Doctor insights on:
Elevated Alpha 1 Antitrypsin
What does " ALPHA-1-ANTITRYPSIN " mean? Component Standard Range Your Value 90 - 200 mg 218 why is mine elevated?
Alpha-1: Alpha-1-antitrypsin is a protein produced by the liver which helps to protect the liver and lungs from damage. Approximately 1 in 2, 500 people have a deficiency (hereditary) which puts them at higher risk for early lung (COPD) and liver disease (cirrhosis, cancer). This deficiency can be detected by a blood test.See 1 more doctor answer
Husband's 23&me results variant + for hemochromatosis 1mut and alpha-1 antitrypsin mz. Elevated ast/alt past 5 yrs, no s/s. Any sugg 4 his pcp?
Carrier: It sounds like your husband is a carrier, but less likely actually to be affected by, both hemochromatosis (i also carry it, it's a plus for me as a blood donor) and antitrypsin deficiency (mz's are fairly common and are unlikely to have catastrophic liver disease from it.) with fat in his liver, why not undertake husband-and-wife fitness as a top family priority?
Diagnosis of AAT def: Alpha-1-antitrypsin is a protease inhibitor of the enzyme elastase. Deficiency can result in disease of the lung, liver, and skin. The serum level is quantified in the diagnosis of aat deficiency. If the aat serum level is greater than 80 mg/dl, it is unlikely that the patient has clinically significant aat deficiency.
No: It may be mild or severe. You're born with it, you are likely to become short of breath in middle age (hopefully you are a non-smoker), and the liver disease may come on at any time in your life, or never.
AAT deficiency: Measurement of alpha-1-antitrypsin serum concentration is used to determine if a patient has the inherited disorder aat deficiency. If the aat serum level is greater than 80 mg/dl, it is unlikely that the patient has clinically significant aat deficiency.See 1 more doctor answer
Genetic disease: It's quite variable in severity. The lack of the helpful antitrypsin protein in the blood prevents the neutralization of enzymes from white cells that tend to decrease the elasticity of the lungs. The enzyme itself accumulates in the liver which can't get it into the circulation and this can ruin the liver. This can happen at any age and no one knows why it varies so much; or the liver may be fine.
Early emphysema: Early onset emphysema, especially in a non-smoker, is most common characterisitic of Alpha 1 at deficiency, other abnormalities include early onset liver disease.
Any: Shortness of breath usually develops from the lung disease in the 40's. The liver disease can show up at any age from infancy to later middle age, or never. Nobody knows why.
Genetic, familial: Genetic abnormality that can run in families, associated with emphysema, even without the usual triggers like tobacco use, and cirrhosis of the liver, even in the absence of triggers like chronic infection, alcohol use. Can cause problems in children and/or in adults. Can be tested for, can be rx'd.
Emphysema: Aat deficiency affects primarily the lungs, leading to copd, particularly a panacinar emphysema. Symptoms are variable, but usually involve shortness of breath on exertion, cough, or wheezing. It can also affect the liver, causing chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Necrotizing panniculitis is a rare clinical manifestation involving the skin.
Shortness of breath: Alpha 1 antitrypsin (aat) is a molecule in the blood and alveolar space. This naturally occuring molecule is protecting alveolar walls from breaking by trypsin which is also naturally occuring molecule during lipid metabolism of the cells. Trypsin is causing oxidative damage to the cells and needs to be scavenged. Aat deficiency is a genetic disorder with abnormal production of the aat molecule.
WebMD: See webmd for a thorough discussion.Get a more detailed answer ›
Liver tests: It seems this above normal in some of labs. It is low level that causes liver disease.
I had a stoolanalysis done and found out that I have a high pH value (8.0) and an increased level of Alpha-1-Antitrypsin (34, 2 U/ml). Whatdoesthismean?
Probably not much: Stool pH varies chaotically with diet and what bugs happen to be there. Stool antitrypsin is sometimes used to screen for protein-losing enteropathy. The units you give are not standard but I'll assume that they're elevated. If they are greatly above reference range, it's one more piece of information for the workup, suggesting at least some of the gut lining is significantly damaged.
Genetic problem: Because of this gene mutation, body becomes deficient in Alpha -1 - antitrypsin protein and manifests as chronic lung disease, just like in COPD pts but affects a younger population and affects the bases of the lung more than the apices. Fortunately it is available to take on a daily basis to bring the levels of a1at within 'normal' range.
Lack of alpha-1 AT: Trypsin is a protein (an enzyme) that the body uses to remove damaged/"unwanted" proteins. This protein needs to attack the right targets specifically but not nearby healthy necessary proteins. To help keep trypsin under control, another group of proteins have developed. Alpha-1 antitrypsin (alpha-1 AT) is a very important one. If a person is deficient, they tend to get emphysema at an early age.
- Talk to a doctor online
- Alpha 1 antitrypsin phenotyping
- Alpha 1 antitrypsin phenotype
- Alpha 1 antitrypsin carrier
- Stool alpha 1 antitrypsin
- Alpha 1 antitrypsin mz
- Alpha 1 antitrypsin mutation
- Alpha 1 antitrypsin quantitation
- Recombinant alpha 1 antitrypsin
- Alpha 1 antitrypsin protein