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Doctor insights on: Elevated C3 Serum Levels In Lupus Panel

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What causes elevated histone antibody levels in bloodworm?

What causes elevated histone antibody levels in bloodworm?

???: I am not sure about a correlation with blood worm and this antibody? Anti-histone antibodies are autoantibodies that are found in 50%-70% of patients with systemic lupus erythematosus (sle), but I am unawre of a correlation with blood worms? Posibly a pathologist may know of a correlation. ...Read more

Serum (Definition)

Serum is the component of blood that does not contain cells or clotting factors. It does contain electrolytes an ...Read more


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Inorgan.Phosphate0.77, serum total protein63, serum globulin14, all slightly low. Norm. Calcium &albumin.Tsh9.25, known hypothyroidism. Further tests?

Inorgan.Phosphate0.77, serum total protein63, serum globulin14, all slightly low. Norm. Calcium &albumin.Tsh9.25, known hypothyroidism. Further tests?

TSH is WAY high!: Must get on a higher dose of synthroid (thyroxine). This can be life threatening, get treated asap, ! other thyroid tests need to be done to know what needs to be done, and to come to a diagnosis. ...Read more

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For what reason serum cu and ceruloplasmin levels are paradoxically low in wilson's disease?

For what reason serum cu and ceruloplasmin levels are paradoxically low in wilson's disease?

Not paradoxical: The problem is that copper can't get out of certain cells. The reason for ceruloplasmin being low is under study; since it carries copper, this metal also tends to be low. Checking serum copper and serum ceruloplasmin as a screen for wilson's misses up to a quarter of cases, especially if the person is already sick with anything. ...Read more

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In blood work, does elevated gamma globulin (m-spike) often cause the total serum globulin to be elevated as well?

In blood work, does elevated gamma globulin (m-spike) often cause the total serum globulin to be elevated as well?

Tt could: Since, total globulin level usually includes all kinds of globulins (alpha, m spike etc). An immunoelectrophoresis can further characterize the m spike. ...Read more

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High cortisol levels on 2 blood tests? Why?

High cortisol levels on 2 blood tests? Why?

How high?: It's important to know how high the tests were above the normal range (were they clinically significant?). Cortisol is produced by the adrenal glands which is under control by the pituitary. The problem could be either one. Your doctor who ordered the cortisol should be able to tell you the next step of workup. If the tests were indeed very high, you will need more testings before treatment. ...Read more

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Can high blood protein levels or Sjogren's syndrome cause elevated liver enzymes test results?

Can high blood protein levels or Sjogren's syndrome cause elevated liver enzymes test results?

Sjogren possible: But not likely with high serum protein. There is a condition called primary biliary cirrhosis that is associated with Sjogren and certain drugs used for Sjogren can potentially affect liver as well. Best thing to do is to see/talk to a rheumatologist. ...Read more

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Why are cu and ceruloplasmin levels paradoxically low in wilson's disease?

Why are cu and ceruloplasmin levels paradoxically low in wilson's disease?

Minor mystery: Copper is low because ceruloplasmin is low; most copper in the blood is carried on the protein. Nobody really knows why ceruloplasmin tends to be low in Wilson's, and I hope that you also know that in about 30% of Wilson's patients it is not low at all, making is a very poor screening test. ...Read more

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Lab results as follows: ANA w/titre and pattern 1:320 and thyroid peroxidase ab 484.0....Are the two related? Would hashimoto's cause high ANA level?

Lab results as follows: ANA w/titre and pattern 1:320  and thyroid peroxidase ab 484.0....Are the two related? Would hashimoto's cause high ANA level?

No: You have an elevated thyroid peroxidase (tpo) antibody because you have a tendency towards autoimmunity. The elevated tpo causes hoshimoto's. The tendency towards autoimmunity causes the high ANA level. ...Read more

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What do high ALT levels in blood test indicate?

Liver or muscle: Alt is a liver enzyme that is also present in muscle tissue. High levels could mean some inflammation of either of those areas but you need other, more specific tests to analyze the alt level correctly. ...Read more

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Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

False positive rate: There is 30% or so false positive rate of kappa/lambda ratio in people without MGUS, myeloma or other disorders. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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What causes high IgE levels in blood?

What causes high IgE levels in blood?

Allergy, Parasites: Unless you have an immunoglobulinopathy, it is usually caused by hypersensitivity to a substance (allergy) or parasitic infection (e.g. Worms). ...Read more

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Have borderline low C3 and C4 complement levels and low 1:80 titre positive ANA speckled. With symptoms relating to sle and sjorgrens - atypical ?

Have borderline low C3 and C4 complement levels and low 1:80  titre positive ANA speckled. With symptoms relating to sle and sjorgrens - atypical ?

Atypical for what?: Rheumatic disease generally requires a cluster of suggestive symptoms which is supported by lab studies. I do not know your symptoms, but your labs are not particularly suggestive of anything. ...Read more

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What condition(s) causes someone to have high total serum protein, high albumin, normal globulin and high total calcium levels?

What condition(s) causes someone to have high total serum protein, high albumin, normal globulin and high total calcium levels?

Dehydration.: There are no diseases that specifically increase albumin. Therefore in order to get an elevated concentration there must be a decrease in the amount of water in the system. This would also account for the normal globulin. Calcium is bound to Albumin so that elevated Albumin will elevate your calcium levels as well. ...Read more

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Elevated levels of antinuclear antibodies and bilirubin go with what disease?

Elevated levels of antinuclear antibodies and bilirubin go with what disease?

Autoimmune disease: Elevated ANA associated with autoimmune diseases. Elevated bilirubin associated with gall bladder and pancrease (pancrelipase). Not aware of how the two can be related. ...Read more

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Would high cortisol cause a high CRP or would elevated CRP cause high cortisol in blood tests?

Would high cortisol cause a high CRP or would elevated CRP cause high cortisol in blood tests?

No to both: Spot cortisol levels are of limited usefulness. Nobody really knows what to make of C-reactive protein except in a few special cases anyway. ...Read more