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Doctor insights on: Elevated Ig G Antibody In Lupus

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Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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I have CBC test where monocytes are high, liver enzymes ALT high; also EBV IgG positive, CMV IgG positive CMV IgM normal.. Hiv negative at 32 weeks.

I have CBC test where monocytes are high, liver enzymes ALT high; also EBV IgG positive, CMV IgG positive CMV IgM normal.. Hiv negative at 32 weeks.

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, it would help to have the actual values of the results. The one item of interest is high ALT. If you drink alcohol, stop entirely for three months and redo the test. Other results are okay. ...Read more

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My serum test is negative for endomysial antibody iga, ttg tissue transglutasminase iga, gliadin antibody igg. But positive for gliadin antibody iga?

My serum test is negative for endomysial antibody  iga, ttg tissue transglutasminase iga, gliadin antibody igg. But positive for gliadin  antibody iga?

Treat the person: Lab tests mean nothing in isolation, and have many false positives and false negatives. The decision to make a trial of a gluten-free diet will be between you and your gastroenterologist or dermatologist based on the big picture. ...Read more

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Does highly elevated antinuclear antibody result always mean systemic lupus erythematosus?

Does highly elevated antinuclear antibody result always mean systemic lupus erythematosus?

Not always: Unfortunately, there is no single laboratory test that absolutely rules in or out systemic lupus erythematosis (sle). Although a highly positive antinuclear antigen (ANA) is common in sle, diagnosis is based on a careful history, physical exam and laboratory evaluation. ...Read more

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What causes high IgG antibodies but negative igm?

What causes high IgG antibodies but negative igm?

Immunity: Igm is the first line of defense and reacts first, then long term immunity is provided by igg. So a positive igg and negative igm to something means an old exposure. ...Read more

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Do elevated gliadin antibodies IgG and IgA mean gluten sensitivity?

Do elevated gliadin antibodies IgG and IgA mean gluten sensitivity?

TTG: I woul recommend having a ttg IgA antibody and possible duodenal bx , in doing so a diagnosis of celiac disease can be made. If if asymptomatic, there may be benefit from a gluten free diet especially if small bowel inflammation noted. ...Read more

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Ebv panel. Ebv nuc antigen igg=157, early ag igg=12.7, EBV VCA igg=112, EBV VCA igm=10.6. Please explain. Concerned about spleen. Symp=fatigue/fog?

Ebv panel. Ebv nuc antigen  igg=157, early ag igg=12.7, EBV VCA igg=112, EBV VCA igm=10.6.  Please explain.  Concerned about spleen. Symp=fatigue/fog?

? Active infection: It's impossible for me to answer with certainty since i don't know the normal ranges your lab uses. If early ag & vca igm are elevated above normal this indicates active ebv infection.I don't know if it is acute or chronic without knowing your history. If chronic i see that as a sign of poor immune function.Immune-boosting herbs/supplements & IV vit c drips may help, but find why immunity is poor. ...Read more

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Cardiolipin antibodies IgM and urine protein 72mg/l ? Ana negative.

Cardiolipin antibodies IgM and urine protein 72mg/l ? Ana negative.

See details: The urine protein is within normal limits. How strongly positive is the igm cardiolipin. Only high levels of positivity have any clinical significance. Why were the tests ordered in the first place? ...Read more

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What does a high EBV viral nuclear capsid antibody, a high EBV viral capsid antibody IgG and a high IgM EBV viral capsid antibody mean, what's it mean?

Likely immunity,,: You've got antibodies to the ebv which likely means you were infected at some time in your life and you recovered and now your body has circulating antibodies to it. An igg antibody in particular indicates long term resistance. This virus usually causes asymptomatic infection so you probably fought it off and weren't aware of it. Best of luck. ...Read more

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Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6) what are implications?

Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen  ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6)  what are implications?

Nothing.: Ebv antibodies indicate you had a previous infection, but not active. The c-reactive protein needs a units indicator - that is either normal or somewhat elevated. The anti ss dna is extremely nonspecific and very rarely indicated; I have no idea why that was ordered, discuss with your doctor. ...Read more

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Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?

Blood tests showed high  antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere.  Is this likely lupus or a different automimmune?

Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read more

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What causes elevated histone antibody levels in bloodworm?

???: I am not sure about a correlation with blood worm and this antibody? Anti-histone antibodies are autoantibodies that are found in 50%-70% of patients with systemic lupus erythematosus (sle), but I am unawre of a correlation with blood worms? Posibly a pathologist may know of a correlation. ...Read more

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Reactivated EBV 9 months after first infection. Could i be immunodeficient? Antibody count: 65 ab VCA igm; 53 ea ab igg; 431 ab VCA igg; 289 ebna igg.

Reactivated EBV 9 months after first infection. Could i be immunodeficient? Antibody count: 65 ab VCA igm; 53 ea ab igg; 431 ab VCA igg; 289 ebna igg.

No: Unfortunately ebv stays alive forever in one's lymphocytes and can get activated easily in susceptible people without known immunodeficiency. However you may call that an immunodeficiency given that all people have been infected with it yet only few would have recurrent ebv problem. ...Read more

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Recurring fever with 2g proteinuria with 1.1-2.2 serum creat. ebv b19 cmv igg positive/elevated. Neph says igg means no current infection. Workup?

Still ask your doc: Since you have come this far in evaluation and care, it would be most logical and beneficial for you to bring all of your concerns and questions to your doctors since they would know your individual conditions more than anyone online. More online sporadic inquiry at this time may induce more unnecessary anxiety and fear. ...Read more

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ANA 1:80 speckled, SM, RNP, SCL-70 detected.Leukocyte, urate, alkaline phosphate,creatinine low. Albumin, triglycerides high. Pos HAV, HBV. Rhem. Neg?

ANA 1:80 speckled, SM, RNP, SCL-70 detected.Leukocyte, urate, alkaline phosphate,creatinine low. Albumin, triglycerides high. Pos HAV, HBV. Rhem. Neg?

Not enough info: Lab tests need to be evaluated in the context of the clinical symptoms. You need this issue evaluated by a rheumatologist ...Read more

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I'm having negative DNA ,Sm and Rnp antibodies, but positive sm/rnp antibody,and high ANA titre speckled,so what is the diagnosis ?

I'm having negative DNA ,Sm and Rnp antibodies, but positive sm/rnp antibody,and high ANA titre speckled,so what is the diagnosis ?

Lupus: These serologies are rather non specific. The speckled ANA is non specific. In Systemic Lupus Erythematosis (SLE) it is usually homogeneous in its staining. Anti-Sm and Anti RNP can be see in mixed connective-tissue diseases and overlaps with SLE, scleroderma and myositis. As often is the case a specific diagnosis cannot be made. You need to see a Rheumatologist. ...Read more