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Doctor insights on: Effectiveness Tamoxifen Prevent Uterine Cancer

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Does taking tamoxifen for breast cancer treatment induce cancer of the womb?

Does taking tamoxifen for breast cancer treatment induce cancer of the womb?

Small risk: Tamoxifen is asociated with a small (less than 5%) risk of uterine cancers, women on tamoxifen require regular gynecologic checkups every 6-12 months and high-risk women may need ultrasound screeenings too. ...Read more

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Dr. Barry Rosen
4,342 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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Does tamoxifen cause uterine cancer?

Does tamoxifen cause uterine cancer?

It can.: The most definitive study that looked at uterine cancer rates associated with tamoxifen found that women had twice the risk of developing uterine cancer, at a rate of 1 per 500 women per year. This rate is far lower than the rate of breast cancer prevention; thus, the benefits far outweigh the risks. A better alternative after menopause is aromatase inhibitors, which do not increase this risk. ...Read more

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Does tamoxifen help prevent breast cancer?

Does tamoxifen help prevent breast cancer?

And new primaries: Tamoxifen blocks estrogen and Progesterone receptors which when stimulated can cause remnant cancer cells to be stimulated to grow back and also can cause normal cells to be overstimulated to develop into new hormonally sensitive cancer. Statistically it reduces the chance of recurrence by 30% and reduces the chance of a second primary by 50%. ...Read more

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Can taking tamoxifen for breast cancer treatment induce cancer of the uterus ?

Can taking tamoxifen for breast cancer treatment induce cancer of the uterus ?

Maybe: There is a slight increased risk of endometrial cancer of 1 in 500 chance reported. The benefits of tamoxifen in treatment of breast cancer is much higher than the risk of endometrial cancer. Ask your oncologist and ob-gyn how best to follow or watch for this potential risk. ...Read more

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Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Individual: Yes, estrogen alone does increase the risk of uterine cancer over time. And yes the whi showed that the combination of a certain synthetic estrogen and a certain synthetic progestin increased the risk of breast cancer. But most specialists do not use those older types of synthetic hormones and with newer medications the risks are lower and different. So a balance can be achieved. ...Read more

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Evista (raloxifene) estrogen receptor for uterine cancer?

Evista (raloxifene) estrogen receptor for uterine cancer?

Unclear Question?: These are somewhat unrelated questions which makes it difficult for me to address your question. Evista (raloxifene) is not used for treating cancer...It is sued for treatment/prevention of osteoporosis. Estrogen receptors are specialised protein receptors found in breast cancer.Uterine cancer has little bearing on either of the two references you have listed. ...Read more

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Does taking tamoxifen for breast cancer treatment induce development of cancer of the uterus?

Does taking tamoxifen for breast cancer treatment induce development of cancer of the uterus?

Yes: The chance is about 1% and treatment is hysterectomy. With such a low chance then tamoxifen is worth the risk. A gynecologist needs to keep track of the patient and any unusual bleeding evaluated. There are also other hormone alternatives with less risk. Check with your medical oncologist to see which drug is best for a particular patient. ...Read more

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Does natural progesterone prevent breast cancer?

Does natural progesterone prevent breast cancer?

No: There is no evidence Progesterone of any type prevents breast cancer, "natural" Progesterone or not. If a woman has menses that only occur a few times a year, six or four or fewer, however, Progesterone or progesterone-like compounds can very definitely prevent endometrial hyperplasia (which can lead to uterine cancer), and should be used regularly to oppose continuous estrogen stimulation. ...Read more

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Does uterine cancer increase the risk for colon cancer?

Does uterine cancer increase the risk for colon cancer?

Sometimes: There is a familial disorder known as lynch syndrome which increases both the risk of colon cancer and endometrial (uterine) cancer. About 5% of all colon cancers are caused by lynch syndrome. If a family has multiple cases of both colon and endometrial cancer or colon cancer under the age of 40, lynch syndrome should be considered. ...Read more

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Does taking tamoxifen for breast cancer treatment cause cancer of the uterus ?

Yes: Tamoxifen has been shown to increase the risk of uterine cancer, not unlike estrogen replacement therapy, with an incidence of ~1:500. However, this is almost-always caught at its earliest stage, with very high cure rates. If you compare the benefit of tamoxifen for either treating or preventing breast cancer compared to this risk, the benefit far outweighs the risk. ...Read more

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Does Mirena (levonorgestrel) prevents uterine cancer when using Estrogen patches?

Does Mirena (levonorgestrel) prevents uterine cancer when using Estrogen patches?

It is an option: The Mirena (levonorgestrel) can counteract or balance the estrogen from patches to prevent uterine cancer but the clinical data for this is limited. Everyone's situation is different but it is an option to discuss with your gyn. Here is a reference on pubmed.gov Climacteric. 2011 Dec;14(6):622-32. Copy and paste that and you will see the study. ...Read more

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Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Estrogen: Tamoxifen is given to individuals with specific breast cancers that are driven to grow by the presence of estrogen receptors. Tamoxifen interferes with the activity of estrogen in the breast, preventing cancer growth. The role of Progesterone receptors is unclear, though Progesterone receptors in breast cancer are generally associated with estrogen receptors, making tamoxifen an effective therapy. ...Read more

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Can an oopherectomy reduce breast cancer recurrence in premenopausal women?

Can an oopherectomy reduce breast cancer recurrence in premenopausal women?

YES for ER positive: Oopherectomy has been proven to reduce recurrence in estrogen-receptor positive pre-menopausal women. Prior to tamoxifen, it was a commonly used treatment for metastatic disease and is now known to reduce recurrence in high-risk premenopausal hormone-receptor positive breast cancer, even without the use of other endocrine therapies. ...Read more

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Is arimidex (anastrozole) when given as prevention of recurrence of breast cancer only used with estrogen receptive cancer?

Is arimidex (anastrozole) when given as prevention of recurrence of breast cancer only used with estrogen receptive cancer?

Yes*: Arimidex (anastrozole) belongs to a category of drugs called aromatase inhibitors. These are effective chemotherapeutic agents for people with either estrogen-sensitive or *progesterone-sensitive breast cancers. This is only effective after menopause; premenopausal women may use tamoxifen for a similar response rate. ...Read more

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Does arimidex (anastrozole) cause uterine cancer?

NO, it does not: You may be confusing Arimidex (anastrozole) with Tamoxifen(which can cause uterine cancer although it is a rare complication. Arimidex (anastrozole) has no such problem. ...Read more

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Will estrogen dominance always cause uterine cancer?

Estrogen/Uterine CA: Absolutely not. "high" estrogen levels are only one factor in the risk profile for uterine cancer, which also includes obesity, family history, and oral contraceptive history. Even if you possess one or more risk factors, that does not mean that a tumor is certain. Close monitoring and counselling by your gyn is the best course of action. ...Read more

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Does tamoxifen for breast cancer put me at risk for uterine cancer?

Does tamoxifen for breast cancer put me at risk for uterine cancer?

Yes. like ERT: The increase risk is similar to that of unopposed estrogen replacement therapy. It is important that all your doctors (esp your gyn in this case) are aware what medications you're taking and report any irregular vaginal bleeding/discharge or other pelvic symptoms. ...Read more

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How effective is taking low-dose tamoxifen for breast cancer risk reduction?

How effective is taking low-dose tamoxifen for breast cancer risk reduction?

Only One Dose: The use of tamoxifen for chemoprevention is associated with a 50% reduction in breast cancer in those at high risk. Like any drug, there are side-effects and potential complications. Therefore, this decision is best made in consultation with a cancer specialist. ...Read more

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Does the mirena (levonorgestrel) IUD increase a woman's overall breast cancer risk?

Does the mirena (levonorgestrel) IUD increase a woman's overall breast cancer risk?

No: There is really no evidence that the Mirena (levonorgestrel) iud increases cancer risk. In fact, there is some (albeit limited) evidence that it may decrease the risk of cancer. ...Read more

Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


Dr. John Geisler
228 doctors shared insights

Uterine Cancer (Definition)

Also known as cancer of the uterus, this is when cancer grows in the female organ in which the implantation of an embryo and carrying of a fetus take place. Cancer usually develops in the cells that form the uterine--a portion of which are shed ...Read more