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Doctor insights on: Effectiveness Tamoxifen Prevent Uterine Cancer

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Does tamoxifen cause uterine cancer?

Does tamoxifen cause uterine cancer?

Tamoxifen/Uterine CA: Studies have linked the use of tamoxifen to an increased risk - perhaps twice the natural rate - to endometrial cancer. While the drug blocks estrogen receptors in the breast to assist in limiting the spread and growth of breats cancer, it apparently can augment the estrogen effects on the uterus and contribute to uterine cancer development. ...Read more

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Dr. Barry Rosen
4,214 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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Can you get uterine cancer even after taking tamoxifen?

Can you get uterine cancer even after taking tamoxifen?

Yes: Tamoxifen is used in the treatment of breast cancer. One of its risks is a 1 percent chance of uterine cancer. You should be checked periodically by a gynecologist and if any vaginal bleeding when on tamoxifen may need a uterine biopsy and likely discontinuing the tamoxifen. Your oncologist should guide you. ...Read more

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Does tamoxifen for breast cancer put me at risk for uterine cancer?

Does tamoxifen for breast cancer put me at risk for uterine cancer?

Yes. like ERT: The increase risk is similar to that of unopposed estrogen replacement therapy. It is important that all your doctors (esp your gyn in this case) are aware what medications you're taking and report any irregular vaginal bleeding/discharge or other pelvic symptoms. ...Read more

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Can you prevent uterine cancer?

Can you prevent uterine cancer?

Not completely: You cannot completely prevent endometrial cancer. You can lower your risk by maintaining a healthy weight, exercising 30 minutes per day, taking birth control pills for one year or more, and avoiding estrogen-alone hormone replacement therapy after menopause. ...Read more

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Does Mirena (levonorgestrel) prevents uterine cancer when using Estrogen patches?

Does Mirena (levonorgestrel) prevents uterine cancer when using Estrogen patches?

It is an option: The Mirena (levonorgestrel) can counteract or balance the estrogen from patches to prevent uterine cancer but the clinical data for this is limited. Everyone's situation is different but it is an option to discuss with your gyn. Here is a reference on pubmed.gov Climacteric. 2011 Dec;14(6):622-32. Copy and paste that and you will see the study. ...Read more

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Use .5 mg estrace & 100 mg prometrium for 20 yrs. in post menopause. Does it offer protection in preventing uterine cancer?

Use .5 mg estrace & 100 mg prometrium for 20 yrs. in post menopause. Does it offer protection in preventing uterine cancer?

Not exactly: Progesterone use offset the effect of Estrogen in preventing endometrial hyperplasia. If someone is taking Estrogen and has a uterus then they also need to take Progesterone. Combined hormone therapy is not prescribed for the primary prevention of uterine cancer. ...Read more

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My wife dr installed mirena (levonorgestrel) to prevent uterine cancer. We do not believe in abortion but are ok with birth control. Does mirena (levonorgestrel) cause abortions?

My wife dr installed mirena (levonorgestrel) to prevent uterine cancer.  We do not believe in abortion but are ok with birth control.  Does mirena (levonorgestrel) cause abortions?

Probably: One mechanism of action for the Mirena (levonorgestrel) (and there are several) is the thinning of the endometrium. That makes the lining of the uterus less receptive to implantation of a fertilized egg. When a conception does occur, most of the time that fertilized egg will not implant and the pregnancy will not be established - this results in the Mirena (levonorgestrel) being an abortifacient at least part of the time. ...Read more

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How does uterine cancer affect your body?

How does uterine cancer affect your body?

Various way: Depending on the type of uterine cancer: it can go to another site (metastasis), which can affect the organs that it goes to. If you have a hysterectomy (removal of the uterus), along with lymph nodes in selected cases, you usually have a good outcome, depending on the tumor type and stage (where it has spread). Obviously, you cannot have any more children after this. ...Read more

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I have possible uterine cancer please help what do I do?

Depends on staging: If you've been diagnosed, the next question is to determine the stage. That would involve tests. The stage would determine the treatment. If you have "possible " uc, i don't know what that means -- have you had biopsy? Other tests? An abnormal pap smear? ...Read more

Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


Dr. Robert Marcus
214 doctors shared insights

Uterine Cancer (Definition)

Uterine cancer is cancer of the uterus, the female organ in which the implantation of an embryo and carrying of a fetus take place. Cancer usually develops in the cells that form the uterine--a portion of which are shed ...Read more