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Doctor insights on: Elevated Ana

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Would Ehlers-Danlos syndrome cause an elevated ANA? Titre 1:640.

Would Ehlers-Danlos syndrome cause an elevated ANA? Titre 1:640.

NOT: Generally..... this syndrome is inherited whereas a elevated ANA indicates an ACQUIRED rheumatic disorder and a complete rheumatological evaluation is indicated!

Hope this is helpful
Dr Z ...Read more

Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


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What do you recommend if I have elevated ANA and anti dsdna antibody?

What do you recommend if I have elevated ANA and anti dsdna antibody?

See details: I would recommend you consult with a rheumatologist to determine if these values have any clinical significance. ...Read more

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I was told I have elevated ANA and that I have lupus. I then was diagnosed with celiac. Does celiac cause elevated ANA?

I was told I have elevated ANA and that I have lupus. I then was diagnosed with celiac. Does celiac cause elevated ANA?

Autoantibodies: No.

There are 4 types of antibodies. The type responsible for Celiac disease is an IgA whereas the ANA is an IgG.

Of note, normal people can have elevated ANA. A diagnosis of lupus requires other confirmatory tests. ...Read more

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Highly elevated ANA (1:640, but neg for all AI diseases) 1 month ago; however, retested yesterday (antinuclear ab ELISA) now showing negative (0.4 U). New test false negative since not using IFA? If still highly +, would have ELISA likely shown +?

Highly elevated ANA (1:640, but neg for all AI diseases) 1 month ago; however, retested yesterday (antinuclear ab ELISA) now showing negative (0.4 U). New test false negative since not using IFA? If still highly +, would have ELISA likely shown +?

Agree need IFA: Agree the lab needs to use IFA. The Elisa is a poor screening ANA. Why the Elisa was used is not clear. In fact a good lab wouldn’t screen with Elisa. The other ANA subsets are better for disease evaluation You rheumatologist is aware of this. Part of the answer depends on your full evaluation We see + ANA in a lot of other conditions perhaps including mono at times but this is not usual ...Read more

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Could cancer be suspect even with normal CBC and metabolic and uriine? Sed rate slightly elevated ANA + w/ spec pattern 1:640.

Could cancer be suspect even with normal CBC and metabolic and uriine? Sed rate slightly elevated ANA + w/ spec pattern 1:640.

Unlikely: Angie,

the labs you are reporting would fit more a rheumatological condition than cancer. The elevated sed rate indicates an inflammatory condition which the positive ANA would point more down the path of a rheumatological issue. Cancer is unlikely with these labs. ...Read more

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I think I may have ra. All tests neg with an elevated ana. Joints hurt and super stiff in the a.M. And lately rib cage hurts. I just feel awful. Ideas?

I think I may have ra. All tests neg with an elevated ana. Joints hurt and super stiff in the a.M. And lately rib cage hurts. I just feel awful. Ideas?

Blood Isn't Perfect: About 20% of RA patients never show it in their blood, and ANA is a screening test that only indicates more testing is needed. A rheumatologist can sort this out. ...Read more

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Cannot take statins due to muscle pain & slightly elevated ana. Current md wants me on Zetia or livalo (pitavastatin). I'm afraid of muscle pain again. Can I say no?

Yes, of course.: You are fully in charge of your body. Sometimes we as physicians are very focused on pharmaceutical options, but if it is not a life threatening issue then you are fully authorized to pursue more tolerable options such as dietary changes, supplements, herbals, etc. ...Read more

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Cause of unilateral edema from possible rotator cuff tear.; edema to neck, arm to hand and LLE 2+pitting. CRP always elevated, + ANA normalforedema?

Cause of unilateral edema from possible rotator cuff tear.; edema to neck, arm to hand and LLE 2+pitting. CRP always elevated, + ANA normalforedema?

Clot considered: Even though blood clots in the arm are not very common, swelling of the arm, especially from the upper arm to the hand raises the suspicion for a blood clot. Lymphedema is possible as well. Rotator cuff problems typically do not cause widespread swelling. The edema is not often visible to the naked eye and remains around the tendon. It's time to see a doc very soon, preferably in the next 24 hours ...Read more

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What could cause open sores on leh, elevated liver enzymes, chri ic fever, blood infections that great pseudo, ongoing fatigue, elevated ana?

Can't dx: This can't be diagnosed with the information that is available. A history, physical examination & other studies may be needed to determine cause/causes.
Once accurately assessed a treatment plan can be developed. ...Read more

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Enlarged hilar lymph node, bilateral ant groundglass opacities, rt pulm nodules, elevated ana, fam hist. Odds of lung cancer/metasticzd fromelsewhere?

Enlarged hilar lymph node, bilateral ant groundglass opacities, rt pulm nodules, elevated ana, fam hist. Odds of lung cancer/metasticzd fromelsewhere?

Let's not jump into: The worst conclusions. Your are 30 y/o, nonsmoker. If you look at the study, 1994, univ of miami, people who developed lung cancer under age 36 were mainly exposed to marijuana, inconclusive but something to think about. In all likelihood this is part of your rheum problem such as rheumatoid nodules or infectious such as fungal. You need a bronch/biopsy for dx. I wish you luck, keep spirits up. ...Read more

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Crp was high now normal. Sed rate elevated. Ana+w/speck pattern. Thyroid ok. Metabilic and CBC and urine ok. Little low vitamin d... Any idea?

Crp was high now normal. Sed rate elevated. Ana+w/speck pattern. Thyroid ok. Metabilic and CBC and urine ok. Little low vitamin d... Any idea?

Labs mean little: CRP and sed rate vary greatly for no obvious reason frmo day to day. A majority of americans run a low vitamin d due to our diets & habits. My one concern is if the ANA is at a high-titer, which warns of lupus or a variety of other possibilities, but labs mean nothing apart from the history and physical exam. ...Read more

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16yo w severe back pain radiating to rt side. Ct showed mesenteric adenitis. Mri showed schmorl node endplate changes at 4 levels elevated ana?

16yo w severe back pain radiating to rt side. Ct showed mesenteric adenitis. Mri showed schmorl node endplate changes at 4 levels elevated ana?

Schmorl Nodes: Are normal findings. You have some active inflammation (the adenitis) causing your pain (but it's probably not from your spine). This can be from a number of causes, your doctor knows you best, and can narrow down the possibilities. ...Read more

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I was just told I have an elevated positive ana level (1/80) should I be concerned about cancer?

No: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that an ANA of 1/80 in of itself is not worrisome. Do you have any symptoms? Were other tests done, if yes, what were the results. ANA is not a marker for cancer.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex. ...Read more

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After 50 mg prednisone for 5 days ESR (25) CRP (3.5) Are both slightly elevated? Ps. (ANA) has been positive for years

Stop worrying: As a pathologist, I'd consider that sed rate normal. CRP is really useful only as a sensitive screen so as not to miss folks with advanced atherosclerosis not yet symptomatic. I doubt it means anything here; just care for your vascular health. About 1 adult in 4 has a low-positive ANA. I'd ask for a full explanation from your physician as to why you were put on prednisone in the first place. ...Read more

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If a lupus panel was negative and awaiting serum electrophise test what would that tell? My sed rate is elevated and ANA positive w/ speckled pattern

Nothing specific: These findings are not specific. This will depend on your total evaluation and why these tests being done. The test alone do not make a diagnosis. ...Read more

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Anti ro ssa was low but present. Anti TG antiTpo antibodies elevated but ana w/ panel was (-) euthyroid. Has s/s responds to plaquenil (hydroxychloroquine) Differential Dx?

Anti ro ssa was low but present. Anti TG antiTpo antibodies elevated but ana w/ panel was (-) euthyroid. Has s/s responds to plaquenil (hydroxychloroquine) Differential Dx?

Sjögren's syndrome: Anti-ssa antibodies are most commonly associated with Sjögren's syndrome, but it does not confirm a diagnosis. Pts should may have symptoms of dry eyes and dry mouth, which are classic for Sjögren's syndrome. These ab's are also associated with connective tissue diseases such as lupus or SLE. However, a pt must have clinical and lab abnormalities to meet the diagnosis. ...Read more

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Have chronic elevated WBC's, ANA titer and blood compliments, 1st rheumy said SLE, 2nd disagrees, I need answers. Have had ALL kinds of labs done.

Have chronic elevated WBC's, ANA titer and blood compliments, 1st rheumy said SLE, 2nd disagrees, I need answers. Have had ALL kinds of labs done.

How do you FEEL?: I agree with Dr. Vu. You may be perfectly healthy and this is simply you. The real question is not, "Do you have lupus? " but "Do we need to put you on some kind of medication to make you feel. Function better? " High WBC and especially high complement levels aren't usually a sign of lupus. Best wishes. ...Read more

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Lost 60 lbs over summer from diet and exercise. Up back pain since may. Hair loss sed rate elevated and ana+w/spec pattern. Lupus panel neg. Cbc ok?

Lost 60 lbs over summer from diet and exercise. Up back pain since may. Hair loss sed rate elevated and ana+w/spec pattern. Lupus panel neg. Cbc ok?

Inflammation: You describe a body that is generally inflamed. Diets that promote animal proteins (meat, chicken, fish, eggs, and dairy) are inflammatory. This may have been your situation. Read dr. Neal barnard's book foods that fight pain. He describes a plant-based, anti-inflammatory diet that will improve healing and decrease inflammation. Many of my patients have benefitted and no longer need medications. ...Read more

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Hair loss middle back pain. Like a burning feeling. Right flank gnawing pain. Doesn't hurt when sleeping. Elevated sed. Ana + spec pattern? Cbc ok.

Complex: Your description does not give clear picture. Discuss with your physician or seek 2 nd opinion. There are many causes of back pain from cardiac and shingles to arthritis and herniated disk. Talk to your doctor. ...Read more

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Esr is elevated but my ANA and CRP are normal! Does this mean that I don't have an autoimmune disease?

Esr is elevated but my ANA and CRP are normal! Does this mean that I don't have an autoimmune disease?

Autoimmune disorders: Esr is an inflammatory marker tha is elevated in inflammatory disorders, anemia, pregnancy, , kidney cancers, tb, lymphoma to name a few. It measures rate at which red cells sediment in a test tube in 1 hour. It is used more to monitor response to treatmemt is such disorders and helps in diagnosis of certain conditions. Esr can be elevated with negative ANA in several autoimmune disorders. ...Read more

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What does an elevated CRP and ANA test and low vitamin d indicate?

What does an elevated CRP and ANA test and low vitamin d indicate?

3 separate things: ANA is a screening test. A positive result only indicates more testing might be needed to look for autoimmune diseases.

Crp means something somewhere in the body is inflamed for some reason (and yes it really is that vague).

Low vitamin d means you needs more vitamin d in the diet or in the form of vitamin pills. ...Read more

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Same kind of burning pain in my knees is now happening to my achillis tendon. What's going on? Any suggestions? No injury. Pos ANA elevated esr

Same kind of burning pain in my knees is now happening to my achillis tendon. What's going on? Any suggestions? No injury. Pos ANA elevated esr

Go back to doctor: This could be due to dozens of things, from an autoimmune condition, back problems and so on and so forth. You need to be fully evaluated and we cannot diagnose you on the internet. Good luck. ...Read more

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Know pain and stiffness pos ANA elevated ESR fatigue family history of RA but dr says it's osteoarthritis does this sound right? Go to rheumo anyways?

See Rheum: Given the elevated ESR and positive ANA I would recommend you see rheum. If you are a 28 yo female you are the "right" age where RA and/or lupus etc. Need to be ruled out. ...Read more

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Feeling I'll for 6 months, angioedemia, low grade fevers, sore throats, headaches, fatigue, poisitive ana, elevated c4, elevated c1q, what is it?

Need for evaluation: What you described suggests an auto-immune disease and needs to be investigated for a proper diagnosis and treatment. You may wish to consult a rheumatologist. For a start, try to quit smoking! ...Read more

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Knee pain and stiffness elevated ESR pos ANA fatigue normal X-ray family history of lupus and ra. Does X-ray rule those out? What could be wrong

Knee pain and stiffness elevated ESR pos ANA fatigue normal X-ray family history of lupus and ra. Does X-ray rule those out? What could be wrong

?: Knee xray only tells us how much gross damage or deformity is present
what you are probably dealing with is inflammation
you should discuss this with pcp and prbably get referral to rheumatologist
could be either lupus or RA or both or possibly something else. ...Read more

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Have had mri/ CT scan nothing suspicious. High CRP elevated sed rate. Ana + w/speckled pattern. Could this be cancer? Do have middle back pain.

Need further eval: You will need more evaluation. A complete autoimmune panel should be done at least. I don't know your symptoms, but from your limited information, you do have some inflammation process going on in your body and there is a possibility that this may be an autoimmune process. Discuss further with your doctor. ...Read more

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Would a chest xray show lung cancer? I had CT of chest nov 2012 and it was clear. I have +ana elevated sed and low grade fevers. Up back pain 1 year.

Would a chest xray show lung cancer? I had CT of chest nov 2012 and it was clear. I have +ana elevated sed and low grade fevers. Up back pain 1 year.

Chest X ray: A chest x ray would show lung cancer. Your lab results suggest youmight have an auto immune disease. See an internist or a rheumatologist for a definitive diagnosis. ...Read more