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Doctor insights on: Doxylamine Side Effects

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Hydroxyzine and Benadryl (diphenhydramine) both give me similar horrible side effects, but doxylamine does not, is there a reason for this?

Hydroxyzine and Benadryl (diphenhydramine) both give me similar horrible side effects, but doxylamine does not, is there a reason for this?

Yes: Both Hydroxyzine and Benadryl (diphenhydramine) are highly sedating for people, while doxylamine has less sedating effect. The newer antihistamines have very low or no sedating effects. ...Read more

Dr. Brad Goldenberg
74 doctors shared insights

Doxylamine (Definition)

Doxylamine is an antihistamine which is ...Read more


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Hi, how likely is it to develop a tolerance to the sedating effects of doxylamine succinate when taken daily for a longer period of time?

Hi, how likely is it to develop a tolerance to the sedating effects of doxylamine succinate when taken daily for a longer period of time?

Tolerance: to doxylamine can develop overtime, needing more to have the same desired effect, interrupted use can delay that, however, it is hard to predcit which individual would develop tolerance and after how long, as metabolism differs, depending on multitude of factors in every person ...Read more

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Sis overdosed in trazodone, doxylamine, lorazepam, anti-emetics over 24h ago. Sleeps a lot, feels dizzy. Will the effects increase or wear down? Help

Sis overdosed in trazodone, doxylamine, lorazepam,  anti-emetics over 24h ago. Sleeps a lot, feels dizzy. Will the effects increase or wear down? Help

Bad combo: These medications are all sedating and have a potential to interact depending on the dosage taken. Lorazepam ingestion can be reversed with a medication called flumazenil (clonazepam). It sounds like you're quite concerned about your sister ... Going to the ER and making sure that she receives the proper medical and (more importantly) psychiatric care is definitely your best bet. Hope that helps! ...Read more

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How can I treat doxylamine overdose?

How can I treat doxylamine overdose?

Get Help: A true overdose is a medical emergency requiring immediate attention. After the emergency is over, then we look to find out how it happened. Is this part of a substance abuse problem? Are there memory problems such that the person doesn't recall how many pills they took? Is this a suicide attempt? All of these are important questions that will lead you to the next step. ...Read more

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Is 50mg of doxylamine succinate safe?

Is 50mg of doxylamine succinate safe?

Yes: The FDA approved, label dosages for insomnia are from 25-50 mg nightly. We use this medication off-label routinely to treat morning sickness in pregnant women at higher doses than this. Overall it is a very safe and well tolerated medication. It can cause urinary retention in older people with prostate or bladder issues though. ...Read more

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Is doxylamine succinate habit-forming?

Is doxylamine succinate habit-forming?

Unisom: is not considered to be addictive in that there are no withdrawal side effects. Its use over a long period of time is not recommended as it has anticholinergic side effects that can interfere with memory, attention and ability to deal with outside stimuli. Do not take it with other sedatives or antihistamines like Zyrtec (cetirizine). ...Read more

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What will taking ten doxylamine succinate do?

What will taking ten doxylamine succinate do?

Not a good idea: 1 800 222 1222 is the number for poison control if this occurs and...... Have somebody take you to the emergency room to get your stomach pumped. Anticholinergic side effects can include, racing hert, pounding chest, hallucinations, seizures, dry mouth, thickened secretions. ...Read more