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Doctor insights on: Effects Of Coming Off Methotrexate

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Do you have information on methotrexate uses and effects?

Do you have information on methotrexate uses and effects?

Many and quite safe!: Mtx is used in many autoimmune diseases with great effect. The drug is given IV in high doses to treat cancer. In much lower doses, given subcutaneously like insulin, with fewer side-effects than the same oral dose, does not go to the liver. And you absorb 100%, not the 40-90% when taken by mouth. Great drug. Ist line in ra! ...Read more

Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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Any methotrexate side effects?

Any methotrexate side effects?

Plenty : XX oral dos: Methotrexate is a surprisingly effective drug for many forms of arthritis and the consensus 1st choice for RA by the acr and eular (european). The oral dosage is more problematic because of variable absorption and first-pass effect through liver. It is completely absorbed with sucutaneous injection and doesn't bolus liver. Hair loss can be a problem. Everyone should take 2mg of folic acid. ...Read more

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What are some of the side effects of methotrexate?

Several.: Fatigue after taking your weekly dose. Gi quiziness. Hair loss. Potential liver issues, especially taken orally. Your white count can be lowered, as well as hemoglobin. Everyone on mtx should take folic acid. Monitoring for side effects (benefits too) should take place every three months or sooner. ...Read more

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How can we reduce the side effects of methotrexate?

How can we reduce the side effects of methotrexate?

See details: It really depends of the specific side effect. Dividing the dose or switching to the subcutaneous form can help with GI issues. Taking folic can reduce other risks. ...Read more

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What are the most common side effects of methotrexate?

What are the most common side effects of methotrexate?

Nausea, hair loss,: There are many described that can be lessened by also taken folic acid.
the things we look for are many including nausea - sometimes called ucks, hair loss, mouth sore, low blood counts, liver changes,

Rare one, include lung problems and a type of lymphoma. You need to discuss this with your physician and help monitor you and reduce these risks. ...Read more

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Does anyone know the withdrawal effects of methotrexate?

Does anyone know the withdrawal effects of methotrexate?

No true withdrawal!: People are put on mtx for reasons. Many are rheumatic problems that cause pain with inflammation. Stopping the drug can allow inflammation to return causing pain and lethergy. ...Read more

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How safe is methotrexate taken orally for long term? Are side effects likely? What are they?

Reasonably safe: Methotrexate is a relatively safe drug, even over the long term. I have patients taking it over 20 years without problems. You need to have lab tests done routinely and should be on Folic Acid as well. ...Read more

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Can going from 22.5mg of methotrexate injections to 25mg (in a 6year old) increase your chance of side effects? So if didn't have before can have now?

Can going from 22.5mg of methotrexate injections to 25mg (in a 6year old) increase your chance of side effects? So if didn't have before can have now?

Yes, definitely: A weekly dose of 22.5mg of Methotrexate injections is already a pretty high dose for a 6yo child, so I would not go up further. I would reduce it to 12.5 or 15mg of Methotrexate weekly injections and add either Enbrel (etanercept) (less painful) or humira (equally effective and better for eye inflammation and ibd-related arthritis).Talk to your rheumatologist about it. Biologics are very safe with fewer side efx. ...Read more

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For dose 6 of methotrexate for ctd, my dose is increased. I take on tues but concern w/ side effects & work. Okay to take 4 days early (sat from now on)? My rhemd said okay 2switch to a day that works.

For dose 6 of methotrexate for ctd, my dose is increased. I take on tues but concern w/ side effects & work. Okay to take 4 days early (sat from now on)? My rhemd said okay 2switch to a day that works.

Yes: It's okay to switch to Saturday. Remember not to do your blood tests on the same day as you take your methotrexate (MTX). The blood test monitoring for MTX is sometimes abnormal (but not significant) on the day or the day after taking MTX. ...Read more

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What are effects of taking methotrexate for rheumatoid arthritis?

What are effects of taking methotrexate for rheumatoid arthritis?

Works: Methotrexate has become the standard of first choice forra treatment but rarely results in remission, ie no one can tell if you have it including the doctor. The risk is extremely low, although you cannot use alcohol, and is not usually used if ther is preexisting liver disease. Most patients have to add several other disease modifying drugs to get better. ...Read more

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What are the comon side effects for methotrexate when used for ectopic?

What are the comon side effects for methotrexate when used for ectopic?

Not many: When Methotrexate is used to treat ectopic pregnancy, usually only one dose needs to be given. Therefore, most women will do well without any side effects. If they do have side effects, it will be mild and temporary. They include nausea, abdominal pain, sores in the mouth, dizziness, etc. ...Read more

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What are the side effects of methotrexate for psoriasis worth taking the risk?

Worth the risk: For more severe psoriasis, Methotrexate is definitely worth the risk and really has fairly low risk. Side effects include GI irritation, hair loss, reduced blood counts and liver inflammation. All of these are uncommon. ...Read more

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What are the long term effects for using methotrexate? What are the side effects

See details: You have asked this question before. Side effects include GI irritation, infection risk, hair loss, allergic cough and pneumonitis, reduced blood counts, liver inflammation and increased risk of lymphoma. Do not permit this to scare you off. The advantages at preventing joint destruction far outweigh the risks. ...Read more

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I am on methotrexate for severe psoriasis. Can I come off it as I have read of serious side effects. Thanks?

Yes, but: The risk of methotrexate toxicity is fairly low and your psoriasis will flare if you discontinue it. Before doing anything you should discuss this with your dermatologist. ...Read more

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My age is 29yrs. For psoriasis, I'm taking methotrexate 7.5 mg since 7yrs. Using this, what are the side effects to me in long term. Plz suggest?

Probably not much: This is a small dose of methotrexate. Assuming you have blood tests to screen for medication toxicity and these tests are normal, the long term risk is small. Make sure blood is screened for liver toxicity and reduced blood counts every 3 months. ...Read more

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I have stopped taking my Crohn's medication (methotrexate)i was suffering severe side effects. I'm still incredibly sick & wondering when it will stop?

I have stopped taking my Crohn's medication (methotrexate)i was suffering severe side effects. I'm still incredibly sick & wondering when it will stop?

Could be Crohn's: Some of the most common side effects can be similar to symptoms of crohn's. These include mouth sores, fever, diarrhea, blood in your stools, body aches and abdominal pain. You may want to check with your doctor and make sure this is not a flare up of your disease. ...Read more

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Rheummd says it's ok 2 change weekly methotrexate to a day that works 4 me. I take on tues. Now on dose #6 & dose is increased. Concern w/ side effects at work. Ok to switch to the sat or sun before?

No: Always best to follow the directions of a doctor who has seen and evaluated your problem. If having a concern call them and ask for clarification. ...Read more

Dr. Robert Lowe
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Rheumatrex (Definition)

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