Top
20
Doctor insights on: Egfr Signaling Pathway

Share
1

1
Are ?Congenital heart disease related to a faulty signal transduction pathway?

Are ?Congenital heart disease related to a faulty signal transduction pathway?

Not likely.: Most congenital cardiac defects are due to multifactorial inheritance and environmental factors such as Folic Acid deficiency. I am not aware of specific studies linking them to a faulty signal transduction pathway, although such mechanisms frequently become the final common pathway of multiple etiological pathogenic factors.

2

2
How can congenital heart disease be related to a faulty signal transduction pathway?

How can congenital heart disease be related to a faulty signal transduction pathway?

Too complex: There are many types of congenital disease with many different and often unknown causes. So. There is no pat answer to this broad question.

See 1 more doctor answer
4

4
How does a cell signaling pathway work and how can it be translated into movement?

How does a cell signaling pathway work and how can it be translated into movement?

Controls pathways: Cell signaling pathways/molecules help regulate gene transcription/translation and cell kinetics downstream. They may also affect recpetor configuration, reaction speed, etc. Are regulators of metabolic and other pathways. Can also be important in pathologic pathways such as in cancer development/growth.

5

5
Can you explain the cell signaling pathway involved in cystic fibrosis, what goes wrong, and the right way for it to work?

Can you explain the cell signaling pathway involved in cystic fibrosis, what goes wrong, and the right way for it to work?

CFTR: The cftr protein is on the surface of cells lining the lungs, intestine, pancreas, other organs. When activated by camp, a signaling molecule, it opens to release chloride from the inside of the cell. Water follows the chloride out of the cell. In cystic fibrosis, cftr is non-functional, so the mucus at the surface of the epithelial cell gets dehydrated and thick.

6

6
Could any expert explain the cell signaling pathway involved in cystic fibrosis, what goes wrong, and the right way for it to work? Thanks!

Could any expert explain the cell signaling pathway involved in cystic fibrosis, what goes wrong, and the right way for it to work? Thanks!

Start with this link: http://www.sciencedaily.com/releases/2010/02/100214143133.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fcystic_fibrosis+%28ScienceDaily%3A+Health+%26+Medicine+News+--+Cystic+Fibrosis%29

Get a more detailed answer ›
7

7
How does imatinib stop the signaling pathway of mutated kit in patients with gist?

How does imatinib stop the signaling pathway of mutated kit in patients with gist?

Inhibits enzyme: The drug fits precisely into a "pocket" in the enzyme encoded by the mutant gene, blocking the enzyme's function.

8

8
What is the pathway that alcohol takes through the body? What organs are affected?

What is the pathway that alcohol takes through the body? What organs are affected?

Alcohol: Alcohol affects stomach , liver and brain , and blood cells. Can cause cirrhosis. It depends on how often and how long it is used. Can affect pancreas. Bone marrow.

9

9
What does this mean? "there is a shortened p-r interval consistent with an intra-nodal accessory pathway"

What does this mean? "there is a shortened p-r interval consistent with an intra-nodal accessory pathway"

Nodal conduction: "intra-nodal pathway"? You may have accelerated av nodal conduction from what is thought as inter-nodal pathways - three potential ones- from sinus node to the av node which is likely normal for age. If there is evidence of a delta wave than you may have wpw. Nodofasicular or nodoventricular pathways can give shortened pr intervals. Any palpitations?Have an electrophysiologist review your ecg.

See 2 more doctor answers
10

10
How can the allergy pathway work?

How can the allergy pathway work?

Allergies: Allergy is when your immune system mistakes a harmless substance for a dangerous one and triggers the release of chemicals from mast cells into your body, thus creating symptoms like runny nose, sneezing, watery eyes, and itching. When people who have allergies encounter an allergen, their immune system produces antibodies, called IgE antibodies, that are specific to that substance.

11

11
What is the pathway of spinal fluid?

What is the pathway of spinal fluid?

See below: In short from choroid plexus to arachnaoid granulations. For more info consult this: http://www.sciencedirect.com/science/article/pii/S1879729611001013

12

12
What does complement alternative pathway test show?

What does complement alternative pathway test show?

Mechanism for diseas: If you have a disease compatible with a complemented activated disorder, this test may be performed. It is an attempt to detect a mechanism for your disease condition.

13

13
What to do if I can't understand the pathway..so anyone can give any of metabolism bilirubin explanation?

What to do if I can't understand the pathway..so anyone can give any of metabolism bilirubin explanation?

Get help: The porphyria synthesis and breakdown pathways are elementary if you understand organic chemistry and its application to general metabolism, incomprehensible if you do not. Nobody here is going to be able to tell you anything more. Perhaps there has been a problem with sequencing the topics.

14

14
What is water's pathway to the kidneys?

What is water's pathway to the kidneys?

Blood: Kidneys filter blood, so impaired blood flow to the kidneys (either through blockage or drop in blood pressure) results in lowered filtration, lowered urine output, and kidney damage.

15

15
How do glucocorticoids activate the intrinsic pathway?

There are many: "intrinsic" pathways. Which one do you mean?

16

16
Can SVT be caused by electrolyte imbalances or is it always an accessory pathway?

Can SVT be caused by electrolyte imbalances or is it always an accessory pathway?

Svt: not always pathway, set can be triggered by significant electrolyte imbalance

See 1 more doctor answer
18

18
Doc said over phone that my alternative(alternate) complement pathway is activated. What things could cause this? What does it mean?

Immune process: Complement proteins in the blood coat bacteria, viruses, etc., to make them easier for the immune system to grab onto and destroy. They can be activated by your own antibodies (classical pathway) or may spontaneously activate themselves (alternative pathway). Activation can mean anything from you are fighting an infection to you have an autoimmune process. Talk with your doctor for more info.

19

19
I'm 36 and have 2 copies of APOE4 per Pathway Genomics. I have mild cognitive issues. What testing is appropriate that insurance will cover?

I'm 36 and have 2 copies of APOE4 per Pathway Genomics. I have mild cognitive issues. What testing is appropriate that insurance will cover?

Careful: Insurance ≠: issues. Typical larger issue is NMR-lipoproteins by Vantera Analyzer, the primary driver of arterial disease & strokes, along with ?ed BP. So optimize LDL to <400 nmol/L & large HDL to >9 umol/L by NMR along with HbA1c <5.0% & Systolic BP <120 mmHg. Also study the work of Leah Makley (more details later)

20

20
My baby is 7 months old having severe optic pathway dysfunction Dr are investigating for mucopolysacchroidosis. What should I do plz help me.

My baby is 7 months old having severe optic pathway dysfunction Dr are investigating for mucopolysacchroidosis. What should I do plz help me.

Breathe and catch : your breath until you know exactly what it is. Then work with the pediatrician to come up with a optimum treatment plan. Right now you must take care of you! If genetic, you can still affect postively the epigenetics (environmental, dietary impact) of the disease. Always get 2nd opinions too from an integrative medicine specialist!