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Doctor insights on: Elevated Ca 125 Ovarian Cyst

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Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal ...Read more

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Cyst (Definition)

A cyst is a structure or mass that consists of a cellular lined sac. It is typically filled with fluid but may be filled with solid material. It can be congenital, traumatic, or acquired. They may develop nearly anywhere in the body and usually require complete excision for eradication or they are likely to recur. Fluid filled sacs that are not cellular lined ...Read more


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What does it mean when you have mildly elevated ca 125? I have a 15cm ovarian cyst. Does that mean its cancerous?

Nothing out of..: ...Context. Ca.125 is used to follow up response to treatment in patients with cancer of the ovary but a slightly elevated level can come from non malignant causes (and it can be normal even if there is cancer). It is not considered a screening test. Whoever ordered it probably had very valid reasons to do so and I'm sure he/she can explain its implications to you in the proper context. Best 2u. ...Read more

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7 CM ovarian cyst, ca-125 levels elevated (48), roma score & all blood tests good. Previously had nasopharyngeal cancer. Recurrence or endometrioma?

Likely endometrioma: At your age, ovarian cancer would be exceedingly rare. Ca-125 levels can be elevated in young women for a variety of reasons that have nothing to do with cancer. Nasopharyngeal cancer and ovarian have no relation to each other. Your doctor should tell you what features or characteristics the ovarian cyst has, this will tell you what kind of cyst it is. Good luck! ...Read more

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Can an ovarian cyst raise a ca-125 test?

Yes: Many benign conditions can cause a mild to moderate elevation in ca-125. Talk it over with your doctor. ...Read more

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I have an ovarian cyst and my ca-125 is 30; what should I do now?

I have an ovarian cyst and my ca-125 is 30; what should I do now?

Ask MD ordering test: If there is a history of ovarian cysts and/or abnormal test, a woman definitely needs to be seek input from a specialist or subspecialist in gynecology. That is important to receive their interpretation and recommendations for now and the future. At some point she might need to be evaluated further. Rarely cancer can occur and can be suggested by imaging, so it might be ordered in some cases. ...Read more

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My ca125 normal but I may have abnormal he 4. What does this mean. I am seeing gynoncologist. Have a left ovarian cyst being monitored help?

Neither test: Is fda approved for diagnosing ovarian cancer and the he4 has to be interpreted together with a radiographic study. Since I do not have that information, and it sounds like you have a cyst, I would relax and follow the advice of your gynocologist. ...Read more

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I have a complex ovarian cyst should I request ca 125 test?

I have a complex ovarian cyst should I request ca 125 test?

Maybe: Talk it over with your doctor. Things to consider are 1) your age and menopausal status, 2) previous history of endometriosis, 3) size of the mass, 4) ultrasound appearance, 5) duration of the problem., 6) family history of ovarian cancer. Remember that ca-125 may be elevated in many benign conditions, as well as ovarian cancer. ...Read more

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Mildly complex ovarian cyst 4.5cm in postmenausal woman. Ca125 is 15. Having surgery tomorrow so worried! Can it be something bad? Help!

Mildly complex ovarian cyst 4.5cm in postmenausal woman. Ca125 is 15. Having surgery tomorrow so worried! Can it be something bad? Help!

Talk to doctor: Many women will develop cysts in their life. The vast majority are benign, but some do develop into cancer. Having a ca 125 that low is a good sign, but no one can tell until the cyst is examined by a pathologist after surgery. After surgery, your doctor will be able to give you more detailed answers. ...Read more

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I am 47. Have a 5cm simple ovarian cyst on left. CA 125 ok. Taking primolut tablets. Now have slight pain on both left/right sides. Is cyst growing?

I am 47. Have a 5cm simple ovarian cyst on left. CA 125 ok. Taking primolut tablets. Now have slight pain on both left/right sides. Is cyst growing?

Follow up visit: We would not be able to know the status of the cyst without an examination and sonogram. Consider scheduling follow up with your doctor to determine what is causing the pain. ...Read more

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Have 5cm ovarian cyst that is partially solid. CA125 is negative. What are chances it is cancerous? Dr says looks suspicious but reassured CA125 neg

Ca 125 no value: Most markers in the serum are Ca or carbohydrate antigens which have no diagnostic value. The can be absent from cancer or dx inflammation such as cirrhosis. A pure cystic lesion of ovary can be watch for possible changes. When there is trabeculation or any solid component the only diagnosis is when the ovary is removed, probably laparoscopally, the path dx made and treatment if necessary. ...Read more

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Had a ca-125 Value is 190H Reference range <35 (U/mL) Please help. I have Ovarian cysts and I am very nervous! ?

Elevated CA-125: CA-125 elevation is seen in many scenarios, which may include but are not limited to cancer, infection, inflammation, and even benign conditions like menstruation. Follow up with your doctor for further testing and physical exam to narrow down the diagnosis. Good luck ...Read more

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In addition to a 5cm ovarian cyst that is painful, my ca 125 was 383 and I am 50 yrs old. Does this indicates cancer present?

In addition to a 5cm ovarian cyst that is painful, my ca 125 was 383 and I am 50 yrs old. Does this indicates cancer present?

Possibly: I would certainly suggest a transvaginal ultrasound and check the normal range (0-35) however, this depends on your specific lab technique and value range. Please see your GYN ASAP. ...Read more

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2 ovarian cyst, one 8 CM and the other 6cm. Had vus done, low level echos. Going back in 2 months for review. Ca-125 in normal limits. Concered?

2 ovarian cyst, one 8 CM and the other 6cm. Had vus done, low level echos. Going back in 2 months for review. Ca-125 in normal limits. Concered?

Low degree of concer: Most common cause of such benign cysts are functional cysts that are very common in reproductive age females. Unless, presenting with symptoms (pain, nausea, vomiting, fever etc), your physician may opt to follow them with a repeat us in 3-6 months. Unless you have strong family hx of cancer, or personal hx of cancer, there is a low level of suspicion for ovarian cancer. ...Read more

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Ca125 high had ovarian cysts now hot sweats extreme fatigue what's the next step?

Next Step: It is unclear what would have lead to testing a Ca-125 in a 26 year old female. Now that it has been demosntrated to be elevated in the setting of ovarian cycsts further evaluation should take place. The likley next step would be pelvic imaging with an US to urther characterize the cysts. It should be noted that ca-125 is not specific and can elevated for many reasons, not just ovarian cancer. ...Read more

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I have 13x10x11 CM simple fluid filled ovarian cyst, normal ca-125 result I don't want to remove my ovary how can I save it? Is laparoscopy better?

I have 13x10x11 CM simple fluid filled ovarian cyst, normal ca-125 result I don't want to remove my ovary how can I save it? Is laparoscopy better?

Could be: I have removed many cysts like this laparoscopically while saving the ovary, but the size you give (13 cm?) is concerning. It is safe to remove this and conserve the ovary if the concern for malignancy is low; you need to discuss this with your doctor/surgeon and good luck. ...Read more

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I had a CA-125 done for ovarian cysts (10.5cm and 4cm) Test came back 190. Had another test weeks later and new u/s. Cyst is now 8.4 and CA-125 is 110. Is this even possible? Cysts are hypoechoic cystic lesions possibly endometriomas & endometriosis.

CA-125 testing: CA- 125 testing is notoriously inaccurate when it comes to testing for ovarian cancer especially when endometriosis is a part of the equation. IF there is continued concern most MD's will take a "look/see" with the laparoscope and confirm a definitive diagnosis. ...Read more

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Dr. James Chapman
125 Doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more


Dr. Eric Weisman
2 Doctors shared insights

Ovarian Cyst (Definition)

A growth (often balloon like) on an ovary. It is often thin walled ...Read more