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Doctor insights on: Effect Zoloft Sertraline

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Dr. Heidi Fowler
1,094 Doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


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Will I get the same calming effect from Zoloft (sertraline) as I do from Valium but it will take a few weeks to work? GP doesn't want me on Valium long term.

Will I get the same calming effect from Zoloft (sertraline) as I do from Valium but it will take a few weeks to work? GP doesn't want me on Valium long term.

Can't predict: Sertraline is a 1st-generation SSRI like Prozac (fluoxetine). Diazepam is a benzodiazepine - chemically very different. BZDs cause psychological not physical dependence meaning that abruptly stopping (not recommended) won't kill you, you'll only wish you were dead. Temporarily, of course. Only way to know is to try it. Your brain doesn't run Windows 8.1; no predicting. ...Read more

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Can your triglycerites & cholesterol be effected by zoloft (sertraline)? My triglycerites are up 50 pts& my good cholesterol dropped 30 pts within a years time.

Can your triglycerites & cholesterol be effected by zoloft (sertraline)? My triglycerites are up 50 pts& my good cholesterol dropped 30 pts within a years time.

Metabolic Syndrome: Psychotropic medicines may effect weight and consequently cause or worsen metabolic conditions. More importantly mood and anxiety may predispose to metabolic disorders. Stresss increases cortisol that may increase lipids, blood sugar and cause weight gain. Age, family history and other condition should be factore in. A proper evaluation and investigations are essential. ...Read more

Dr. Alan Ali Dr. Ali
2 doctors agreed:
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Is tinnitus a side effect of zoloft (sertraline)?

Dr. Alan Ali Dr. Ali
2 doctors agreed:
Is tinnitus a side effect of zoloft (sertraline)?

Zoloft (sertraline): Very occasionally, dose related, or could be a symptom of anxiety. ...Read more

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Is forgetfulness a common side effect of Zoloft (sertraline)?

Not common: Confusion and other mood changes are more common with anti depressants like Zoloft (sertraline). Pl check the package insert for more details. ...Read more

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Is irregular pulse a side effect of Zoloft (sertraline) / setraline?

Is irregular pulse a side effect of Zoloft (sertraline) / setraline?

Very rare: While sertraline can rarely increase heart rate and has been associated with sinus tachycardia in cases of toxicity after overdose, there have only been a few cases of ventricular arrhythmias seen even is severe overdose. ...Read more

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Can derealization be a side effect of Zoloft (sertraline) or klonopin? I am on 75 mg of Zoloft (sertraline), 1mg of Klonopin. This is my 3rd week.

Can derealization be a side effect of Zoloft (sertraline) or klonopin? I am on 75 mg of Zoloft (sertraline), 1mg of Klonopin. This is my 3rd week.

Yes: Derealization CAN be subsequent to most any medication- best way to tell is to stop it - if it goes away wait a Few days and restart- of it occurs when you stop it not likely medication related- if it goes away and comes back when the med is restarted likely medication related ...Read more

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Is restless leg syndrome a side effect of zoloft (sertraline)?

Is restless leg syndrome a side effect of zoloft (sertraline)?

Occasionally yes: Genetics, alcohol and caffeine, changes in exercise patterns, certain meds, iron deficiency, kidney problems, nerve damage can all cause or worsen restless legs syndrome. Zoloft (sertraline) can sometimes. It looks like you're on Mellaril which can worsen RLS too. ...Read more

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I understand lack of sexual desire is a side effect of Zoloft (sertraline). However, I feel a lack of emotion (ie, happy, sad, . ..) is this also a side effect?

SSRIs: Zoloft (sertraline) is an antidepressant of the ssri class. Some people report feeling apathetic or their emotions are blunted while on these medicines. Let the doctor who prescribed zoloft (sertraline) know. A change in dose, switch to a different medicine or addition of another can help. ...Read more

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Is muscle weekness in the arms like having sore arma a side effect of zoloft (sertraline)?

Is muscle weekness in the arms like having sore arma a side effect of zoloft (sertraline)?

Could be: Very stiff and rigid muscles could be side effect of zoloft (sertraline) and you need to see your doctor. ...Read more

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Does Zoloft (sertraline) effect tramacets effectiveness?

Does Zoloft (sertraline) effect tramacets effectiveness?

Yes: Because Zoloft (sertraline) can affect tramadol conversion to the active metabolite (it decreases the conversion), you may notice decreased effectiveness of your tramadol/acetaminophen pills. Also, tramadol and Zoloft (sertraline) interact so the serotonin levels can be elevated. You need to watch to symptoms related to too much serotonin like headaches, muscle twitching, agitation, racing heart and diarrhea. ...Read more

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Does taking Zoloft (sertraline) effect. A mans sperm?

No: But ssri's can be associated with decreased libido, ejaculations issues / sexual dysfunction. ...Read more

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In dance class, I really felt like I might pass out. I was Seeing spots, hyperventilating, & had to sit. Is this a serious Zoloft (sertraline) effect? I am worried.

In dance class, I really felt like I might pass out. I was Seeing spots, hyperventilating, & had to sit. Is this a serious Zoloft (sertraline) effect? I am worried.

Anxiety: Sounds more like a panic attack. When you start to hyperventilate your body blows off carbon dioxide and that can cause your blood vessels to constrict. That causes the feeling of "passing out", visual spots and weakness. The mechanism is real. Continue your activities. Dance is excellent for exercise and relaxation. Stick with your meds. If symptoms are recurrent let your doctor know. ...Read more

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3 mrning dose of Zoloft (sertraline) cauzd insomnia. Now I take lexotanil to sleep. M healthy. Dun wana take any med. Bt cant sleep w/o lexo. How lng Zoloft (sertraline) effect end?

3 mrning dose of Zoloft (sertraline) cauzd insomnia. Now I take lexotanil to sleep. M healthy. Dun wana take any med. Bt cant sleep w/o lexo. How lng Zoloft (sertraline) effect end?

Sleep hygiene: It is best to wait at least 2-3 weeks to let the medication work before switching medications. Insomnia in the beginning is common. Pay attention to sleep hygiene. No alcohol, nicotine, caffeine within 4 hours of sleep, no naps, exercise, but not within an hour of sleep, do not use electronics like laptops or watch television before sleeping. The light affects wakefulness. Dark, quiet room. ...Read more

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I'm on zoloft (sertraline) 100mg doc want to add remeron at night because I steel feel litie deepest what dose can help with zoloft (sertraline), too much zoloft (sertraline) effect libido?

I'm on zoloft (sertraline) 100mg doc want to add remeron at night because I steel feel litie deepest what dose can help with zoloft (sertraline), too much zoloft (sertraline) effect libido?

Discuss w Psychiatry: Any change in the dose of your psychiatric medication needs to be discussed with your psychiatrist especially if you're combining it with another neuropsychiatric medication like Remeron (mirtazapine). Decreased libido can be a function of your depression as well and so it might not necessarily be your medication. Hope that helps and hope you feel better. ...Read more

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I was prescribed Zoloft (sertraline) and don't want it. Can I pour it down toilet?

Talk to your doctor: First, it is not a good idea to flush meds down the toilet due to filtration and sanitation concerns. It is best to have your physician's office, pharmacy or the police station dispose of them properly. As far as discontinuing zoloft (sertraline) on your own, I would strongly recommend that you speak with your doctor about your concerns with yhe med. ...Read more

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Will Zoloft (sertraline) help will obsessive harmful thought s that won't go away?

Will Zoloft (sertraline) help will obsessive harmful thought s that won't go away?

Maybe.: Sertraline is a reasonable drug to consider. It has more than a fair chance of working for you. ...Read more

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What should I do if I haven't felt any change after taking Zoloft (sertraline) for almost 4 weeks?

See your doctor: Like all antidepressants, it may take 4-6 weeks to feel the full benefit, but you should see at least some benefit within a couple of weeks zoloft can be dosed up to 150 mg so if you are on a lower dose, the dose can be increased. If you are already on150 mg then it is time to consider another antidepressant or adding abilify, (aripiprazole) wellbutrin, or Remeron to supplement the effects of the zoloft. ...Read more

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Does Zoloft (sertraline) make you gain weight? I've put on 30 lbs in two months and I can't loose it

Zoloft (sertraline) weight gain: Some people are very sensitive to mental medicines and would gain weight even with meds that are not kwown to make people gain weight. If you already have a weight issue and cannot lose weight easily, zoloft (sertraline) can also cause you some weight gain even thought it causes the least of that.
If you already have a healthy lifestyle, please make it better, if not then try to adopt a healthy one. ...Read more

Dr. Alan Ali Dr. Ali
1 doctor agreed:
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I feel like I've lost myself while being on Zoloft (sertraline) but I can't stop taking it what should I do?

Dr. Alan Ali Dr. Ali
1 doctor agreed:

Zoloft (sertraline): Not sure what dose u r taking & whether your symptoms started after increasing the dose, but I recommend reviewing those possibilities with your prescribing doctor to see if lowering the dose might be an option. ...Read more

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My normal 50 mg Zoloft (sertraline) doesn't help me anymore so I double dosed and I feel better. Is that okay?

My normal 50 mg Zoloft (sertraline) doesn't help me anymore so I double dosed and I feel better. Is that okay?

Yes, but....: Yes, but, first, you're lucky that you haven't experienced an adverse reaction to doubling your dose. We always advise patients only to change their medication with their physician's advice & consent, but, now that you've done so, please let your doctor know! Thanks! ...Read more

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I've been taking 1 50mg Zoloft (sertraline) a day, it hasn't been helping. Would it hurt me if I take 2 of the 50mg a day?

Don't know: What condition you are being treated for? Don't know how long you have been on this dose? It can take 4 to 6 weeks to get a full response of zoloft (sertraline) at your current dose. Please don't make any changes to your medications without discussing with your physician/ psychiatrist. ...Read more

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I'm on 50mg of Zoloft, (sertraline) once a day. I accidentally took two doses tonight (wasn't thinking). Should I worry about anything?

I'm on 50mg of Zoloft, (sertraline) once a day. I accidentally took two doses tonight (wasn't thinking). Should I worry about anything?

Zoloft (sertraline) Effects: Zoloft (sertraline) is a medication for treatment of Depression.

Zoloft (sertraline) 50mg/day is average maintenance dose
“I wasn't thinking” suggests that you feel overwhelmed with stress

Zoloft (sertraline) may cause
Nausea, insomnia. Anxiety, agitation, irritability, dizziness, headache

Treatment of Depression and anxiety is Therapy, Medication, Breathing Relaxation, Visual imagery, Yoga, and Meditation

See your Psychiatrist ...Read more

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I am coming off Zoloft, (sertraline) it worked for me last time, saved me. This time a year or two later it isn't working. Did I build up a tolerance?

I am coming off Zoloft, (sertraline) it worked for me last time, saved me. This time a year or two later it isn't working. Did I build up a tolerance?

Probably.: Some people have reported this phenomena that when they get off an antidepressant and they have to take it again for recurrence of depression, they notice that it takes a bigger dose to relieve their depression. I have read this in some literature and I have seen this with some of my patients. In fact, when the same antidepressant is restarted, you have to start with a higher dose. ...Read more

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My dr in oh requires frequent visits to refill Zoloft (sertraline) and doesn't change the rx. Is this acceptable practice? I have trouble refilling on time.

Common practice.: Many psychiatrists see patients monthly for refills. Sometimes more often if medication are being changed or if there are safety concerns. You might ask your doctor if she or he would consider lengthening out the time between office visits. Take care. ...Read more

Dr. Heidi Fowler
1,048 Doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more


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