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Doctor insights on: Drug Resistance

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Drug Resistance (Overview)

Drug resistance is the reduction in effectiveness, or the complete elimination of effectiveness, of a drug against the disease it is meant to treat. Drug resistance is an all to common occurrence with drugs meant to treat infections and certain malignancies.


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Is there HIV drug resistance to protease inhibitors?

Is there HIV drug resistance to protease inhibitors?

Yes: The HIV mutates frequently, and when a mutation produces resistance to protease inhibitors this will allow that form of the virus to multiply over other forms which are sensitive. That is one of the reasons for a drug combination which makes single mutational changes less likely to be favorable to the virus. ...Read more

Drug Resistance (Overview)

Drug resistance is the reduction in effectiveness, or the complete elimination of effectiveness, of a drug against the disease it is meant to treat. Drug resistance is an all to common occurrence with drugs meant to treat infections and certain malignancies.


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Can chronic insulin administration, by itself, cause insulin resistance?

Can chronic insulin administration, by itself, cause insulin resistance?

Insulin: Insulin resistance can occur but not when you are taking proper care of your diabetes. Are you checking your blood sugars regularly? Are you taking too much or too little insulin? Your doctor can teach you but you have to learn to take care of yourself. Many doctors offices have group treatment for this. ...Read more

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Are azt (zidovudine) type meds safe?

Are azt (zidovudine) type meds safe?

That depends: Azt (zidovudine) ishas a lot of side effects and toxicity, which is why it's less often used in the U.S. And other resource-rich countries these days. The more commonly used drugs in this class (the nucleoside analog reverse transcriptase inhibitors, or nrtis) are tenofovir, abacavir, lamivudine, and emtricitabine. These drugs are safer, more convenient, and more potent. ...Read more

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Which drug is most dangerous? Anabolic steroids, hallucinogens, or club (designer) drugs?

Which drug is most dangerous? Anabolic steroids, hallucinogens, or club (designer) drugs?

Tough 2 decide!: What an interesting question! Hard to say, steroids cause shrunken testicles, enlarged prostate, breast development, erectile dysfunction, reduced sperm count, severe acne, high blood pressure and strokes. Hallucinogens like LSD cause psychosis, flashbacks, schizophrenia, depression. Club drugs could be a lot of things, sudden death from arrhythmia is reported with several. All are dangerous! ...Read more

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How is insulin resistance/ whatever metformin is used to treat diagnosed? What tests will test insulin resistance?(what people are put on metformin 4)

How is insulin resistance/ whatever metformin is used to treat diagnosed? What tests will test insulin resistance?(what people are put on metformin 4)

Diabetes type II: by definition has insulin resistance. Unless there is a compelling reason to test for insulin levels, having a clinical and demographic picture consistent with diabetes II is all that is needed. metformin helps that one; it doesnt work in type I. ...Read more

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Is doxycycline a resistant drug?

Is doxycycline a resistant drug?

???: I don't know what you mean by a "resistant drug." bacteria can be resistant, not antibiotics. ...Read more

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Metformin - side effects? Using this to counteract insulin resistance. Any comments on side effects etc?

See below most commo: Abnormal stools Changes in taste Muscle pain Difficulty breathing Lightheadedness or dizziness Nail problems Flu-like symptoms such as muscle pain, fever, chills, and weakness Feelings of a rapidly or forcefully beating heart (heart palpitations). Flushing (a skin reddening, commonly on the face) Increased sweating Increased thirst ...Read more

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Can statin drugs increase creatinine level?

Can statin drugs increase creatinine level?

Yes: While very uncommon, all of the statin drugs have been known to cause muscle injury. The release from injured muscle of a substance called myoglobin can plug up the kidneys and cause the creatinine to rise. However, under those circumstances there is usually significant muscle pain or weakness and often the urine has a reddish appearance. Also a muscle enzyme (CPK) will be strikingly elevated. ...Read more

Dr. James Fox Dr. Fox
6 doctors agreed:
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What does ‘ drug resistance’ mean?

Dr. James Fox Dr. Fox
6 doctors agreed:
What does ‘ drug resistance’ mean?

Doesn't work: Essentially, it means that the drug is ineffective for the intended treatment. If you're talking about "drug resistant" bacteria, it means that the antibiotic chosen will not eliminate the bacteria. If you are talking about depression, "drug resistance" or "treatment resistance" means that that drug does not effectively treat your depression. ...Read more

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Which antipsychotics are low risk for weight gain and drug induced cystic acne?

Which antipsychotics are low risk for weight gain and drug induced cystic acne?

Antipsychotics: You MUST have your Primary doctor refer you as soon as possible to a Psychologist. I think you will be pleasantly surprised when you start seeing the Psychologist! Please let me know how things go ...Read more

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I'm taking the drug januvia (sitagliptin) for type 2 diabetes is this a safe drug to take?

I'm taking the drug januvia (sitagliptin) for type 2 diabetes is this a safe drug to take?

Very safe: Januvia (sitagliptin) has very few side effects. Unlike some other diabetes drugs (glipizide, Insulin etc) it does not cause hypoglycemia attacks, nor increase appetite and weight. There have been rare reports of pancreatitis but these have not been confirmed in clinical trials, and may be simply due to the fact that patients with diabetes are more likely to get pancreatitis irrespective of treatment. ...Read more

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How common is drug resistant tb?

DRUG RESISTANT TB: It is very common, thats why we have to use multiple antibiotics. ...Read more

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Can increased prolactin cause insulin resistance?

Can increased prolactin cause insulin resistance?

Probably not: I am not aware of high prolactin causing Insulin resistance. However, some people with Insulin resistance and polycystic ovarian syndrome can have high prolactin levels. ...Read more

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Is intermittent fasting effective for reducing insulin resistance?

No because: Your body is smarter than you and slows down it's metabolism when you fast. You need to find a restricted diet and increased exercise program you can follow for the rest of your life, because things aren't going to go away by themselves, only worsen over time unless you do something to make them better. ...Read more

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Levodopa is ineffective in drug induced parkinsonism, why?

Levodopa is ineffective in drug induced parkinsonism, why?

A few reasons: First there are two different drug induced parkinsons. Acutely (in which case just stop the drug), and chronically (tardive dyskinesia...TD). TD is generally in those with psychosis. Levodopa can make that worse. Bad. AND, Levodopa has been associated with more rapid progression in regular Parkinsons, so we dont like to use it in anyone if we can avoid it. ...Read more

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Changing insulin from humalog (insulin lispro) to novolog - any effect?

Changing insulin from humalog (insulin lispro) to novolog - any effect?

Congratulations: Great move. Well, NovoLog is quicker acting but also quicker getting out of your system. So make sure you eat as soon as you inject. As with any insulin, proper close titration is necessary to avoid hypoglycemia and wild fluctuations in your sugar levels. Overall, best short acting Insulin on the market at present, and the most physiologic. ...Read more

Tolerance (Definition)

When one takes a drug, such as heroin or alcohol, repeatedly, 'tolerance' develops because more of the drug is needed to give the same effect on the body/brain; e.g. Liver enzymes r stimulated to metabolize the drug faster and faster. There may be a strong genetic predisposition to addiction, some studies suggesting that 1 of 10 people will become dependent on alcohol or some ...Read more