Doctor insights on:
Effects Of Coming Off Methotrexate
Many and quite safe!: Mtx is used in many autoimmune diseases with great effect. The drug is given IV in high doses to treat cancer. In much lower doses, given subcutaneously like insulin, with fewer side-effects than the same oral dose, does not go to the liver. And you absorb 100%, not the 40-90% when taken by mouth. Great drug. Ist line in ra! ...Read more
Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more
Plenty : XX oral dos: Methotrexate is a surprisingly effective drug for many forms of arthritis and the consensus 1st choice for RA by the acr and eular (european). The oral dosage is more problematic because of variable absorption and first-pass effect through liver. It is completely absorbed with sucutaneous injection and doesn't bolus liver. Hair loss can be a problem. Everyone should take 2mg of folic acid. ...Read more
Several.: Fatigue after taking your weekly dose. Gi quiziness. Hair loss. Potential liver issues, especially taken orally. Your white count can be lowered, as well as hemoglobin. Everyone on mtx should take folic acid. Monitoring for side effects (benefits too) should take place every three months or sooner. ...Read more
See details: It really depends of the specific side effect. Dividing the dose or switching to the subcutaneous form can help with GI issues. Taking folic can reduce other risks. ...Read more
Nausea, hair loss,:
There are many described that can be lessened by also taken folic acid.
the things we look for are many including nausea - sometimes called ucks, hair loss, mouth sore, low blood counts, liver changes,
Rare one, include lung problems and a type of lymphoma. You need to discuss this with your physician and help monitor you and reduce these risks. ...Read more
Can going from 22.5mg of methotrexate injections to 25mg (in a 6year old) increase your chance of side effects? So if didn't have before can have now?
Yes, definitely: A weekly dose of 22.5mg of Methotrexate injections is already a pretty high dose for a 6yo child, so I would not go up further. I would reduce it to 12.5 or 15mg of Methotrexate weekly injections and add either Enbrel (etanercept) (less painful) or humira (equally effective and better for eye inflammation and ibd-related arthritis).Talk to your rheumatologist about it. Biologics are very safe with fewer side efx. ...Read more
Rheummds:for dose 6 of methotrexate, dose is increased. I take on tues but concern w/ side effects & work. Okay to take 4 days early (sat from now on)?
Take it late.: It would be safer to delay the dose to the following saturday, rather than to take it early. ...Read more
For dose 6 of methotrexate for ctd, my dose is increased. I take on tues but concern w/ side effects & work. Okay to take 4 days early (sat from now on)? My rhemd said okay 2switch to a day that works.
Works: Methotrexate has become the standard of first choice forra treatment but rarely results in remission, ie no one can tell if you have it including the doctor. The risk is extremely low, although you cannot use alcohol, and is not usually used if ther is preexisting liver disease. Most patients have to add several other disease modifying drugs to get better. ...Read more
Not many: When Methotrexate is used to treat ectopic pregnancy, usually only one dose needs to be given. Therefore, most women will do well without any side effects. If they do have side effects, it will be mild and temporary. They include nausea, abdominal pain, sores in the mouth, dizziness, etc. ...Read more
See details: You have asked this question before. Side effects include GI irritation, infection risk, hair loss, allergic cough and pneumonitis, reduced blood counts, liver inflammation and increased risk of lymphoma. Do not permit this to scare you off. The advantages at preventing joint destruction far outweigh the risks. ...Read more
In general when methotrexate is causing to many side effects when treating jra what is next step?
TNF agents: Tnf agents are very effective.Get a more detailed answer ›
I have stopped taking my Crohn's medication (methotrexate)i was suffering severe side effects. I'm still incredibly sick & wondering when it will stop?
Rheummd says it's ok 2 change weekly methotrexate to a day that works 4 me. I take on tues. Now on dose #6 & dose is increased. Concern w/ side effects at work. Ok to switch to the sat or sun before?
No: Always best to follow the directions of a doctor who has seen and evaluated your problem. If having a concern call them and ask for clarification. ...Read more
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