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Doctor insights on: Elevated Anticardiolipin Antibody

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What are the cuases of elevated anticardiolipin antibodies?

What are the cuases of elevated anticardiolipin antibodies?

Auto-immunity: Anticardiolipin antibodies are commonly present in systemic lupus and related disorders. These antibodies are also present due to syphilis. See this site for more info.
http://www. Ncbi. Nlm. Nih. Gov/pmc/articles/pmc95774/. ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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Does anybody know about elevated anticardiolipin antibodies?

Auto-antbody: Anti-cardiolipin antibodies are seen in two main conditions, (1) auto-immune disease like systemic lupus, anti-phopholipid syndrome and (2) syphilis. ...Read more

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What happens if you have elevated anticardiolipin antibodies?

What happens if you have elevated anticardiolipin antibodies?

Depends: Antiphospholipid syndrome (aps) is an autoimmune disorder characterized by thromboses, complications of pregnancy, and certain laboratory abnormalities. Anti-cardiolipin of the IgA isotype are not part of the laboratory criteria for aps due to lack of specificity. Consult with your doctor regarding which type of antibody was tested and significance in your clinical situation. ...Read more

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Is it dangerous to have elevated anticardiolipin antibodies?

Is it dangerous to have elevated anticardiolipin antibodies?

It depends: Just having those antibodies may be harmless. However, they can be associated with certain diseases; cause thrombosis (occlusion) of blood vessels, reduce the number of platelets (the cells in the blood that are crucial for clotting) and bleeding in the skin. Most depends on how high the level of those antibodies is in your system. ...Read more

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Do you rule out aps if anticardiolipin antibody and beta 2 glycoprotein (both IgG and igm) are often elevated but in borderline and weakly positive range?

Do you rule out aps if anticardiolipin antibody and beta 2 glycoprotein (both IgG and igm) are often elevated but in borderline and weakly positive range?

See below: There are certain criteria that must be met in order for one to have aps. One of which is that one must have some type of thrombotic event. Antibodies alone do not make the diagnosis. Without knowing full details regarding your case, it is difficult to say whether you do or not. ...Read more

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What is the definition or description of: anticardiolipin antibodies?

See below: Anti-cardiolipin antibodies (aca) are antibodies directed against cardiolipin and found in several diseases, including syphilis, antiphospholipid syndrome, and lupus. They are a form of anti-mitochondrial antibody. Aca can be classified as either igm, igg or IgA and they can be β2-glycoprotein dependent or independent. Anti-phospholipid antibodies can either be lupus anticoagulants or the aca. ...Read more

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Antinuclear antibody and anticardiolipin ab both positive, what are implications?

Antinuclear antibody and anticardiolipin ab both positive, what are implications?

Connective Tissue Dx: With a positive ana, you must now characterize it. The positive anticardiolipin abs need to quatified for the 3 types: igg, igm, and iga. The ones that are likely to cause thrombotic issues are in order: igm, igg, and iga. You need a rheumatologic or immunologic evaluation. ...Read more

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Anticardiolipin antibodies--what are they and effects of pregnancy?

Anticardiolipin: There is a realtionship to higher amounts of miscarriages with this antibody. About 2% to 4% of the general population has antiphospholipid antibodies, and over half of those have primary anticardiolipin (an antiphospholipid) antibody syndrome. Antiphospholipid syndrome is a factor in about 15% of women who have recurrent miscarriages. ...Read more

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How do you have a successful pregnancy with anticardiolipin antibody?

How do you have a successful pregnancy with anticardiolipin antibody?

High risk OB doctor: You want to be cared for by a high risk obstetrical specialist. These doctors have a lot of experience taking care of patients with this problem. You want to be a routine case, if possible, and that is more likely with a specialist. You visit them before getting pregnant. Usually Heparin and Immune Globulin treatments are used to help your body through the pregnancy in addition to good care. ...Read more

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Do you have lupus if you have anticardiolipin antibodies? What else do you look for with this?

Do you have lupus if you have anticardiolipin antibodies? What else do you look for with this?

Not necessarily: Antiphospholipid antibodies can occur where there is no underlying disease or can be associated with lupus, rheumatoid arthritis and other disorders. ...Read more

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How could syphilis test be negative and anticardiolipin autoantibody be positive? Do some syphilis tests only look for antibodies to t. Pallidum?

How could syphilis test be negative and anticardiolipin autoantibody be positive? Do some syphilis tests only look for antibodies to t. Pallidum?

Different types of: Tests. There are two different types of tests, one being RPR and it has more false positives due to auto-antibodies. Tests specific for treponemal antigens are more specific. ...Read more

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Does anticardiolipin IgM (115ug/l) x 3 have any significance when it is rasied on its own? LA Positive but beta glycoprotein & other antibodies neg

Does anticardiolipin IgM (115ug/l) x 3 have any significance when it is rasied on its own? LA Positive but beta glycoprotein & other antibodies neg

Higher future risk: The cause of an elevated aCL without other diseases is unknown. That said, 50% of people with + lupus anticoagulant have or will have SLE. Presumably, manifestations require the aCL plus another problem - infection, one of a number of drugs, pregnancy, BC pills, etc. The significance is the higher than normal risk in the face of future immunological injury ...Read more

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I have antiphospholipid syndrome (aps), with anticardiolipin antibodies igg/gpl extremely high. Others are normal. What problems arise with a high igl?

Antiphospholipid syn: Antiphospholipid syndrome (aps) is a disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss. Some patients with aps have no evidence of any definable associated disease, while, in other patients, aps occurs in association with sle or another rheumatic or autoimmune disorder. Traditionally, these have been referred to as primary or secondary aps, respectivel. ...Read more

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What does antinuclear antibody detected on cardiolipin ab (igg) results imply?

What does antinuclear antibody detected on cardiolipin ab (igg) results imply?

Different tests: ANA can be found with connective tissue diseases and also in normal people. Cardiolipin antibodies suggest circulating anticoagulant, which can be found in people with lupus, but also with many other diseases. ...Read more

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My results showed that I have antinuclear antibody on cardiolipin ab (igg). What are the implications?

Several conditions: Cross reactivity of antibodies against cardiolipin and dna, either double strands or single strand, is typically found in autoimmune diseases, such as systemic lupus erythematosus. However, these antibodies, sometimes, are also found in syphilis. ...Read more

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I have an anticardiolipin antibody and am 4 weeks pregnant when will I need to begin taking heparin in order for my pregnancy to have the best chance?

I have an anticardiolipin antibody and am 4 weeks pregnant when will I need to begin taking heparin in order for my pregnancy to have the best chance?

Consult your OB now: Please consult your OB immediately. You should be under regular antenatal care and should have seen your OB by now, if not sooner. Decision to put you on Heparin requires more evaluation than is feasible in this forum. ...Read more

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Seizures, low white and red b.C., anticardiolipin antibodies, numbness in legs and arthritis. What does this add up to? What should the doc be lookingfor

See details: The anticardiolipin antibodies could be the cause of the seizures secondary to clot formation either in a blood vessel of the brain or a clot thrown from the heart. Also, an underlying lupus often is associated with seizures. ...Read more

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Hepatocellular disease, seizures, low blood count, anticardiolipin antibodies, arthritis, rash on hands and numbness in legs. What does this all mean?

Hepatocellular disease, seizures, low blood count, anticardiolipin antibodies, arthritis, rash on hands and numbness in legs. What does this all mean?

Auto-immune disorder: You have described features of auto-immune disorder. For example, a person with lupus could have all these features. You need evaluation and treatment by a physician in consultation with specialists in more than one field. ...Read more

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Probability for lupus w/ seizures, peeling rash on hands, arthritis, low WBC and rbc, kidney/liver symt, and anticardiolipin antibodies and fam. Hist?

High: The answer lies with the results of the blood tests. If the ANA is positive you have lupus. If the ANA and other autoantibodies are negative then you can still have lupus. Trust your rheumatologist. ...Read more

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Seizures mouth ulcers hepatocellular disease low blood count anticardiolipin antibodies 1:80 speckled ANA osteoarthritis spine Si joints LUPUS maybe?

Seizures mouth ulcers hepatocellular disease low blood count anticardiolipin antibodies 1:80 speckled ANA osteoarthritis spine Si joints LUPUS maybe?

Lupus, maybe: I think you may well be right. You should be under the care of a competent rheumatologist. A Coombs test would be in order to see if you have hemolytic anemia. ...Read more

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My anticardiolipins IgM has come back high in the last two years ranging from 113 to 53 recently what does this mean? My ANA & Other antibodies Neg.

My anticardiolipins IgM has come back high in the last two years ranging from 113 to 53 recently what does this mean? My ANA & Other antibodies Neg.

Anticardiolipins: Usually that only causes a problem for the fetus. Are you thinking of getting pregnant in the near future? If not, then I would just forget about it for the moment. ...Read more

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If I test negative for anti cardiolipin antibodies once, does that mean I 100% don't have them or can it become positive?

No: There is no way to predict when a disease condition or lab result may change although there are risk factors which may increase your chance of getting a disease. The human body is not static and in fact is being modified by epigenetics and environmental exposure constantly even as we speak ...Read more

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I miscarried twice. Doc advised me to do thrombophilia screen, anticardiopin antibody and lupus anticoagulant - what are they?

I miscarried twice. Doc advised me to do thrombophilia screen, anticardiopin antibody and lupus anticoagulant - what are they?

Tests for clotting: These are tests for abnormal clotting factors that, if present, may be causing you to miscarry. Someone of these causes can be treated during pregnancy. ...Read more

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Anticardiolipin IgM elevated, what does it mean?

Antiphospholipids: Autoimmune antibodies can be formed against natural (normal) cell surface proteins. When this happens, adverse effects can occur. Anti-cardiolipin antibodies have been associated with abnormal blood clotting events and recurrent spontaneous miscarrages. See a hematology specialist for advice on this problem. ...Read more

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