Doctor insights on:
Drug Half Life
How long is Extended Release 2mg Xanax (alprazolam) half life, compared to 2mg Klonopin half life?
Xanax (alprazolam) XR vs Klonopin: The half-life for Xanax (alprazolam) XR is short 10.7–15.8 hours and the longer-term efficacy of Xanax (alprazolam) XR has not been systematically evaluated. Klonopin has an unusually long elimination half-life of 18–50 hours, it considered the longest-acting benzodiazepine. ...Read moreSee 2 more doctor answers
1mg dose of klonopin (clonazepam) lasts for about 8 hours.Half life 18-60 hours.The half life seems meaningless if it only therapeutically works 8 hrs.Explain?
Therapeutic: Of course these are just standards for a general population. But, therapeutic levels represents a blood concentration that is high enough to see the effect of the medication still working. Blood levels of the chemical/drug/medicine are detectable but not at a level to provide with the well known effect of the medication. ...Read more
Metropolol half life is 3-7 hours. How can Metropolol Succinate stay in the bloodstream for 24 hours if half life is only 3-7 hours?
They are different: Metoprolol does have a 3-7 half-life, but that’s metoprolol tartrate, which is immediately absorbed into the bloodstream. The succinate version of metoprolol, however, also comes in a tablet (“extended-release”) that gives a person small amounts of medication over 24 hours. So the half-life - the rate the person eliminates the drug - is not different, but the rate the tablet releases it is. ...Read moreSee 1 more doctor answer
Does 50 mg of modafinil(half of prescribed dose) is effective for drowsiness?.Drug tolerance chance?.Elimination half life?I will start tomorrow.
Dose may be low: The dose maybe somewhat low. Comes in 50s, 150s and 250 in the us. The half-life is 12 to 15 hours. I do not generally encounter tolerance developing to this medication. The only exception to that rule might be someone with idiopathic central nervous system hypersomnolence. Best wishes and i hope that this does a good job working on your hypersomnolence. Take care. ...Read more
Longer.: I use Tranzene.Get a more detailed answer ›
Depends.: I am assuming you are talking about the half life of a drug. A drug with a 25 hours half life means that after 25 hours, the blood concentration of the drug will be halved. So at hour zero it's 100%. At 25 hours , the concentration is 50%. At 50 hours, it's 25%. At 75 hours, it's 12.5% etc. Please note that using half lives is an oversimplification and doesn't always correlate with drug effect. ...Read moreSee 2 more doctor answers
Less than a week: Typically this drug is not detectable by the urine drug screen after 4 to 5 days. It depends on the condition of your liver and if other drugs are present and competing for metabolism. It also depends on the sensitivity and specificity of the test itself. Hope this helps! ...Read moreSee 2 more doctor answers
Latuda (lurasidone) Half Life: The activity of Latuda (lurasidone) is primarily due to the parent drug. The pharmacokinetics of Latuda (lurasidone) is dose-proportional within a total daily dose range of 20 mg to 160 mg. Steady-state concentrations of Latuda (lurasidone) are reached within 7 days of starting Latuda (lurasidone). Following administration of 40 mg of Latuda (lurasidone), the mean (%CV) elimination half-life was 18 (7) hours. Absorption and Distribution: Latuda (lurasidone) is absorbed and reaches peak serum concentrations in approximately 1-3 hours. It is estimated that 9-19% of an administered dose is absorbed. Following administration of 40 mg of Latuda (lurasidone), the mean (%CV) apparent volume of distribution was 6173 (17.2) L. Latuda (lurasidone) is highly bound (~99%) to serum proteins. In a food effect study, Latuda (lurasidone) mean Cmax and AUC were about 3-times and 2-times, respectively, when administered with food compared to the levels observed under fasting conditions. Latuda (lurasidone) exposure was not affected as meal size was increased from 350 to 1000 calories and was independent of meal fat content ...Read more
If klonopin (clonazepam) has such a long half life -- 18-50 hours according to wikipedia -- why do its anxiolytic effects only last 4-6 hours for me?
Clonazepam duration: Here is one possible reason:clonazepam plasma levels are very unreliable amongst patients. Plasma levels of Clonazepam can vary as much as tenfold between different patients.En.Wikipedia.Org/wiki/clonazepam also you are not alone: www.Socialanxietysupport.Com/forum/f30/klonopin-halflife... These half life figures make no sense to me, k helps me for about 4 hours max. ...Read more