Doctor insights on:
Egfr Signaling Pathway
Not likely.: Most congenital cardiac defects are due to multifactorial inheritance and environmental factors such as Folic Acid deficiency. I am not aware of specific studies linking them to a faulty signal transduction pathway, although such mechanisms frequently become the final common pathway of multiple etiological pathogenic factors. ...Read more
In 400 characters?!: Hi. See http://www.ncbi.nlm.nih.gov/pubmed/12099386Get a more detailed answer ›
Controls pathways: Cell signaling pathways/molecules help regulate gene transcription/translation and cell kinetics downstream. They may also affect recpetor configuration, reaction speed, etc. Are regulators of metabolic and other pathways. Can also be important in pathologic pathways such as in cancer development/growth. ...Read more
Can you explain the cell signaling pathway involved in cystic fibrosis, what goes wrong, and the right way for it to work?
CFTR: The cftr protein is on the surface of cells lining the lungs, intestine, pancreas, other organs. When activated by camp, a signaling molecule, it opens to release chloride from the inside of the cell. Water follows the chloride out of the cell. In cystic fibrosis, cftr is non-functional, so the mucus at the surface of the epithelial cell gets dehydrated and thick. ...Read more
Could any expert explain the cell signaling pathway involved in cystic fibrosis, what goes wrong, and the right way for it to work? Thanks!
Start with this link: http://www.sciencedaily.com/releases/2010/02/100214143133.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fcystic_fibrosis+%28ScienceDaily%3A+Health+%26+Medicine+News+--+Cystic+Fibrosis%29Get a more detailed answer ›
Inhibits enzyme: The drug fits precisely into a "pocket" in the enzyme encoded by the mutant gene, blocking the enzyme's function. ...Read more
What does this mean? "there is a shortened p-r interval consistent with an intra-nodal accessory pathway"
Nodal conduction: "intra-nodal pathway"? You may have accelerated av nodal conduction from what is thought as inter-nodal pathways - three potential ones- from sinus node to the av node which is likely normal for age. If there is evidence of a delta wave than you may have wpw. Nodofasicular or nodoventricular pathways can give shortened pr intervals. Any palpitations?Have an electrophysiologist review your ecg. ...Read moreSee 2 more doctor answers
Allergies: Allergy is when your immune system mistakes a harmless substance for a dangerous one and triggers the release of chemicals from mast cells into your body, thus creating symptoms like runny nose, sneezing, watery eyes, and itching. When people who have allergies encounter an allergen, their immune system produces antibodies, called IgE antibodies, that are specific to that substance. ...Read more
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