Top
20
Doctor insights on: Duchenne Muscular Dystrophy Emedicine

Share
1

1
What causes duchenne muscular dystrophy?

What causes duchenne muscular dystrophy?

Genetic disorder: Duchenne's muscular dystrophy is an x linked genetic disorder causing abnormalities of the muscle fiber and eventual degeneration. ...Read more

Dr. Kathryn Mosher
141 doctors shared insights

Muscular Dystrophy (Definition)

Muscular dystrophy includes a number of disorders which are associated primarily with abnormalities of the architecture of the cells, often causing changes in size and function (weakness). These disorders are typically inherited, and recognized early in life, although there are of course exceptions to this. Prognosis is based on the type of MD and expression ...Read more


2

2
What causes duchenne muscular dystrophy?

Hereditary: It is inherited because of a defective gene on the x chromosome (female sex chromosome). It is referred to as a "sex-linked recessive" inheritance pattern. Girls get two x chromosomes, and the healthy one overrules the unhealthy gene, preventing girls from contracting the disorder. Boys get an x and a y. If the x has the defective gene, there is no corresponding gene on the y to overrule it. ...Read more

3

3
How are duchennes muscular dystrophy and myotonic muscular dystrophy different?

How are duchennes muscular dystrophy and myotonic muscular dystrophy different?

Amount of Dystrophin: The two conditions differ in their severity, age of onset, and rate of progression. Mutations in the dmd gene cause duchenne and becker forms of muscular dystrophy (dmd and bmd, respectively). Mutations that lead to an abnormal version of dystrophin that retains some function usually cause bmd, while mutations that prevent the production of any functional dystrophin causes dmd. ...Read more

4

4
What is duchenne muscular dystrophy?

X-Linked Reces. MD: Duchenne dystrophy is inherited as an x-linked recessive trait, carried in women. It affects about 1in 3500 male births with no geographic/ethnic variation. About 1/3 of the cases are caused by new mutations, the others are familial. Diagnosis is usually evident from clinical features. The abnormality is in the cytoskeletal protein dystrophin. It is unclear why the lack of dystrophin ->findings. ...Read more

5

5
What mutation type causes duchenne muscular dystrophy?

What mutation type causes duchenne muscular dystrophy?

Duchenne MD: Duchenne muscular dystrophy is caused by a defective gene for dystrophin (a protein in the muscles). It is inherited in an X-linked recessive fashion, but it often occurs in people from families without a known family history of the condition. Children with the condition should be followed with a multi-specialist team approach ...Read more

See 1 more doctor answer
6

6
What mutation type causes duchenne muscular dystrophy?

What mutation type causes duchenne muscular dystrophy?

DMD is caused by: mutation of Xp21.2-p21.1, a large gene that encodes dystrophin, a muscle protein. Deletions in specific areas of the gene are associated with cognitive impairment, verbal memory, auditory comprehension, increased risk of ADHD & Autistic Spectrum Disorder. Each son of a carrier mom has a 50% chance of having DMD. Carrier girls can have muscle weakness, including heart. See mda.org & a geneticist. ...Read more

See 2 more doctor answers
7

7
What are the differences between duchennes muscular dystrophy and myotonic muscular dystrophy?

What are the differences between duchennes muscular dystrophy and myotonic muscular dystrophy?

Both are inherited: neuromuscular disorders. DMD is caused by mutatation(s) on Chr. X. Onset of rapidly progressive muscle atrophy starts early in boys. Female carriers can have heart muscle disease. MD 1 is caused by mutant genes on Chr. 19; MD 2 by mutant genes on Chr. 3, Each child of a parent affected by either has a 50% chance of inheriting it, often with earlier & more severe symptoms than the parent's. ...Read more

8

8
What is progressive muscular dystrophy?

Muscle: It is a progressive disorder affecting the muscle causing weakness. ...Read more

See 1 more doctor answer
9

9
Are muscular dystrophy diseases inherited?

Yes, virtually all: Heredity varies from autosomal dominant to recessive and a few sex linked, but these are indeed genetically mediated muscle disorders. ...Read more

See 1 more doctor answer
10

10
Please help! what is the difference between duchennes muscular dystrophy and myotonic muscular dystrophy?

Good question.: The long answer reqires that you go to the internet so you can look at the typical facial features of myotonic dystrophy. The two conditions are not similar in presentaion. You should go with the long answer. ...Read more

11

11
How can one differentiate between duchenne muscular dystrophy and spinal muscular atrophy?

Diagnostics: Muscle biopsy or EMG will be able to differentiate. Presenting symptoms may lead one to be suspected more than the other as well. ...Read more

12

12
How does one acquire duchenne muscular dystrophy?

Bad genes: Duchenne type of muscular dystrophy is located on the x chromosome and is found in males. There are specific genetic tests that describe the disorder in detail. Women are carriers, and boys develop symptoms during early childhood. In utero testing is available. There is no cure, but early detection and possible use of steroids with appropriate therapy may modify the course. ...Read more

See 1 more doctor answer
13

13
What causes muscular dystrophy?

What causes muscular dystrophy?

Genetic disorder: There are different forms. Most common is duchenne that occurs in males but woman are carriers. Other forms are highly genetic such as fsh and myotonic dystrophy and the spectrum of sma. Genetic markers are available. ...Read more

See 1 more doctor answer
Dr. Jay Park Dr. Park
3 doctors agreed:
14

14
How come duchenne muscular dystrophy considered a genetic disorder?

Dr. Jay Park Dr. Park
3 doctors agreed:

Mutated gene in X : Duchenne muscular dystrophy is caused by an abnormal gene in x chromosome, and is inherited as an x-linked recessive trait. ...Read more

See 1 more doctor answer
15

15
What does "duchene muscular dystrophy" mean?

What does "duchene muscular dystrophy" mean?

Genetic muscle issue: Dmd is a genetic disorder in which there is a mutation in dystrophin, a structural protein found in muscle cell membrane. It causes progressive weakness that typically starts in the legs and pelvis, but eventually spreads throughout the body and also compromises breathing. There are symptomatic treatments, but no cure. ...Read more

See 1 more doctor answer
16

16
What sort of disorder is duchenne muscular dystrophy?

What sort of disorder is duchenne muscular dystrophy?

Muscle weakness: Dmd is a condition when muscles start to die prematurely. It starts in early childhood, leads to weakness of voluntary muscles such as those of hips, pelvic area, thighs and shoulders. Calves are often enlarged. Eventually it involves all muscles including that of heart and that control breathing. Life span is shortened to less than 30 years. It is a genetic condition primarily in boys. ...Read more

See 1 more doctor answer
17

17
Muscilar dystrophy related to dystrophin protein?

Muscilar dystrophy related to dystrophin protein?

Two types: The most common is duchennes with beckers a distant second. Both are related to muscle protein abnormal structure. ...Read more

18

18
What is muscular dystrophy?

Muscle disease: Muscular dystrophy is a worsening disorder that causes muscle weakness. The worst kind is duchenne's dystrophy, that affects only boys, leads to severe weakness, and wheelchair needs, breathing difficulties in the teens. Milder forms can present later or not cause as much disability. These are genetic (runs in families) disorders. ...Read more

See 1 more doctor answer
19

19
Does Ayurvedic medicine help in Duchenne muscular dystrophy?

Does Ayurvedic medicine help in Duchenne muscular dystrophy?

I don't know of any : scientific studies on this topic. Join Muscular Dystrophy Association India at mdindia.org. If any physicians have done research on the use of Ayurvedic medicine in DMD, you will find them or the results of their studies at MDIndia. ...Read more

20

20
Differentiate between duchenne and spinal muscular atrophy?

Differentiate between duchenne and spinal muscular atrophy?

Muscle vs motor neur: Duchenne muscular dystrophy is a disease of the muscles wherein the muscles degenerate and are replaced by fibrous and fatty tissue. Spinal muscular atrophy may look similar, but it is not a dystrophy. It is a disease of motor neurons. It is an inherited recessive disease. ...Read more

Dr. Hank Chambers
48 doctors shared insights

Duchenne Muscular Dystrophy (Definition)

A group of diseases that results in increasing weakening and breakdown ...Read more