Doctor insights on:
Elevated Beta 2 Microglobulin
All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, You may consult this site for information on this topic.
http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/9234 ...Read more
This may help: http://labtestsonline.org/understanding/analytes/beta-microglob/tab/test/.Get a more detailed answer ›
I had blood test & the results are as follows INR 1.12
APTT ratio 1.16
Beta-2 Microglobulin 1.50mg/L. Can you tell me if they are normal?
Do healthy individuals have some (within normal range as per laboratory) beta 2 microglobulin in their blood?Or is any value, even if w/in range, bad? Normal range per lab is <2.52 and my value was 1.74.
Beta 2 microglobulin is 1.5 ,is it normal?have not been diagnosed with any myeloid malignancy(not been tested) but Immature grans is 0.6, normal CBC
I must caution you: ...that, without knowing the units associated with these values, I can't be certain that yours are normal. That said, a granulocyte count of less than 2% and beta 2 microglobulin of less than 16 mcg/dl are both normal values. However, as always, history, physical exam & other lab tests must be taken into consideration when interpreting test results. Best wishes. Dr. Anne ...Read more
Can there be different opinion on beta 2
microglobulin and bone marrow biopsy regarding detection on multiple myeloma?
Beta 2 Microglobulin: Is a way of following myeloma response to therapy. The problem is that it can be elevated in other conditions- including benign ones. I've seen it very high in patients with kidney dysfunction. So the leel could be different than the bone marrow, which is the only real way to prove multiple myeloma. ...Read moreSee 1 more doctor answer
What other tests to rule our lymphoma or safe to say likely not the issue? EBV reactivated w/pregnancy (+EA, neg IgM), strange neuro issues, all blood work normal (CBC, LDH, Beta 2 Microglobulin) imaging normal (ultrasound neck/abdo/pelv, brain MRI).
Lymphoma: Lymphoma is a pathological diagnosis which can only be diagnosed by biopsy (lymph node biopsy or bone marrow biopsy) followed by pathological analysis by trained pathologist. All the blood work you listed and imaging can not and will not be able to make the lymphoma diagnosis. EBV infection may increase certain lymphoma incidence, but its alone should not be used for diagnosis. ...Read moreSee 1 more doctor answer
Lab data: Without clinical correlation it may mean nothing. Beta 2 microglobulin in patients on hemodialysis can aggregate into amyloid fibers in joint spaces, (dialysis-related amyloidosis). It is also elevated in patients with multiple myeloma or lymphoma but is not diagnostic of these disease. It may account for secondary amyloidosis. As an isolated finding there is no telling what it means. ...Read more
B2 microglobulin: ..can be elevated in many diseases, but is usually used to estimate prognosis & monitor progress in patients with multiple myeloma. A level less than 4 MICROGRAMS (not milligrams) is associated with a good prognosis. However, without having any clinical information about you, I can't say much more than that. ...Read more
After 6 cycles of rchop 21 and 30gy of igrt for stage 1 grade 3 nhl, beta2-microglobulin is 2600 ng/ml. Is this high level a cause of concern?
Axilary & supraclavicular lymph nodes swollen both underarm, neck node not swollen beta2-microglobulin 2.21h, poss sarc dx, no infection, cancer issue?
Might need biopsy: You have significant lymphadenopathy which could be the result of an infection or could be related to a malignancy. Most primary care docs will treat with antibiotics and then refer for a biopsy if no improvement within a couple weeks. If a biopsy is needed it can often be done by an interventional radiologist (needle biopsy) and then sent to a pathologist for evaluation. ...Read more
Beta-2 microglobulin: is a protein found on the surface of many human cells, including white blood cells. Increased production or destruction of these cells causes B2M levels in the blood to increase. If it is elevated, and how much it is elevated, generally correlates with tumor cell load. Early, mild cases may not result in elevation of B2M; more advanced cases typically would--can't reliably estimate a percentage. ...Read more
I have fevers, high wbc's with high neutrophils, positive anca, and elevated beta 2 microglobin along with proteinuria. How urgent is this?
Serious: You should see your primary care doctor to discuss your above problem and ask for referral to see a rheumatologist. Infection should be ruled out as you are also diabetic. Condition called wagener's granulomatosis or other autoimmune condition should be evaluated. ...Read more
Do you rule out aps if anticardiolipin antibody and beta 2 glycoprotein (both IgG and igm) are often elevated but in borderline and weakly positive range?
See below: There are certain criteria that must be met in order for one to have aps. One of which is that one must have some type of thrombotic event. Antibodies alone do not make the diagnosis. Without knowing full details regarding your case, it is difficult to say whether you do or not. ...Read moreSee 2 more doctor answers