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Doctor insights on: Elevated Beta 2 Microglobulin

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What does a high beta-2 microglobulin indicate?

What does a high beta-2 microglobulin indicate?

Disease activity: Beta 2 microglobulin is not diagnostic of a given disease but is usually an indicator of disease severity, e.g., multiple myeloma, lymphoma and some inflammatory conditions. See this site for more info.

http://emedicine.medscape.com/article/2086864-overview#aw2aab6b2 ...Read more

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What are normal beta 2 microglobulin levels in a healthy individual?

What are normal beta 2 microglobulin levels in a healthy individual?

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, You may consult this site for information on this topic.
http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/9234 ...Read more

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What does a test result for beta 2 microglobulin of 2.47 mean?

What does a test result for beta 2 microglobulin of 2.47 mean?

B2M: It means that b2m is high. The normal range is <0.2. It is not a diagnostic test. It is done to follow the disease and prognosis for mm, leukemia, cancer, and kidney function. It is done with other diagnostic modalities. Good luck. ...Read more

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My recent blood test INR 1.12 APTT ratio 1.16 Beta-2 Microglobulin 1.50mg/L are they ok?

My recent blood test
INR 1.12
APTT ratio 1.16
Beta-2 Microglobulin 1.50mg/L
are they ok?

It depends: Yes these values are all within normal limits, but depending upon the issues of what these tests were performed for that could either be a good thing or a bad thing or possibly indifferent. ...Read more

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Beta 2 microglobulin is 1.5 ,is it normal?have not been diagnosed with any myeloid malignancy(not been tested) but Immature grans is 0.6, normal CBC

Beta 2 microglobulin is 1.5 ,is it  normal?have not been diagnosed with any myeloid malignancy(not been tested) but Immature grans is 0.6, normal CBC

I must caution you: ...that, without knowing the units associated with these values, I can't be certain that yours are normal. That said, a granulocyte count of less than 2% and beta 2 microglobulin of less than 16 mcg/dl are both normal values. However, as always, history, physical exam & other lab tests must be taken into consideration when interpreting test results. Best wishes. Dr. Anne ...Read more

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Can there be different opinion on beta 2 microglobulin and bone marrow biopsy regarding detection on multiple myeloma?

Can there be different opinion on beta 2 
microglobulin and bone marrow biopsy regarding detection on multiple myeloma?

Beta 2 Microglobulin: Is a way of following myeloma response to therapy. The problem is that it can be elevated in other conditions- including benign ones. I've seen it very high in patients with kidney dysfunction. So the leel could be different than the bone marrow, which is the only real way to prove multiple myeloma. ...Read more

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Dr. Le Wang Dr. Wang
3 doctors agreed:
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What other tests to rule our lymphoma or safe to say likely not the issue? EBV reactivated w/pregnancy (+EA, neg IgM), strange neuro issues, all blood work normal (CBC, LDH, Beta 2 Microglobulin) imaging normal (ultrasound neck/abdo/pelv, brain MRI).

Dr. Le Wang Dr. Wang
3 doctors agreed:
What other tests to rule our lymphoma or safe to say likely not the issue? EBV reactivated w/pregnancy (+EA, neg IgM), strange neuro issues, all blood work normal (CBC, LDH, Beta 2 Microglobulin) imaging normal (ultrasound neck/abdo/pelv, brain MRI).

Lymphoma: Lymphoma is a pathological diagnosis which can only be diagnosed by biopsy (lymph node biopsy or bone marrow biopsy) followed by pathological analysis by trained pathologist. All the blood work you listed and imaging can not and will not be able to make the lymphoma diagnosis. EBV infection may increase certain lymphoma incidence, but its alone should not be used for diagnosis. ...Read more

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My beta2 microglobulin is 2.47. What does that mean?

My beta2 microglobulin is 2.47.  What does that mean?

Lab data: Without clinical correlation it may mean nothing. Beta 2 microglobulin in patients on hemodialysis can aggregate into amyloid fibers in joint spaces, (dialysis-related amyloidosis). It is also elevated in patients with multiple myeloma or lymphoma but is not diagnostic of these disease. It may account for secondary amyloidosis. As an isolated finding there is no telling what it means. ...Read more

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Specimen of clotted blood Results-- B2 Microglobulin=3.10 mg/l (Normal - 0.81 to 2.19 mg/l)?

Specimen of clotted blood
Results-- B2 Microglobulin=3.10 mg/l (Normal - 0.81 to 2.19 mg/l)?

B2 microglobulin: ..can be elevated in many diseases, but is usually used to estimate prognosis & monitor progress in patients with multiple myeloma. A level less than 4 MICROGRAMS (not milligrams) is associated with a good prognosis. However, without having any clinical information about you, I can't say much more than that. ...Read more

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After 6 cycles of rchop 21 and 30gy of igrt for stage 1 grade 3 nhl, beta2-microglobulin is 2600 ng/ml. Is this high level a cause of concern?

After 6 cycles of rchop 21 and 30gy of igrt for stage 1 grade 3 nhl, beta2-microglobulin is 2600 ng/ml. Is this high level a cause of concern?

B2M is a nonspecific: Marker of cell turnover. The value would be hard to interpret if ordered during or shortly after cancer therapy. It has prognostic importance as a baseline (prior to treatment). ...Read more

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Axilary & supraclavicular lymph nodes swollen both underarm, neck node not swollen beta2-microglobulin 2.21h, poss sarc dx, no infection, cancer issue?

Might need biopsy: You have significant lymphadenopathy which could be the result of an infection or could be related to a malignancy. Most primary care docs will treat with antibiotics and then refer for a biopsy if no improvement within a couple weeks. If a biopsy is needed it can often be done by an interventional radiologist (needle biopsy) and then sent to a pathologist for evaluation. ...Read more

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Is beta-2-micro globulin typically elevated in lymphoma patients?

Is beta-2-micro globulin typically elevated in lymphoma patients?

A prognositic factor: levels are incorporated into staging system for multiple myeloma. Higher levels in 75% cases can correlated with higher tumor burden. ...Read more

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Elevated Beta-2-microalbumin. What could cause this?

Elevated Beta-2-microalbumin. What could cause this?

Abnormal Proteins: Usually elevation in this protein is related to abnormal regulation of its production by your immune system. Occasionally there can lab/technique error, but I would suspect a blood disorder typically. ...Read more

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How often is Beta-2-micro albumin elevated in lymphoma??

How often is Beta-2-micro albumin elevated in lymphoma??

Beta-2 microglobulin: is a protein found on the surface of many human cells, including white blood cells. Increased production or destruction of these cells causes B2M levels in the blood to increase. If it is elevated, and how much it is elevated, generally correlates with tumor cell load. Early, mild cases may not result in elevation of B2M; more advanced cases typically would--can't reliably estimate a percentage. ...Read more

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I have fevers, high wbc's with high neutrophils, positive anca, and elevated beta 2 microglobin along with proteinuria. How urgent is this?

I have fevers, high wbc's with high neutrophils, positive anca, and elevated beta 2 microglobin along with proteinuria.  How urgent is this?

Serious: You should see your primary care doctor to discuss your above problem and ask for referral to see a rheumatologist. Infection should be ruled out as you are also diabetic. Condition called wagener's granulomatosis or other autoimmune condition should be evaluated. ...Read more

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Do you rule out aps if anticardiolipin antibody and beta 2 glycoprotein (both IgG and igm) are often elevated but in borderline and weakly positive range?

Do you rule out aps if anticardiolipin antibody and beta 2 glycoprotein (both IgG and igm) are often elevated but in borderline and weakly positive range?

See below: There are certain criteria that must be met in order for one to have aps. One of which is that one must have some type of thrombotic event. Antibodies alone do not make the diagnosis. Without knowing full details regarding your case, it is difficult to say whether you do or not. ...Read more

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Beta hCG of 1.2 two weeks after sex?

Beta hCG of 1.2 two weeks after sex?

Means not pregnant: A BHCG less than 5 means that you are not pregnant. 2 weeks after sex the test is accurate ...Read more