Doctor insights on:
Egfr Signaling Pathway
Not likely.: Most congenital cardiac defects are due to multifactorial inheritance and environmental factors such as Folic Acid deficiency. I am not aware of specific studies linking them to a faulty signal transduction pathway, although such mechanisms frequently become the final common pathway of multiple etiological pathogenic factors.
Too complex: There are many types of congenital disease with many different and often unknown causes. So. There is no pat answer to this broad question.See 1 more doctor answer
In 400 characters?!: Hi. See http://www.ncbi.nlm.nih.gov/pubmed/12099386Get a more detailed answer ›
Controls pathways: Cell signaling pathways/molecules help regulate gene transcription/translation and cell kinetics downstream. They may also affect recpetor configuration, reaction speed, etc. Are regulators of metabolic and other pathways. Can also be important in pathologic pathways such as in cancer development/growth.
Can you explain the cell signaling pathway involved in cystic fibrosis, what goes wrong, and the right way for it to work?
CFTR: The cftr protein is on the surface of cells lining the lungs, intestine, pancreas, other organs. When activated by camp, a signaling molecule, it opens to release chloride from the inside of the cell. Water follows the chloride out of the cell. In cystic fibrosis, cftr is non-functional, so the mucus at the surface of the epithelial cell gets dehydrated and thick.
Could any expert explain the cell signaling pathway involved in cystic fibrosis, what goes wrong, and the right way for it to work? Thanks!
Start with this link: http://www.sciencedaily.com/releases/2010/02/100214143133.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fcystic_fibrosis+%28ScienceDaily%3A+Health+%26+Medicine+News+--+Cystic+Fibrosis%29Get a more detailed answer ›
Inhibits enzyme: The drug fits precisely into a "pocket" in the enzyme encoded by the mutant gene, blocking the enzyme's function.
What does this mean? "there is a shortened p-r interval consistent with an intra-nodal accessory pathway"
Nodal conduction: "intra-nodal pathway"? You may have accelerated av nodal conduction from what is thought as inter-nodal pathways - three potential ones- from sinus node to the av node which is likely normal for age. If there is evidence of a delta wave than you may have wpw. Nodofasicular or nodoventricular pathways can give shortened pr intervals. Any palpitations?Have an electrophysiologist review your ecg.See 2 more doctor answers
Allergies: Allergy is when your immune system mistakes a harmless substance for a dangerous one and triggers the release of chemicals from mast cells into your body, thus creating symptoms like runny nose, sneezing, watery eyes, and itching. When people who have allergies encounter an allergen, their immune system produces antibodies, called IgE antibodies, that are specific to that substance.
Mechanism for diseas: If you have a disease compatible with a complemented activated disorder, this test may be performed. It is an attempt to detect a mechanism for your disease condition.
What to do if I can't understand the pathway..so anyone can give any of metabolism bilirubin explanation?
Get help: The porphyria synthesis and breakdown pathways are elementary if you understand organic chemistry and its application to general metabolism, incomprehensible if you do not. Nobody here is going to be able to tell you anything more. Perhaps there has been a problem with sequencing the topics.
There are many: "intrinsic" pathways. Which one do you mean?
Svt: not always pathway, set can be triggered by significant electrolyte imbalanceSee 1 more doctor answer
It could be possible that a health professional or anybody in the know how please help me figure out a blood flow pathway for this?
For what?: Resubmit the question. The question in its present form makes no sense.
Doc said over phone that my alternative(alternate) complement pathway is activated. What things could cause this? What does it mean?
Immune process: Complement proteins in the blood coat bacteria, viruses, etc., to make them easier for the immune system to grab onto and destroy. They can be activated by your own antibodies (classical pathway) or may spontaneously activate themselves (alternative pathway). Activation can mean anything from you are fighting an infection to you have an autoimmune process. Talk with your doctor for more info.
I'm 36 and have 2 copies of APOE4 per Pathway Genomics. I have mild cognitive issues. What testing is appropriate that insurance will cover?
Careful: Insurance ≠: issues. Typical larger issue is NMR-lipoproteins by Vantera Analyzer, the primary driver of arterial disease & strokes, along with ?ed BP. So optimize LDL to <400 nmol/L & large HDL to >9 umol/L by NMR along with HbA1c <5.0% & Systolic BP <120 mmHg. Also study the work of Leah Makley (more details later)
My baby is 7 months old having severe optic pathway dysfunction Dr are investigating for mucopolysacchroidosis. What should I do plz help me.
Breathe and catch : your breath until you know exactly what it is. Then work with the pediatrician to come up with a optimum treatment plan. Right now you must take care of you! If genetic, you can still affect postively the epigenetics (environmental, dietary impact) of the disease. Always get 2nd opinions too from an integrative medicine specialist!