Doctor insights on:
Efficacy Of Methotrexate Treatment In Lupus
How effective is imuran for lupus or sjogrens? Methotrexate worked great for me but can't tolerate GI side effects even with injection.
Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more
Might methotrexate help w/dysautonomia symptoms caused by autoimmune disorder like lupus when standard tx (floninef & salt)don't' work but prednisone does?
May not be best: Dysautonomia due to lupus could be due to neurological involvement such as autonomic neuropathy, or due to adrenal suppression as a consequence of prolonged steroid treatment. In the first case Methotrexate might not be a strong enough immunosuppressor; its role in lupus is mainly limited to treating arthritis. In the second case, the treatment would be supplemental steroids such as florinef. ...Read moreSee 2 more doctor answers
Possible, but....: If you take mtx, make sure it is prescribed subcutaneously, since avoids high-concentration-first pass through your liver. Other options are pulsing with dexamethasone, taking oral hysdroxycholoroquine, oral gold, cellcept, and benlysta. This an issue for rheumatology and gastroenterology practitioners. ...Read more
I have no organ involvement in my lupus but its just a matter of quality of life, am i putting myself at great risk by starting methotrexate?
Some risk: Methotrexate (mtx) is not a great risk but there is some risk and you absolutely must use contraception if you re sexually active. If you have failed Plaquenil and you still have serious quality of life issues such as fevers, fatigue, joint pains, etc., it may be good to consider mtx or benlysta. Pain and fatigue can change your social life, home life, sex life, and work life. ...Read moreSee 1 more doctor answer
Someone told me that methotrexate dose use for lupus is no big deal & pts on it are not considered immunocompromised. I'd appreciate your opinion.?
Get routine checks: Regardless of the dose, this drug can cause compromise- varying from paient to pateint.Testing is rather routine and can spot a problem before it becomes serious. ...Read more
I was recent diagnosed witj lupus which is attacking my liver and kidneys. Is methotrexate safe to take if my liver is already messed up?
Can the typical dose methotrexate used for lupus increase ones chance of developing cancer? I'm worried about it. How many years is it "safe" to be on?
If lupus went into remission & i no longer needed methotrexate, would it likely cause leukopenia or not?
Lupus can cause leukopenia: Lupus can cause leukopenia. Methotrexate can cause leukopenia. So the reason you might have it depends on the rest of the manifestations of your lupus. Other reasons besides Methotrexate lupus can also cause leukopenia. Thus your evaluation would try to clarify all of this. ...Read more
After about how many weeks do you stop noticing improvement with methotrexate 4 arthritis or lupus where max improvement is reached? ~12 weeks?
Lupus erythematosus is a name given to a collection of autoimmune diseases, in which the human immune system becomes hyperactive and attacks normal, healthy tissues.Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood ...Read more
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