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Doctor insights on: Doxylamine Medication

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Is it possible for one to become addicted to sedating medications? Products with ingredients such as diphenydramine, doxylamine, chlorphenirmine, etc?

Is it possible for one to become addicted to sedating medications? Products with ingredients such as diphenydramine, doxylamine, chlorphenirmine, etc?

Yes for example: Diphenhydramine can have a paradoxical effect, over a long period of use / that is it can produce restlessness & agitation and anxiousness instead of drowsiness or sleep. Remember addiction/dependency starts as habitual use and abuse before it becomes a chemical dependency! ...Read more

Dr. Linda Callaghan
80 Doctors shared insights

Doxylamine (Definition)

Doxylamine is an antihistamine which is ...Read more


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Found 2 medications that take away my mystery chronic body pain the day after taking them. Doxylamine succinate And diazepam, what could pain cause be?

Found 2 medications that take away my mystery chronic body pain the day after taking them. Doxylamine succinate And diazepam, what could pain cause be?

Take a deep breath: Some good news and some that can be difficult. The good news: You've found things that work, there's nothing seriously wrong or likely to worsen. The hard stuff is that you're suffering from tension/anxiety. The antihistamine helps you get better rest which can help neck and eye pain but can make you groggy. The Valium calms you but is best for specific stressful events. Find CBT therapy for help. ...Read more

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Is diphenhydramine the same drug as doxylamine?

Is diphenhydramine the same drug as doxylamine?

No: Both are antihistamines but are different chemicals. ...Read more

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If I become resistant to effects of diphenhydramine drowsiness, can I switch to doxylamine, or am I resistant to that too since they're similar drugs?

If I become resistant to effects of diphenhydramine drowsiness, can I switch to doxylamine, or am I resistant to that too since they're similar drugs?

You can switch.: They are different drugs so I would suspect you will be sedated by the doxylamine in spite of prior Benadryl (diphenhydramine) use. Best wishes. ...Read more

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I am allergic to ondansetron, other anti nausea drugs don't help, would doxylamine and B6 help with nausea with migraine?

I am allergic to ondansetron, other anti nausea drugs don't help, would doxylamine and B6 help with nausea with migraine?

More options:: A simple way to v nausea is w ginger. You can drink slightly flattened ginger ale or nibble on crystallized ginger. Or pour boiling water over freshly sliced organic ginger ; steep at least 5 min in a covered pot. Sip. Aromatherapy: sweet orange (citrus sinensis), peitigrain (citrus reticulata), mandarin (citrus reticulata) are different citrus scents that can v nausea. Need to abort migraine. ...Read more

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Are there any non-sedative antihistamines that work like doxylamine? It is the only drug that helps my allergies. Claritin/lortadine do not help.

Are there any non-sedative antihistamines that work like doxylamine? It is the only drug that helps my allergies. Claritin/lortadine do not help.

Yes: Doxylamine has anti-allergy power superior to almost every other antihistamine on the market, with the exception of Diphenhydramine (benadryl), which is also sedating.

Other than claritin/loratadine, there are other non-sedating antihistamines such as allergra (fexofenadine). Zyrtec (cetirizine) (ceterizine) is generally non-sedating although ~5% feel sedated with it. ...Read more

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Could doxylamine succinate (Equate Sleep Aid) create a false positive on a hair drug screen?

Could doxylamine succinate (Equate Sleep Aid) create a false positive on a hair drug screen?

No: There are virtually no false positives in hair testing, since it is done with GC/MS or other comparable sophisticated confirmatory tests. Doxylamine can cause false positives tests for Methadone and PCP on screening tests, but NOT on the confirmatory tests. ...Read more

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What would happen if I took 250mg of doxylamine succinate?

What would happen if I took 250mg of doxylamine succinate?

Not a good idea: Recommended dose of this antihistamine 25 mg.
"Doxylamine, a first-generation antihistamine, is identified in the Beers Criteria as a potentially inappropriate medication to be avoided in patients 65 years and older (independent of diagnosis or condition) due to its potent anticholinergic properties resulting in increased risk of confusion, dry mouth, constipation, and anticholinergic effects" ...Read more

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How can I treat doxylamine overdose?

How can I treat doxylamine overdose?

Get Help: A true overdose is a medical emergency requiring immediate attention. After the emergency is over, then we look to find out how it happened. Is this part of a substance abuse problem? Are there memory problems such that the person doesn't recall how many pills they took? Is this a suicide attempt? All of these are important questions that will lead you to the next step. ...Read more

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Is 50mg of doxylamine succinate safe?

Is 50mg of doxylamine succinate safe?

Yes: The FDA approved, label dosages for insomnia are from 25-50 mg nightly. We use this medication off-label routinely to treat morning sickness in pregnant women at higher doses than this. Overall it is a very safe and well tolerated medication. It can cause urinary retention in older people with prostate or bladder issues though. ...Read more

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Is doxylamine succinate habit-forming?

Is doxylamine succinate habit-forming?

Unisom: Is not considered to be addictive in that there are no withdrawal side effects. Its use over a long period of time is not recommended as it has anticholinergic side effects that can interfere with memory, attention and ability to deal with outside stimuli. Do not take it with other sedatives or antihistamines like Zyrtec (cetirizine). ...Read more

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What will taking ten doxylamine succinate do?

What will taking ten doxylamine succinate do?

Not a good idea: 1 800 222 1222 is the number for poison control if this occurs and......
Have somebody take you to the emergency room to get your stomach pumped. Anticholinergic side effects can include, racing hert, pounding chest, hallucinations, seizures, dry mouth, thickened secretions. ...Read more

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What is the definition or description of: Doxylamine overdose?

Dosylamine: Doxylamine is an antihistamine that can be used short-term to help sleep. The usual dose is 25 mg orally once a day before bed. The median lethal dose (LD50) is estimated to be 50–500 mg/kg. An overdose is accidental or intentional ingestion or application of an excessive dose of a medication. Medications overdoses may be dangerous and may lead to death in some situations. ...Read more

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Is it ok to take 25mg of doxylamine succinate daily before going to bed?

Sure: Depending on other medications/treatments and your prior medical history -- should be fine. Hope that helps! ...Read more

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Can you tell me what to do if I took 250 mg of doxylamine succinate will I be alright?

Can you tell me what to do if I took 250 mg of doxylamine succinate will I be alright?

Good luck: If you are fine by the time you are reading this answer, then nothing happened. Doxylamine is in an antihistamine: it can make you tired, dry mouse, dizzy, etc. The effects should wear off in a few hours, if you are healthy.
If you do this medication for fun – do not do it. Find some other ways to have fun. I treat a lot of patients who got hooked on medications quickly ...Read more

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Is it ok to use doxylamine succinate at 25-50 mg for more than 2 weeks. Also how long of a break is needed between 2 wks of using it? Thanks

Is it ok to use doxylamine succinate at 25-50 mg for more than 2 weeks. Also how long of a break is needed between 2 wks of using it? Thanks

Yes it is ok: Doxylamine succinate is a first generation antihistamine and is used for allergy. As compared to the second generation antihistamines like loratadine (Claritin)it will cause drowsiness.But if you can tolerate and have no side effects you can take it in dose of 25mgm longer than 2weeks. But I advice my patients to switch to second generation antihistamines like Claritin, Allegra, Zyrtec or Xyzal. ...Read more

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Is 50 mg of doxylamine succinate safe to take for sleep?

Is 50 mg of doxylamine succinate safe to take for sleep?

Doxylamine: Doxylamine is not a sleeping medication.
It is an Antihistamine which makes you drowsy
Conflicts with parents, relationships with turmoil and separations, peer pressure, work and finances can cause Anxiety and sleep problem
Trust your body to have sleep as it has done for 21 years
Exercise in evening
Use Breathing Relaxation, Visual Imagery, Tai Chi, Yoga, and Meditation, Music
See a Psychiatrist ...Read more

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How much Doxylamine Succinate mg does it take to kill you?

How much Doxylamine Succinate mg does it take to kill you?

Please seek help: If you or someone you know overdosed it is contemplating overdosing please seek help immediately. Symptoms of overdose are fever, confusion, dry mouth, racing heart, and delirium. ...Read more

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Do you think I should take doxylamine or ambien (zolpidem)?

Do you think I should take doxylamine or ambien (zolpidem)?

For what?: Doxylamine (unisom) is an anti-histamine which causes sedation. Ambien (zolpidem) is a sedative-hypnotic. I'd guess the question i'd ask is why do you need either? Perhaps get a referral to a sleep specialist so he/she can get a good history and perhaps find a solution as to why you feel you need any medication at all to help with sleep. Perhaps neither med is the right solution for you. ...Read more

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Is it safe to take 1/2 a pill of doxylamine succinate every night?

Is it safe to take 1/2 a pill of doxylamine succinate every night?

Doxylamine: Doxylamine succinate trouble of the active ingredient in Unisom, is a non-habit-forming antihistamine that promotes sleep. As long as you tolerate it well, it should not hurt you to take a half a tab of that each evening, but it would be better if you could figure out a way not to take it every night. Good luck. ...Read more

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Is 50mg safe to take off doxylamine succinate? Can it cause headaches?

Is 50mg safe to take off doxylamine succinate? Can it cause headaches?

50 mg is safe: Doxylamine is an antihistamine that is prescribed for sedation. The usual doseage is 6 to 50 mg at night. Doxylamine is not addictive. Do not use it with other antihistamines or sedatives or alcohol! dry mouth or dizziness is possible; headache would be uncommon. ...Read more

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Is it safe to take doxylamine for insomina on a regular basis for months?

Is it safe to take doxylamine for insomina on a regular basis for months?

Do you need to?: That's a better question, and the follow up is why do you need it? The drug itself is similar to Benadryl (diphenhydramine) with similar side effects. It's never wise to take sleeping aids for long term without looking for an underlying cause for the sleep problem. I would suggest yo speak to your doctor about your sleep problems and see if you can find out what's causing you to not sleep well in the first place. ...Read more

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Will taking doxylamine at night last long enough to help with my midday nausea?

Will taking doxylamine at night last long enough to help with my midday nausea?

Try it and see!: One half tablet of doxylamine can be taken along with vitamin B6 (pyridoxine) three times daily for nausea of pregnancy. As a side effect can be sleepiness, an alternative is to take a full tablet at bedtime, and just use the B6 during the day. Try both ways and see what works for you. ...Read more

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How often can I take doxylamine? If I took one and haven't fallen asleep after 8 hours, can I take another?

How often can I take doxylamine? If I took one and haven't fallen asleep after 8 hours, can I take another?

No: Once you take Doxylamine, you should be able to fall asleep within 30 min. But, once you take the medicine, don't start or get involved in any physical activity. You should be in a relaxed physically and mentally and be ready to go to bed. You might also try some relaxation techniques to help you sleep along with the medication. Don't take the medication too late either. ...Read more