Doctor insights on:
Elevated Anticardiolipin Antibody
Depends: Antiphospholipid syndrome (aps) is an autoimmune disorder characterized by thromboses, complications of pregnancy, and certain laboratory abnormalities. Anti-cardiolipin of the IgA isotype are not part of the laboratory criteria for aps due to lack of specificity. Consult with your doctor regarding which type of antibody was tested and significance in your clinical situation. ...Read more
It depends: Just having those antibodies may be harmless. However, they can be associated with certain diseases; cause thrombosis (occlusion) of blood vessels, reduce the number of platelets (the cells in the blood that are crucial for clotting) and bleeding in the skin. Most depends on how high the level of those antibodies is in your system. ...Read more
Do you rule out aps if anticardiolipin antibody and beta 2 glycoprotein (both IgG and igm) are often elevated but in borderline and weakly positive range?
See below: There are certain criteria that must be met in order for one to have aps. One of which is that one must have some type of thrombotic event. Antibodies alone do not make the diagnosis. Without knowing full details regarding your case, it is difficult to say whether you do or not. ...Read moreSee 2 more doctor answers
See below: Anti-cardiolipin antibodies (aca) are antibodies directed against cardiolipin and found in several diseases, including syphilis, antiphospholipid syndrome, and lupus. They are a form of anti-mitochondrial antibody. Aca can be classified as either igm, igg or IgA and they can be β2-glycoprotein dependent or independent. Anti-phospholipid antibodies can either be lupus anticoagulants or the aca. ...Read moreSee 1 more doctor answer
Connective Tissue Dx: With a positive ana, you must now characterize it. The positive anticardiolipin abs need to quatified for the 3 types: igg, igm, and iga. The ones that are likely to cause thrombotic issues are in order: igm, igg, and iga. You need a rheumatologic or immunologic evaluation. ...Read more
Anticardiolipin: There is a realtionship to higher amounts of miscarriages with this antibody. About 2% to 4% of the general population has antiphospholipid antibodies, and over half of those have primary anticardiolipin (an antiphospholipid) antibody syndrome. Antiphospholipid syndrome is a factor in about 15% of women who have recurrent miscarriages. ...Read more
High risk OB doctor: You want to be cared for by a high risk obstetrical specialist. These doctors have a lot of experience taking care of patients with this problem. You want to be a routine case, if possible, and that is more likely with a specialist. You visit them before getting pregnant. Usually Heparin and Immune Globulin treatments are used to help your body through the pregnancy in addition to good care. ...Read more
How could syphilis test be negative and anticardiolipin autoantibody be positive? Do some syphilis tests only look for antibodies to t. Pallidum?
Does anticardiolipin IgM (115ug/l) x 3 have any significance when it is rasied on its own? LA Positive but beta glycoprotein & other antibodies neg
Higher future risk: The cause of an elevated aCL without other diseases is unknown. That said, 50% of people with + lupus anticoagulant have or will have SLE. Presumably, manifestations require the aCL plus another problem - infection, one of a number of drugs, pregnancy, BC pills, etc. The significance is the higher than normal risk in the face of future immunological injury ...Read more
I have antiphospholipid syndrome (aps), with anticardiolipin antibodies igg/gpl extremely high. Others are normal. What problems arise with a high igl?
Antiphospholipid syn: Antiphospholipid syndrome (aps) is a disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss. Some patients with aps have no evidence of any definable associated disease, while, in other patients, aps occurs in association with sle or another rheumatic or autoimmune disorder. Traditionally, these have been referred to as primary or secondary aps, respectivel. ...Read moreSee 1 more doctor answer