, especially cirrhosis, bone marrow diseases and autoimmune disorders, chronic infections including AIDS, See this site for more info and consult your doctor.
http://www. Nlm. Nih. Gov/medlineplus/ency/article/003544.htm ...Read more

4

4
My monocytes and eosinophils high and my neutrophils low. What does this mean? Also why is my total protein and globulin high?

My monocytes and eosinophils high and my neutrophils low. What does this mean? Also why is my total protein and globulin high?

Need values: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, it would have helped to have the actual values rather your interpretation of high and low. ...Read more

5

5
What do you suggest if my monocytes and eosinophils high and my neutrophils low. Also why is my total protein and globulin high?

Need for evaluation: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your test results suggest chronic inflammation, but it is not feasible to be specific without more history, physical examination, maybe imaging studies and additional tests. Cleveland clinic would be a good place to seek care. ...Read more

6

6
My total protein level is normal, albumin is also normal but globulin is 3.7. Pls tell is this something to worry about?

My total protein level is normal, albumin is also normal but globulin is 3.7. Pls tell is this something to worry about?

Depends on why...: Lab values are just numbers. Their meaning depends on why the tests were done and what is happening to the person. If there is nothing wrong with the person, then values inside the normal range, or just a little outside the normal range, are usually not worrisome. The 3.7 is close to the normal range, but it is just a number without knowing the patient's story. ...Read more

9

9
Blood results showing total protein at 87g/l and globulin at 39g/l with a A/G ratio of 1.2, should I seek further test. Cant afford to pay right now?

We normally see: Results for total protein between 6 and 8.3 grams/deciliter for 87 g/l would be 8.7, I believe. And globulin at 39 g/l would be 3.9 g/dl: both are a little high. Causes of high protein are inflammation, infections or bone marrow disorder. You don't give me the albumin, the "A" in the A/G ratio. Your ratio is a little high (normal <1). While not urgent, I think this deserves further follow-up. ...Read more

11

11
Total protein 7.9 albumin 3.7 globulin 4.2. And albumin/globulin ratio is 0.9. Is this concerning?

Total protein 7.9 albumin 3.7 globulin 4.2. And albumin/globulin ratio is 0.9. Is this concerning?

Generically not prob: Overall this is not a problem. Typically you want your Albumin a little higher so it would be helpful to know if you are dieting or have a good amount of protein in your meals. Ratio should be about 1. ...Read more

12

12
Is 1.7 globulin level (ref range 1.9-3.7) a reason to be concerned? Total protein is 6.3 and albumin 4.6 are normal.

Is 1.7 globulin level (ref range 1.9-3.7) a reason to be concerned? Total protein is 6.3 and albumin 4.6 are normal.

Not by itself: Much more important than the value itself, which is borderline low would be 1. The reason for why you had the test, symptoms versus regular checkup and 2. The trend, is there a previous value to compare with? Otherwise would not worry. Best would be to contact the physician who ordered the test. ...Read more

13

13
Dr. Said my blood work was fine but globulin was high at4.4 (norm 2.0-4.0)A/G ratio was low at. 9 (norm 1.0-2.4)Total protein and albumin normal. This ok?

Dr. Said my blood work was fine but globulin was high at4.4 (norm 2.0-4.0)A/G ratio was low at. 9 (norm 1.0-2.4)Total protein and albumin normal. This ok?

Repeat the test.: Your albumin/globulin ratio will be low with a normal albumin and high globulin, since it is simple a ratio of tests. Higher globulin may mean a chronic inflammatory or infectious disease or condition, leukemia or other bone marrow disease, an autoimmune disease such as lupus or rheumatoid arthritis, liver or kidney disease. In your case, the globulin may be elevated due to a past cold or virus. ...Read more

14

14
High Hs-CRP, high AGAP, high total protein, globulin and auto basophil?

Means nothing alone: Please forgive my frankness. This mishmash of lab results is meaningless apart from your history and physical exam. Reference ranges for labs are set so that a few percent of healthies fall outside on either end. If you feel well, ignore them. The high hs-CRP may be a heads-up that you've got more atherosclerosis than you think. If you feel well, ignore the rest. ...Read more

15

15
High globulin and total protein levels. Google says 'concerning'. Doctor isn't worried. Why?

High globulin and total protein levels. Google says 'concerning'. Doctor isn't worried. Why?

Tx the pt, not the #: The levels you describe, can't be meaningfully interpreted since there's no clinical context (Why were the tests done? Were you ill when the tests were done? Are you feeling better?) "Google's statement is too general- abnormal levels can be "concerning" but doesn't have your doc's luxury of knowing your specific event. If you are still worried, Go ahead and ask your doctor for clarification. ...Read more

16

16
My physical bloodwork came back with a 2.4 albumin/globulin ratio. My total protein was 6.4. Is this something I should have checked into further?

My physical bloodwork came back with a 2.4 albumin/globulin ratio. My total protein was 6.4. Is this something I should have checked into further?

Ignore it: If your other labs are unremarkable and you feel well, this kind of inquiry is not likely to provide any useful information. Many people do not understand that lab reference ranges are set up so that several percent of healthy people fall outside. Best wishes. ...Read more

19

19
Total protein 8.3, serum albumin 4.2, serum globulin 3.8, albumin globulin ratio 1.2. Is this abnormal?

Abnormal labs: It would be helpful that for the labs mentioned above. If you. Can find the normal range or reference range and list it than our answer can be more educated and helpful. The reference range does vary from one lab to another. ...Read more

20

20
Total protein 8.2 g/dl, range 6 - 8 g/dl albumin 4.9, 3.5 - 4.9, globulin 3.3, 2.3 - 3.7.i was dehydrated and had 7 mosquito bites. Should I worry?

Total protein 8.2 g/dl, range 6 - 8 g/dl albumin 4.9, 3.5 - 4.9, globulin 3.3, 2.3 - 3.7.i was dehydrated and had 7 mosquito bites. Should I worry?

Nah: Those numbers seem fine; I would be more interested in your electrolytes if you were dehydrated. However, if you've already been treated, no worries! ...Read more

21

21
Extremely fatigue ran blood test all in normal range except total protein 8.7, globulin slightly high, albumin boarder lined, is that why I'm tired?

Extremely fatigue ran blood test all in normal range except total protein 8.7, globulin slightly high, albumin boarder lined, is that why I'm tired?

Fatigue: You may have some type of chronic fatigue syndrome, and there are many possibilities. The blood test does not diagnosis the problem. You need to continue to see your doctor for more evaluations to determine the cause of your fatigue and treat you as necessary. ...Read more

22

22
Healthy adult female. Total protein 88g/l (60-82), globulin 42g/l (20-39). A/g ratio, liver enzymes, rft normal. 2 similar results over 6months. Why?

Lab data: This is meaningless without knowing your symptoms and why the tests were run. Have no idea what rft is, but if you can define it, please rephrase the question. Generally, laboratory values without clinical relevance are impossible to interpret. Good luck. ...Read more

23

23
Had panel due to fatigue and aches. All is well except Total Protein 8.4 (H) ALB 4.7 (H) Globulin 3.7 (H) A/G ratio - 1.27. Possible Myeloma? Normal?

Had panel due to fatigue and aches. All is well except Total Protein 8.4 (H) ALB 4.7 (H) Globulin 3.7 (H) A/G ratio - 1.27. Possible Myeloma? Normal?

Myeloma quite a leap: The globulins are not significantly outpacing the normal proteins (albumin) this would go AGAINST myeloma. And. Proteins can be elevated from concentrated blood (dehydration) would need other measures to assess that. ...Read more

25

25
CMP & CBC are normal except Globulin is 4.2 & Total Protein is 8.4? I am freaking out w/ Dr. Google. 33 years old.....myeloma?

CMP & CBC are normal except Globulin is 4.2 & Total Protein is 8.4? I am freaking out w/ Dr. Google. 33 years old.....myeloma?

Unlikely: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, it is unlikely that you have myeloma. There are other causes of elevated globulins. However it is not feasible to provide a meaningful opinion without physical examination and additional tests. Consult your doctor. ...Read more

26

26
Can having, lets say, 7 mosquito bites (not big ones) at the time of a cmp test that checks for total protein and albumin, increase globulin levels?

Could be normal: I need to see the type or types of globulin that are elevated, each type, if elevated has a different group of diagnoses associated with it. If you only had one type tested, you need to get a set of quantitative immunoglobulins measured, and reviewed with an ID doctor or your internist. Exposure to mosquitoes is usually not a cause for worry, but if you are febrile or have symptoms, see a doctor ...Read more

28

28
Is there any great significance in a lab test result with Urea 11.9 mmol/L, Total Protein, 61 g/L, Globulin 20 g/L? Everything else is normal This is the first sign of abnormality; follow up tests not yet done Non med diabetic but excellent control

Is there any great significance in a lab test result with Urea 11.9 mmol/L, Total Protein, 61 g/L, Globulin 20 g/L? Everything else is normal This is the first sign of abnormality; follow up tests not yet done Non med diabetic but excellent control

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your urea is higher than desired and total protein is on the low side. In a diabetic, the one common issue may be renal disease. Discuss urine testing with your doctor. ...Read more

29

29
I was diagnosed? Ulcerative colitis, recent results show, (total)protein 8.7, serum albumin, 3.9, serum globulin 4.8. Should I be worried?

I was diagnosed? Ulcerative colitis, recent results show, (total)protein 8.7, serum albumin, 3.9, serum globulin 4.8. Should I be worried?

Labs, no; U.C., yes: The lab results you mentioned are not worrisome. However, the diagnosis of ulcerative colitis (uc) is significant & will impact your health for the long-term. To address uc, maintain excellent rapport with your GI doctor & report flares, take the medications he gives you, follow his advice regarding tobacco, diet, & to avoid Aspirin & nsaid's, &get regular colonoscopies for dysplasia surveillance. ...Read more

30

30
I have been having stiffness. Positive ana, sed rate of 54, high total protein 8.4 and globulin 4.2. >8.0 Sjogrens syndrome A. What might I have?

I have been having stiffness. Positive ana, sed rate of 54, high total protein 8.4 and globulin 4.2. >8.0 Sjogrens syndrome A. What might I have?

See details: Impossible to say without more specific information but problems such as lupus or other connective tissue disorders are certainly consideration. See a rheumatologist if you have not done so already. ...Read more