Doctor insights on:
Elevated Kappa Light Chain
Hello, my Dr. Told me my Kappa light chain is elevated at 26. she told me not to worry and we'll check again in 3 months. What else should I ask /?
Sounds reasonable: You have a minimal degree of change, this may be within the normal range. But a recheck of this test is a good idea just to be sure. It is a rare condition that you do not need to worry about unless you have some symptoms in the future. Do tell us your age as some such conditions primarily occur in older adults ...Read more
Causes if a polyclonal gammopayhy with elevated kappa and lambda free light chains? Seems to be of the IGG type slightly elevated count.
It can be caused by numerous inflammatory, infectious, and malignant causes, for example; TB, Rheumatoid arthritis, cirrhosis of the liver, lymphoma, and MS. A more extensive list, click on Table 3 link inside article below.
http://www. Aafp. Org/afp/2005/0101/p105.html
http://www. Ncbi. Nlm. Nih. Gov/pmc/articles/PMC356447/
Mild elevation could simply be a mild cold with a rhinovirus. No worries. ...Read more
Kappa light chain in upep. Elevated k/l chains in serum but ratio normal. Wbc, rbc in urine with 2g/d protein. More/which workup/specialist needed?
Nephrologist: You need a nephrologist to follow up on those tests, but your doctor or the doctor who ordered those tests can direct you better, wish you wellness ...Read more
Indefinitely.: If monoclonal igm gammopathy is fully evaluated and not associated with any malignancy (lymphoma or myeloma) then the diagnosis is mgus (monoclonal gammopathy of undetermined significance). The chances of progression are low, ranging from 0.1% to 1.0%/year. The majority of patients never get cancer. ...Read more
MGUS: Many monoclonal gammopathies can be stable for many years. The only way to know is have the immunofixation and several other tests performed periodically. A referral to the hematologist is appropriate here. ...Read more
Free kappa light chain is high, FLC ratio is 2.205, no monoclonal gammopathy. IgA 389.43, lgM 125.95 and lgG 1771.02 H. Should we be worried? Thanks.
No: Abnormal FLC ratio is not diagnostic of any disease. More than 50% of the people with increased levels of gamma globulins have abnormal FLC ratio without a disorder of the plasma cells. ...Read more
IgM is macroglobulin: Macroglobulinemia is the term for monoclonal igm. However what you described is confusing/erroneous term, igm kappa is not light chain gammopathy. Igm kappa, by definition is macroglobulin. ...Read more
24-hour urine kappa light chain 2.18 mg/dl, lambda can't be quantified, < 0.4 mg/dl. What does it mean, how do I calculate ratio/ rule out LCDD? Thx
It can: Yes, it can. It will depend on how much is the quantity of the monoclonal proteine, how many plasma cells on the bone marrow and ultimately whether one has end organ damages/ whether some other organs are affected significantly by the monoclonal protein. That is why some blood work, imaging study and bone marrow biopsy need to be done. ...Read more
Kappa light chain (monoclonal) and recurring sterile wbc rbc in urine with declining ckd patient. Anemia reverses on tnf-a inhibitors. Suggestions?
Had abnormal k/ light chain ratio six months ago; now ratio is wnl, but kappa level remains elevated three blood panels later. Thoughts?
I'm not sure I could: Make much of a prognostic distinction between an abnormal kappa/light chain ratio and kappa elevation. Produced within plasma cells, heavy and light chains bind together to form immunoglobulins. Typically producing more light chains than required, the plasma cells enter the blood as free light chains. The activity of myeloma/plasma cell growth is linked to the amount of free light chains in blood. ...Read more
Light chains elevated. Kappa 300 mg/dL lambda 200. Creat 1.5 CRP 1, ana 160:1. No MM. What diseases can cause this, rule out secondary amyloidosis?
Chronic inflammation: Chronic inflammation from any cause can cause increase in serum immunoglobulins, polyclonal hypergammaglobulinemia and many of those patients have elevated serum free light chains. Some of these patients even have abnormal K/L ratio which you do not. The results you described are not diagnostic of any illness. ...Read more
Kappa/lambda FLC ratio high (2.75) w/ normal K (10.21mg/dl) & low L (3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow
K/L ratio is not a useful test. About one third of patients without monoclonal immunoglboulin have an abnormal ratio, usually with kappa excess. If you must, the next step would be a bone marrow examination. You may consult this article that I wrote: https://www. Ncbi. Nlm. Nih. Gov/pubmed/27473738
At your age you are unlikely to have myeloma. ...Read more
Http://myeloma. Org/pdfs/U-Freelite-Eng2011_g2web. Pdf:
Go to the website above for good summary of KAPPA and LAMBDA values, and significance;;
Normal levels of serum free light chains are*:
• Kappa: 3.3–19.4 mg/L*
• Lambda: 5.71–26.3 mg/L*
• Kappa/lambda ratio: 0.26–1.65**
*Note: The units here are mg/L; different
laboratories use different units. It is important to
double-check the units used when comparing
numbers in lab values.
**Further Note: In patients with renal impairment,
it is recommended to interpret the results
of the Kappa/Lambda ratio with a modified
reference range of 0.37–3.1. ...Read more
I have both elevated kappa and Lambda with normal ratio does this mean I have MM. I am scheduled to see a hem/onc, neuro, and rhemy?
Multiple myeloma: Is not an easy disease to have or to diagnose. The findings you mentioned aren't peculiar to the disease, lot of other parameters are needed to diagnose, the most important in this context is the heamatologist/oncologist, together with the other specialists you have appointments with. Can't commit to a diagnosis on this limited platform, wish you wellness ...Read more
I had a IgA Heavy Light Chains (HLC), S test done. Ig K/L HLC Ratio, IgA Kappa, S and IgA Lambda, S were in normal range. What does this test mean?
All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, The tests you mentioned have a high number of false positives and false negatives and are or questionable value.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex. ...Read more
Can you get all amyloidosis if you have kappa rather than lambda light chains? I also have a kappa lambda ratio of 175
Yes: Listen, Jane. I'm worried about you. You're already on cyclophosphamide and dexamethasone -- extremely potent medications -- yet you list no illness for which they are indicated. It's not for your thyroid cancer. You have a duty to find out exactly what is happening with you, including getting a 2nd opinion from a physician who's explain clearly. Amyloid is confusing; be proactive. ...Read more
Test results came back and say Free Kappa Lt Chains, S 34.81 Free Lambda Lt Chains, s is 29.22Kappa, lambda ratio is 1.19. Is it myeloma What is test 4
Light chains: Light chains (kappa and lambda) are a part of the immunoglobulin molecues the body makes. A given plasma cell only makes one type of light chain, most commonly this is kappa. When immunoglobulin cells proliferate like a neoplasm, then one type will overwhelm the others. Your values are nearly even, and the ratio is not abnormal, so it is unlikely that you have myeloma or another Ig-producing lesion. ...Read more
In lymphocyte phenotyping of periferial blood, what is the normal percentage for Kappa and Lambda light chains?
0.26-1.65 K/L ratio: Free light chains will normally be present in the blood at low levels, with a kappa/lambda ratio of about 0.26 to 1.65. Increased kappa free light chains and a higher kappa/lambda ratio may mean a plasma cell disorder producing excess monoclonal kappa chains. Increased lambda free light chains and a lower kappa/lambda ratio may mean a plasma cell disorder producing excess monoclonal lambda chains. ...Read more
I have 549igA, 37 sedimentation rate westergren, 21.64 free kappa lt chains, s, and kappa/lambda ratio, s is 1.66 What does this mean?
All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, Why were these tests done? Do you have any symptoms? Kappa/lambda ratio is generally a useless test. IgA of 549, per se is not a problem. Sed rate is in the normal range.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex. ...Read more
My haematologist says my kappa lambda ratio is seriously skewed. Kappa light chains @580 paraproteins 30. Does this imply a poor outcome?
Bad ratio: I am surprised you do not ask your oncologist questions about your outcome. Did you not ask? If you did, did you not get a response that you understood. You oncologist (o) knows your case best of all. Give your o a call and get your answer from the physician who knows you best of all. ...Read more
My IgG is mod low. My dr said I wasn't making antibodies either. Now it shows gamma in my urine and elevated kappa/lamba ratio of 18.25.Whats the cause?
Pls c a hematologist: If u haven't seen a hematologist already, u better arrange to c someone soon, ur doctor would help u in that aspect, if he/she is a hematologist, ask 4 more clarification and a side consult of a clinical immunologist would help too, good luck. ...Read more
What is the significance of having low serum levels of kappa and lambda free light chains? I had high ch50 and normal C3 and c4.
The: Concern would be low ch50 and low C3 ; c4, like in lupus. Elevations in kappa or lambda would be of concern for myeloma, not to worry about these levels. ...Read more
Kappa Lambda ratio u 1.92 (L) Free kappa LT chains ur 32.10 (H) Free Lambda LT chains ur 16.70 (H) 24 hour urine What does this mean?
I've just found out that 3 tests show low kappa/lambda ratio, with lambda light chain levels increased. Do these results mean a thing without m protein?
Check with your doc: Kappa and lambda are parts of immunoglobulins which are proteins certain white blood cells make to fight infections. These are referred to as polyclonal since they come from different cells. Some blood disorders can produce lots of m (monoclonal) kappas or lambdas that come from a single, usually malignant cell. Ask your doctor who ordered the lab test to help interpret your specific results. ...Read more
What is the significance of IGA Kappa Monoclonal in Beta? 36 y.o. with slightly elevated wbc (14-21k) for past year.
MGUS: This type of protein disorder is difficult to characterize at first, but the good news is that it's not showing the definitive signs of multiple myeloma or one of the other related serious disorders. This needs to be monitored closely, though, by a rheumatologist or immunologist. Best of luck to you. ...Read more
In 2 yrs been 8 times for bloodwork twice it showed faint IgM kappa protein and all other tests showed no IgM kappa and had light chain test negative?
Gamma spike: It may be nothing, it needs to be monitored, no major worries. ...Read more
What does elevated Igg-2364 and gamma globulin 2.2 mean with polyclonal gammopathy and Kappa and lambda typing increased?
Nothing serious: Polyclonal gammopathy does not have the seriousness of monoclonal gammpathy. Firstly your IgG and total globulin levels are only mildly elevated, so It may not mean any disease. One cause is chronic inflammation (infections) such as Chronic arthritis or chronic liver disease, conditions which can be checked out or ruled out easily if you ask your doctor and seek his/her advice about it. ...Read more
Question about lab results from hematologist. Free kappa light chains serum 19.97 (range is 3.30-19.40mg/l) Normal lambda and ratio.
What for?: What are you being tested for? All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, Serum free light chain assay and kappa/lambda ratio are unreliable tests. Better would be have serum and urine protein electrophoresis. ...Read more